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Autoimmune Liver Diseases

Perspectives from Japan

  • Hiromasa¬†Ohira

Table of contents

  1. Front Matter
    Pages i-viii
  2. Autoimmune Hepatitis

    1. Front Matter
      Pages 1-1
    2. Hiroki Takahashi
      Pages 3-20
    3. Norihiko Watanabe, Aki Ikeda
      Pages 21-35
    4. Kaname Yoshizawa, Akihiro Matsumoto, Takeji Umemura
      Pages 37-44
    5. Mikio Zeniya
      Pages 67-81
    6. Masanori Abe, Morikazu Onji
      Pages 83-94
    7. Yasuhiro Miyake
      Pages 95-106
    8. Teruko Arinaga-Hino, Tatsuya Ide, Michio Sata
      Pages 107-120
    9. Tomoo Fujisawa
      Pages 121-126
    10. Atsushi Takahashi, Kazumichi Abe, Hiromasa Ohira
      Pages 127-136
    11. Takeji Umemura
      Pages 137-143
  3. Primary Biliary Cirrhosis

    1. Front Matter
      Pages 145-145
    2. Yuki Moritoki, Yoshiyuki Ueno
      Pages 171-199
    3. Junko Hirohara, Toshiaki Nakano, Toshihito Seki, Kazuichi Okazaki, Kenichi Harada, Hiromi Ishibashi et al.
      Pages 201-213
    4. Yuko Kakuda, Kenichi Harada, Yasuni Nakanuma
      Pages 215-232
    5. Atsumasa Komori
      Pages 233-247
    6. Kazumichi Abe, Atsushi Takahashi, Hiromasa Ohira
      Pages 277-286
    7. Takuya Genda, Takafumi Ichida
      Pages 287-300
  4. Back Matter
    Pages 301-305

About this book

Introduction

Autoimmune Liver Diseases summarizes the recent high-impact research and clinical findings obtained in Japan in the study and treatment of autoimmune liver diseases. Although these disorders are relatively rare, they are recognized as an important group of refractory liver diseases, the most common of which are autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC). The book therefore comprises two major sections, one dealing with AIH, the other with PBC.

AIH in Japanese patients creates a unique disease population, as its clinical features are different from those of Western patients resulting from the different genetic background of the two patient populations. Also, mouse models of neonatal thymectomy-PD-1 knockout mice, clinical analyses of acute hepatitis-like manifestations, and research findings on IgG4-related autoimmune hepatitis have been reported in Japan and are included in this book. A disease-susceptibility gene specific to Japanese PBC patients has also recently been discovered. Because of the relatively homogeneous population of Japan, analyses conducted with Japanese PBC patients have yielded findings that are highly relevant to the pathogenesis of the disease.

Furthermore, new pathological staging criteria, anti-gp210 antibodies and the basis they provide for improved accuracy of prognosis, treatment with bezafibrate, and the outcomes of living-donor liver transplantation are also presented here. This volume therefore serves as a useful resource not only for hepatologists, but also for researchers, clinical residents, and medical students both in Japan and in other countries.

Keywords

AIH PBC autoimmune hepatitis primary biliary cirrhosis

Editors and affiliations

  • Hiromasa¬†Ohira
    • 1
  1. 1.Dept of Gastroenterology & RheumatologyFukushima Medical University of MedicineFukushimaJapan

Bibliographic information

  • DOI https://doi.org/10.1007/978-4-431-54789-1
  • Copyright Information Springer Japan 2014
  • Publisher Name Springer, Tokyo
  • eBook Packages Medicine
  • Print ISBN 978-4-431-54788-4
  • Online ISBN 978-4-431-54789-1
  • Buy this book on publisher's site
Industry Sectors
Pharma
Biotechnology