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Presynaptic Neuromuscular Blockade

  • Conference paper
Muscle Relaxants

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Summary

Problems with presynaptic effects of neuromuscular blocking agents including their mechanisms and their clinical role were discussed from an electrophysiological viewpoint. Since intracellular electrodes were induced into the field of investigation of neuromuscular transmission, mechanisms of neuromuscular blockig agents had been defined extensively, however, progress of the studies produced also new unidentified problems in which prejunctional inhibitory effect of non-depolarizing relaxants was included. In conclusion our findings and opinions from many reports, it is possible to state that non-depolarizing relaxants have an inhibitory effect on the transmitter releasing mechanisms in motor nerve terminals, however, mechanisms causig the inhibition and the relationships between the inhibition and the characteristics of the relaxants are not yet clearly established. Further elucidation using morphological and biochemical approaches will be necessary to better understand this phenomenon.

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Author information

Authors and Affiliations

  1. Department of Anesthesiology, Surugadai Nihon University Hospital, 1-8-13 Kanda Surugadai, Chiyoda-ku Tokyo, 101, Japan

    Hajime Suzuki

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  1. Hajime Suzuki
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Editors and Affiliations

  1. Department of Anesthesiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160, Japan

    Kazuaki Fukushima M.D., Ph.D (Professor and Chairman) & Ryoichi Ochiai M.D., Ph.D (Professor and Chairman) & 

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© 1995 Springer Japan

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Suzuki, H. (1995). Presynaptic Neuromuscular Blockade. In: Fukushima, K., Ochiai, R. (eds) Muscle Relaxants. Springer, Tokyo. https://doi.org/10.1007/978-4-431-66896-1_19

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  • DOI: https://doi.org/10.1007/978-4-431-66896-1_19

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-66898-5

  • Online ISBN: 978-4-431-66896-1

  • eBook Packages: Springer Book Archive

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