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Effects Other than Relaxation of Non-Depolarizing Muscle Relaxants

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Muscle Relaxants

Abstract

It is important that anesthesiologists be aware of the possible side effects of the muscle relaxants (MR) they use. Although several reviews have dealt with this subject (Paton, 1959; Foldes, 1960; Bowman, 1982; 1990; Hunter, 1987; Miller, 1992; Lien, 1994), they mainly summarized the unwanted effects of MRs from the clinical point of view and paid little attention to the mechanism of these actions, despite the fact that not infrequently the lack of such knowledge has led to improper selection of muscle relaxants (MR) and subsequently to operative and postoperative complications.

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References

  • References

    Google Scholar 

  • Alkonkon, M. and Albuquerque, E.X. (1993) Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. J. Pharmacol. Exp. 265:1455–1473.

    Google Scholar 

  • Anand, R., Conroy, W.G., Schoepter, R., Whiting, P. and Lindstrom, I. (1991) Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocyles have a pentameric quaternary structure. J. Biol. Chem. 266:11192–11198.

    PubMed  CAS  Google Scholar 

  • Beranek, R. and Vyskocil, F. (1967) The action of tubocurarine and atropine on normal and denervated rat diaphragm. J. Physiol. (Lond) 188:53–66.

    CAS  Google Scholar 

  • Bowman, W.C. (1980) Prejunctional and postjunctional cholinoceptors at the neuromuscular junction. Anesth. and Analg. 59: 935–943.

    CAS  Google Scholar 

  • Bowman, W.C. (1990) Pharmacology of neuromuscular function. John Wright, Bristol.

    Google Scholar 

  • Bowman, W.C. (1982) Non-relaxant properties of neuromuscular blocking drugs. Br.J.Anaesth. 54:147–160.

    Article  PubMed  CAS  Google Scholar 

  • Bowman, W.C. and Webb, S.N. (1972) Neuromuscular blocking and ganglion blocking activities of some acetylcholine antagonists in the cat. J. Pharm. Pharmacol. 24:762–772.

    Article  PubMed  CAS  Google Scholar 

  • Bowman, W.C. and Webb, S.N. (1976) Tetanic fade during partial transmission failure produced by non-depolarizing neuromuscular blocking drugs in the cat. Clin.Exp. Pharmacol. Physiol. 3:545–555.

    Article  PubMed  CAS  Google Scholar 

  • Cardone, C., Szenohradszky, J., Yost, S. and Bickler, P.E. (1994) Activation of brain acetylcholine receptors by neuromuscular blocking drugs. Anesthesiology, 80:1155–1161.

    Article  PubMed  CAS  Google Scholar 

  • Clarke, R.S.J, and Mirakhur, R.K. (1994) Adverse effect of muscle relaxants. Adverse Drug React. Toxicol. Rev. 13:23–41.

    PubMed  CAS  Google Scholar 

  • Coleman, A.J., Downing, J.W., Leary, W.P., Moyes, D.G. and Styles, M. (1972) The immediate cardiovascular effects of pancuronium, alcuronium and tubocurarine in man. Anesthesia 27:415–422.

    Article  CAS  Google Scholar 

  • Dashief, R.M. (1985) d-Tubocurarine causes neuronal death when injected directly into the rat brain. Exp. Neurol. 89:172–188.

    Article  Google Scholar 

  • Docherty, J.R., and McGrath, J.C., (1980) A comparison of the effects of pancuronium bromide and its monoquaternary analogue, Org NC 45, on autonomic and somatic neurotransmission in the rat. Br. J. Pharmacology, 71, 225.

    Article  CAS  Google Scholar 

  • Docherty, J.R., and McGrath, J.C., (1978) Sympathomimetic effects of pancuronium bromide on the cardiovascular system of the pithed rat: a comparison with the effects of drugs blocking the neuronal uptake of noradrenaline. Br.J. Pharmacology, 64, 589.

    Article  CAS  Google Scholar 

  • Feldberg, W., Malcolm, J.L. and Sherwood, S.L (1956) Some effects of tubocurarine on electrical activity of cats brain. J.Physiol. (Lond.) 132:130–137.

    CAS  Google Scholar 

  • Foldes, F.F. (1960) The pharmacology of neuromuscular blocking agents in man. Clin.Pharmacol. Ther. 3:345–395.

    Google Scholar 

  • Foldes, F.F., Kobayashi, O., Kinjo, M., Hársing, LG.Jr, Nagashima, H., Duncalf, D., Goldiner, P.L. and Vizi, E.S. (1989) Presynaptic effect of muscle relaxants on the release of 3H-norepinephrine controlled by endogenous acetylcholine in guinea pig atrium. J.Neural Transm. 76:169–180.

    Article  PubMed  CAS  Google Scholar 

  • Galindo, A.. (1971) Prejunctional effect of curare: its relative importance. J.Neurophysiol. 34:289–301.

    PubMed  CAS  Google Scholar 

  • Grady, S., Marks, M.J., Wonnacott, S. and Collins, A.C. (1992) Characterization of nicotinic receptor-mediated [Hjdopamine release from synaptosomes prepared from mouse striatum. J.Neurochem. 59:848–856.

    Article  PubMed  CAS  Google Scholar 

  • Hubbard, J.I. and Wilson, D.F. and Miyamoto, M. (1969) Reduction of transmitter release by d-tubocurarine. Nature 223:531–532.

    Article  PubMed  CAS  Google Scholar 

  • Hunter, J.M. (1987) Adverse effects of neuromuscular blocking drugs. Br.J.Anaesth. 59:46–60.

    Article  PubMed  CAS  Google Scholar 

  • Ivankovich, A.D., Miletich, D.J., Albrecht, R.F., and Zahed, G. (1975) The effect of pancuronium on myocardial contraction and catecholamine metabolism. J. Pharm. Pharmacol., 27, 837.

    Article  PubMed  CAS  Google Scholar 

  • Kharkevits, D.A. (1986) Adamantyl compounds. In: Kharkevits, D.A. (Eds) New Neuromuscular Blocking Agents, pp. 473–478. Springer-Verlag. Berlin, Heidelberg, New York, Tokyo.

    Chapter  Google Scholar 

  • Kharkevich, D.A. and Shorr, V.A. (1986) Antimuscarinic and ganglion-blocking activity of neuromuscular blocking agents, In New Neuromuscular blocking agents (D.A Kharkevich, ed.) Springer Verlag, Berlin, 193–224.

    Chapter  Google Scholar 

  • Kinjo, M., Nagashima, N. and Vizi, E.S. (1989) Effect of atracurium and laudanosine on the release of 3H-noradrenaline. Br. J. Anaesth. 62:683–690.

    Article  PubMed  CAS  Google Scholar 

  • Kobayashi, O., Nagashima, H., Duncalf, D., Chaudhry, I.A., Harsing, L.G. Jr. Foldes, F.F., Goldiner, P.L. and Vizi, E.S. (1987) Direct evidence that pancuronium and gallamine enhance the release of norepinephrine from the atrial sympathetic nerve by inhibiting prejunctional muscarinic receptors. J. of Autonomic Nerv. System 18:55–60.

    Article  CAS  Google Scholar 

  • Langley, J.N. (1905) On the reactions of cells and of nerve endings to certain poisons, chiefly as regards the reaction of striated muscle to nicotine and to curari. J.Physiol.(Lond.) 33:374–413.

    Google Scholar 

  • Lee Son, S. and Waud, B.E. (1977) Potencies of neuromuscular blocking agents at the receptors of the atrial pacemaker and motor endplate of the guinea-pig. Anesthesiology 47:34–36.

    Article  Google Scholar 

  • Lee Son, S. and Waud, B.E. (1978) A vagolytic action of neuromuscular blocking agents at the pacemaker of the isolated guinea-pig atrium. Anesthesiology 48:191–194.

    Article  Google Scholar 

  • Lee Son, S. and Waud, D.R. (1980) Effects of non-depolarizing blocking agents on the cardiac vagus nerve in the guinea-pig. Br. J.Anaesthesia 52:981–986.

    Article  Google Scholar 

  • Lien, C.A. (1994) Rational use of muscle relaxants. Anesth. and Analg. (Suppl) pp.66–72.

    Google Scholar 

  • Manabe, N., Kinjo, M., Chaudhry, I.A., Goldiner, P.L, and Foldes, F.F. (1988) The effect of pancuronium on the release of acetylcholine from the right atrium of the guinea-pig. Anesthesiology 69:A517.

    Article  Google Scholar 

  • Marshall, R.J. (1980) Actions of non-depolarizing neuromuscular blocking agents at cholinoceptors other than at the motor endplate. In: Curares and Curahsation. (C.Conseiller, ed.) Labraire Arnette, Paris 257–274. interaction

    Google Scholar 

  • Marshall, R.J. and Ojewole, J.A.O. (1979) Comparison of the autonomic effects of some currently used neuromuscular blocking agents. Br.J.Pharmacol. 66:77–78.

    Article  Google Scholar 

  • Matkó, I., Fehér, E. and Vizi, E.S. (1994) Receptor mediated presynaptic modulation of the release of noradrenaline in human papillary muscle. Cardiovasc. Res. 28:700–704.

    Article  PubMed  Google Scholar 

  • McGrath, J.C., Miller, R.D., Docherty, J.R., and Hamar, J.-C, (1980) Comparison of the cardiovascular actions of Org NC45 with those produced by other nondepolarizing neuromuscular blocking agents in experimental animals. Br. J. Anesth., 52:21 S.

    Article  Google Scholar 

  • Muscholl, E. (1980) Peripheral muscarinic control of norepinephrine release in the cardiovascular system. Am. J. Physiol. 239: H713–720.

    Google Scholar 

  • Nagashima, H., Vizi, E.S., Kobayashi, O., Kinjo, M., Duncalf, D., Goldiner, P.L, Foldes, F.F. (1986) Atracurium and laudanosine increase H-norepinephrine release from guinea pig atrium. Anesthesiology 65:A413.

    Article  Google Scholar 

  • Paton, W.D.M. (1957) Histamine release by compounds of simple chemical structure. Pharmacol. Rev. 9:169–187.

    Google Scholar 

  • Paton, W.D.M. (1959) The effects of muscle relaxants other than muscular relaxation. J.Anesth. 20:453–463.

    Article  CAS  Google Scholar 

  • Rapier, C, Lunt, G.G. and Wonnacott, S. (1990) Nicotinic modulation of [3H]dopamine release from striatal synaptosomes: pharmacological characterization. J.Neurochem. 54:937–945.

    Article  PubMed  CAS  Google Scholar 

  • Riker, W.F. and Wescoe, W.C. (1951) Pharmacology of Flaxedil with observations on certain analogues. Ann.N.Y. Acad. Sci. 54:373–377.

    Article  PubMed  CAS  Google Scholar 

  • Salt, P.J., Barnes, P.K. and Conway, CM. (1980) Inhibition of neuronal uptake of noradrenaline in the isolated perfused rat heart by pancuronium and its analogues, Org 6368, Org 7268 and NC 45. Br.J. Anaesthesia 52:313–317.

    Article  CAS  Google Scholar 

  • Sargent, P.B. (1993) The diversity of neuronal nicotinic acetylcholine receptors. Annu. Rev. Neurosci. 16:403–443.

    Article  PubMed  CAS  Google Scholar 

  • Seguela, P. Wadiche, J. Dineley-Miller K., Dani J.A. and Patrick, J.W. (1993) Molecular cloning, functional properties, and distribution of rat brain α7: a nicotinic cation channel highly permeable to calcium. J Neurosci. 13:596–604.

    CAS  Google Scholar 

  • Smith, S.M. Brown, H.O., Toman, J.E.P. and Goodman, L (1947) Lack of cerebral effects of d-tubocurarine. Anesthesiology 8:1–9. Somogyi, G.T. Vizi, E.S., Chaudhry, L.A., Nagashima H., Duncalf.D., Foldes F.F. and Goldiner, P.L. (1987) Modulation of stimulation-evoked release of newly formed acetylcholine from mouse hemidiaphragm preparation. Naunyn Schmiedeberg’s Arch. Pharmacol. 336:11–15.

    Google Scholar 

  • Somogyi, G.T. and Vizi, E.S. (1987) Positive and negative feedback modulation of CaO-dependent release of acetylcholine from mouse hemidiaphragm preparation. J. Physiol., 390:176.

    Google Scholar 

  • Stoelting, R.K. (1973) Hemodynamic effects of gallamine during halothane-nitrons oxide anaesthesia. Anesthesiology 39:645–647.

    Article  PubMed  CAS  Google Scholar 

  • Storella, R.J., Timothy, S., Ackerman, B.S., Ziad, J. and Katul, B.S. (1993) Tetanic fade and acetylcholine release. Anesthesiology 79: A923.

    Article  Google Scholar 

  • Szenohradszky, J., Trevor, A.J., Bickler, P., Caldwell, J.E., Sharma, M.L., Rampil, I.J. and Miller, R.D. (1993) Central nervous system effects of intrathecal muscle relaxants in rats. Anesth. Analg. 76:1304–1309.

    PubMed  CAS  Google Scholar 

  • Todorov, L., Windisch, K., Sershen, H., Papasova, M. and Vizi, E.S. (1991) Prejunctional nicotinic receptors involved in facilitation of stimulation-evoked noradrenaline release from the vas deferens. Br. J.Pharmacol. 102:186–190.

    Article  PubMed  CAS  Google Scholar 

  • Torocsik, A., Oberfrank, F., Sershen, H., Lajtha, A., Nemessy, K. and Vizi, E.S. (1991) Characterization of somatodendritic neuronal nicotinic receptors located on the myenteric plexus. Eur. J. Pharmacol. 202:297–302.

    Article  PubMed  CAS  Google Scholar 

  • Torocsik, A., Oberfrank, F., Sershen, H., Lajtha, A., Nemessy, K. and Vizi, E.S. (1991) Characterization of somatodendritic neuronal nicotinic receptors located on the myenteric plexus. Eur. J. Pharmacol. 202:297–302.

    Article  PubMed  CAS  Google Scholar 

  • Vemallis, A.B., Conroy, W.G. and Berg, D.X. (1993) Neurons assemble acetylcholine receptors with as many as three kinds of subunits while maintaining subunit regregation among receptor subtypes. Neuron, 10:451–464.

    Article  Google Scholar 

  • Vizi, E.S. (1973) Acetylcholine release from guinea-pig ileum by parasympathetic ganglion stimultants and gastrin-like polypeptides. Br. J. Pharmacol. 47:765–777.

    Article  PubMed  CAS  Google Scholar 

  • Vizi, E.S. (1984) Non-synaptic Interactions Between Neurons: Modulation of Neurochemical Transmission. John Wiley and Sons, Chichester.

    Google Scholar 

  • Vizi, E.S. and Labos, E. (1989) Nonsynaptic interactions at pressynaptic level. Progr. in Neurobiol. 37:145–163.

    Google Scholar 

  • Vizi, E.S., Gyires, K., Somogyi, G.T. and Ungvah, G. (1983) Evidence that transmitter can be released from regions of the nerve cell other than presynaptic axon terminal axonal release of acetylcholine without modulation. Neuroscience 10:967–972.

    Article  PubMed  CAS  Google Scholar 

  • Vizi, E.S., Kobayashi, O., Torocsik, A., Kinjo, M., Manabe, N., Goldioner, P.L., Potter, P.E. and Földes, F.F. (1989) Heterogeneity of presynaptic muscarinic receptors involved in modulation of transmitter release. Neuroscience 31:259–267.

    Article  PubMed  CAS  Google Scholar 

  • Vizi, E.S., Kobayashi, O., Manabe, N., Nagashima, H., Foldes, F.F. (1990) Mechanism of the gallamine and pancuronium induced elevation of heart rate in guinea pigs. Anesth. Analg. 70:S450.

    Article  Google Scholar 

  • Vizi, E.S., Somogyi, G.T., Nagashima, H., Duncalf, D., Chaudhry, I.A., Kobayashi, O. and Foldes, F.F. (1987) d-Tubocurahne and Pancuronium inhibit evoked release of acetylcholine from the mouse hemidiaphraghm preparations. Br.J. Anaesth. 59:226–231.

    Article  PubMed  CAS  Google Scholar 

  • Vizi, E.S., Somogyi, G.T., Nagashima, H., Duncalf, D., Chaudhry, I.A., and Foldes, F.F. (1985) d-Tubocurarine and pancuronium inhibitevoked release of acetycholine. Anesthesiology 63:A328.

    Article  Google Scholar 

  • Vizi, E.S., Sershen, H., Baila, A., Mike, A., Windisch, K., Juranyi, Zs., and Lajtha, A. (1994) Neurochemical evidence of heterogeneity of presynaptic and somatodendritic nAChRs. Ann. N.Y. Acad. Sci. (in press).

    Google Scholar 

  • Ward, S., Boheimer, N., Weatherley, B.C., Simmonds, R.J. and Depson, T.A. (1987) Pharmacokinetics of atracuhum and its metabolites in patients with normal renal function, and in patients in renal failure. Brit. J. Anaesthesia 59:697–706.

    Article  CAS  Google Scholar 

  • Whiting, P. and Lindstrom, J. (1987) Purification and characterization of a nicotinic acetylcholine receptor from rat brain. Proc. Natl. Acad. Sci. USA 84:595–599.

    Article  PubMed  CAS  Google Scholar 

  • Wessler, I., Karl, M., Mai, M. and Diener, A. (1987) Muscarine receptors on the rat phrenic nerve, evidence for positive and negative feedback mechanisms. Naunyn-Schmiedebergs Arch. Pharmacol. 335:605–612.

    Article  PubMed  CAS  Google Scholar 

  • Wessler, I. and Kilbinger, H. (1986) Release of [3H]-acetylcholine from a modified rat phrenic nerve hemidiaphragm preparation, Naunyn-Schmiedebergs Arch. Pharmacol. 334:357–364.

    Article  PubMed  CAS  Google Scholar 

  • Yu, Z.J. and Wecker, L. (1994) Chronic nicotine administration differentially affects neurotransmitter release from rat striatal slices. J.Neurochem., 63:186–194.

    Article  PubMed  CAS  Google Scholar 

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Vizi, E.S. (1995). Effects Other than Relaxation of Non-Depolarizing Muscle Relaxants. In: Fukushima, K., Ochiai, R. (eds) Muscle Relaxants. Springer, Tokyo. https://doi.org/10.1007/978-4-431-66896-1_10

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  • DOI: https://doi.org/10.1007/978-4-431-66896-1_10

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