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Management of the Patients with Feature of Autoimmune Hepatitis

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Autoimmune Liver Diseases

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Abstract

Primary biliary cirrhosis (PBC) and autoimmune hepatitis (AIH) differ in clinical, laboratory, and histological features, as well as response to therapy. Some patients with PBC present with characteristic features of AIH; however, there is no formal designation for conditions in which features of PBC and AIH overlap (PBC-AIH overlap syndrome). The pathogenesis of PBC-AIH overlap syndrome is not well understood and its diagnosis is challenging. The International Autoimmune Hepatitis Group (IAIHG) scoring system for the diagnosis of AIH has been widely used to describe PBC-AIH overlap syndrome, but has not been proven to be appropriate for this purpose. Due to the low prevalence of this disorder, recommendations on therapy focus on treatments available for each individual disorder and on findings from retrospective, non-randomized studies. The aim of this report is to provide a current overview of the clinical and histological features, diagnosis, treatment, and prognosis of PBC-AIH overlap syndrome.

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Authors and Affiliations

  1. Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima, 960-1295, Japan

    Kazumichi Abe, Atsushi Takahashi & Hiromasa Ohira

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  1. Kazumichi Abe
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  2. Atsushi Takahashi
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  3. Hiromasa Ohira
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Correspondence to Kazumichi Abe .

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  1. Dept of Gastroenterology & Rheumatology, Fukushima Medical University of Medicine, Fukushima, Japan

    Hiromasa Ohira

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Abe, K., Takahashi, A., Ohira, H. (2014). Management of the Patients with Feature of Autoimmune Hepatitis. In: Ohira, H. (eds) Autoimmune Liver Diseases. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54789-1_20

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  • DOI: https://doi.org/10.1007/978-4-431-54789-1_20

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