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The Protein Binding of SZ1676, SZ1677 and Rocuronium and Their Inhibitory Effect on Human Cholinesterases

  • Ijaz A. Chaudhry
  • Francis F. Foldes
  • Hideo Nagashima
Conference paper

Abstract

SZ1676,1-[3α,17β-bis(acetyloxy)-2β-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-5α-androstan-16β-yl]-1-(2-propenyl)pyrrolidinium.Br, and its 3-OH derivative, SZ1677, are steroid type, nondepolarizing muscle relaxants(MR) under investigation. Rocuronium,1 another steroid type nondepolarizing MR, has been recently introduced into clinical practice. The present study has been undertaken as a part the characterization of the pharmacological profile of these MR.

Keywords

Pharmacological Profile Inhibitory Potency Albert Einstein College East 210th Neuromuscular Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Foldes FF, Nagashima H, Nguyen HO et al. Anesthesiology 75:191–96, 1991.PubMedCrossRefGoogle Scholar
  2. 2.
    Foldes FF, Deery A. In: Handbook of Experimental Pharmacology (Kharkevich DA, Ed), Springer-Verlag, Berlin, 1986. pp 225–31.Google Scholar
  3. 3.
    Thut PD, Lure TH, Cordes CT, Foldes FF. Anesth Analg 78:S438, 1994.Google Scholar
  4. 4.
    Foldes FF, Tuba Z, Nagashima H et al. Anesth Analg 78:S117, 1994.Google Scholar

Copyright information

© Springer Japan 1995

Authors and Affiliations

  • Ijaz A. Chaudhry
    • 1
  • Francis F. Foldes
    • 1
  • Hideo Nagashima
    • 1
  1. 1.Department of AnesthesiologyMontefiore Medical Center/Albert Einstein College of MedicineBronxUSA

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