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The Protein Binding of SZ1676, SZ1677 and Rocuronium and Their Inhibitory Effect on Human Cholinesterases

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Muscle Relaxants

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Abstract

SZ1676,1-[3α,17β-bis(acetyloxy)-2β-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-5α-androstan-16β-yl]-1-(2-propenyl)pyrrolidinium.Br, and its 3-OH derivative, SZ1677, are steroid type, nondepolarizing muscle relaxants(MR) under investigation. Rocuronium,1 another steroid type nondepolarizing MR, has been recently introduced into clinical practice. The present study has been undertaken as a part the characterization of the pharmacological profile of these MR.

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References

  1. Foldes FF, Nagashima H, Nguyen HO et al. Anesthesiology 75:191–96, 1991.

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Author information

Authors and Affiliations

  1. Department of Anesthesiology, Montefiore Medical Center/Albert Einstein College of Medicine, 111 East 210th St., Bronx, NY, 10467, USA

    Ijaz A. Chaudhry, Francis F. Foldes & Hideo Nagashima

Authors
  1. Ijaz A. Chaudhry
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  2. Francis F. Foldes
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  3. Hideo Nagashima
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Editor information

Editors and Affiliations

  1. Department of Anesthesiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160, Japan

    Kazuaki Fukushima M.D., Ph.D (Professor and Chairman) & Ryoichi Ochiai M.D., Ph.D (Professor and Chairman) & 

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© 1995 Springer Japan

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Chaudhry, I.A., Foldes, F.F., Nagashima, H. (1995). The Protein Binding of SZ1676, SZ1677 and Rocuronium and Their Inhibitory Effect on Human Cholinesterases. In: Fukushima, K., Ochiai, R. (eds) Muscle Relaxants. Springer, Tokyo. https://doi.org/10.1007/978-4-431-66896-1_81

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  • DOI: https://doi.org/10.1007/978-4-431-66896-1_81

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-66898-5

  • Online ISBN: 978-4-431-66896-1

  • eBook Packages: Springer Book Archive

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