The Protein Binding of SZ1676, SZ1677 and Rocuronium and Their Inhibitory Effect on Human Cholinesterases
SZ1676,1-[3α,17β-bis(acetyloxy)-2β-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-5α-androstan-16β-yl]-1-(2-propenyl)pyrrolidinium.Br, and its 3-OH derivative, SZ1677, are steroid type, nondepolarizing muscle relaxants(MR) under investigation. Rocuronium,1 another steroid type nondepolarizing MR, has been recently introduced into clinical practice. The present study has been undertaken as a part the characterization of the pharmacological profile of these MR.
KeywordsPharmacological Profile Inhibitory Potency Albert Einstein College East 210th Neuromuscular Effect
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