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Future Goals of the Benzylisoquinolinium Ester Program

  • John J. Savarese
  • Cynthia A. Lien
  • Matthew R. Belmont
  • R. Brandt Maehr
  • William B. Wastila
Conference paper

Abstract

This program originally sought to produce three nondepolarizing relaxants: short-, intermediate- and long-acting drugs which at the time (1975)1 were unknown. The proposed compounds are described in Fig 1. Now, twenty years later, much progress has been made, yet there is still room for additional improvement.

Keywords

Histamine Release Clinical Duration Nondepolarizing Muscle Relaxant Mivacurium Chloride Hofmann Elimination 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Savarese JJ, Kitz RJ: Does clinical anesthesia need new neuromuscular blocking agents? (Editorial). Anesthesiology 42:236–239, 1975.PubMedCrossRefGoogle Scholar
  2. 2.
    Basta SJ, Savarese JJ, A1i HH, et a1: Clinical pharmacology of doxacurium chloride (BW A938U): a new long-acting nondepolarizing muscle relaxant. Anesthesiology 69: 478–485, 1988.PubMedCrossRefGoogle Scholar
  3. 3.
    Belmont, MR, Lien CA, Quessy S, Abou-Donia MM, Abalos A, Eppich L, Savarese JJ: The clinical neuromuscular pharmacology of 51W89 in patients receiving nitrous oxide-opioid-barbiturate anesthesia. Anesthesiology (May 1995) Accepted for publication.Google Scholar
  4. 4.
    Lien, CA, Belmont MR, Abalos A, Eppich L, Quessy S, Abou-Donia MM, Savarese JJ: The cardiovascular effects and histamine releasing properties of 51W89 in patients receiving nitrous oxide-opioid-barbiturate anesthesia. Anesthesiology (May 1995) accepted for publication.Google Scholar
  5. 5.
    Lien CA, Schmith VD, Belmont MR, Abalos A, Kisor DF, Savarese JJ: Pharmacokinetics of 51W89 in patients receiving nitrous oxide-opioid-barbiturate anesthesia. Anesthesiology (1995), submitted.Google Scholar
  6. 6.
    Savarese JJ, Ali HH, Basta SJ et al: The clinical pharmacology of mivacurium chloride (BW B10904): a short-acting nondepolarizing ester neuromuscular blocking drug. Anesthesiology 68:723–732, 1988.PubMedCrossRefGoogle Scholar
  7. 7.
    Ali HH, Brull SJ, Witkowski T, Kipman A, Silverman DG, Goudsouzian NG, Bartkowski R, Weakly N: Efficacy and safety of divided-dose administration of mivacurium for rapid tracheal intubation. Anesthesiology 79:A934, 1933.Google Scholar
  8. 8.
    Bownes PB, Hartman GS, Chiscolm D, Savarese JJ: Antagonism of mivacurium blockade by purified human butyryl cholinesterase in cats. Anesthesiology 77:A909, 1992.CrossRefGoogle Scholar

Copyright information

© Springer Japan 1995

Authors and Affiliations

  • John J. Savarese
    • 1
  • Cynthia A. Lien
    • 1
  • Matthew R. Belmont
    • 1
  • R. Brandt Maehr
    • 2
  • William B. Wastila
    • 2
  1. 1.The New York Hospital-Cornell Medical CenterNew YorkUSA
  2. 2.Division of PharmacologyBurroughs Wellcome Co.Research Triangle ParkUSA

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