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Bioreaktoren

  • Chapter
Bioprozesstechnik

Zusammenfassung

Die industrielle Verwertung Erfolg versprechender Bioreaktionen scheitert oft an der Übertragung der Ergebnisse vom Schüttelkolben in den m3-Maßstab. Der technischen Auslegung des hierfür notwendigen Reaktors sowie der Produktisolation und -reinigung sind deshalb die folgenden Kapitel gewidmet (7 bis 12).

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Literatur

  • Adler, I. (1986): Valuation of bioreactors for low viscous media and high oxygen transfer demand. Bioproc. Eng. 1: 51–59

    Article  Google Scholar 

  • Adler, I., Fiechter, A. (1983): Charakterisierung von Bioreaktoren mit biologischen Testsystemen. Chem.-Ing.-Tech. 4: 322–323

    Article  Google Scholar 

  • Anderlei, T., Büchs, J. (2001): Device for sterile online measurement of the oxygen transfer rate in shaking flasks. Biochem. Eng. J. 7: 157–162

    Article  PubMed  CAS  Google Scholar 

  • Anderlei, T., Zang, W., Papaspyrou, M., Büchs, J. (2004): Online respiration activity measurement (OTR, CTR, RQ) in shake flasks. Biochem. Eng. J. 17: 187–194

    Article  CAS  Google Scholar 

  • Anton, F., Suck, K., Diederichs, S., Behr, L., Hitzmann, B., van Griensven, M., Scheper, T., Kasper, C. (2008): Design and characterization of a rotating bed system bioreactor for tissue engineering applications. Biotechnol. Prog. 24: 140–147

    Article  PubMed  CAS  Google Scholar 

  • Behie, L. A., Kalogerakis, N., Gaucher, G. M. (1987): The Application of Continous Three Phase Fluidized Bed Bioreactors to the Production of Pharmaceuticals. In: Chmiel, H., Hammes, W. P., Bailey, J. E. (Hrsg.): Biochemical Engineering. Gustav Fischer Verlag, Stuttgart

    Google Scholar 

  • Blenke, H. (1979): Loop reactors. Adv. Biochem. Eng. 13: 121–214

    Google Scholar 

  • Blenke, H. (1984): Strömung, Dispergierung und Stoffübertragung bei G-L-Systemen in Schlaufenreaktoren. Preprints „Technik der Gas-Flüssig-und der Dreiphasenströmung“. GVC VDI-Gesellschaft Verfahrenstechnik und Chemieingenieurwesen

    Google Scholar 

  • Blenke, H. (1985): Biochemical Loop Reactors. In Biotechnology Vol. 2, VCH Verlagsgesellschaft, Weinheim

    Google Scholar 

  • Blenke, H. (1987): Process engineering contributions to bioreactor design and operation. In: Chmiel, H., Hammes, W. P., Bailey, J. E. (Hrsg.): Biochemical Engineering. Gustav Fischer Verlag, Stuttgart

    Google Scholar 

  • Blenke, H. (1988): Verfahrenstechnische Beiträge zur Entwicklung von Bioreaktoren. BTF Biotech-Forum 1: 5

    Google Scholar 

  • Buchenauer, A., Funke, M., Büchs, J., Mokwa, W., Schnakenberg, U. (2009): Microbioreactors with microfluidic control and a user-friendly connection to the actuator hardware. J. Micromech. Microeng. 19: 074012 (8pp)

    Article  Google Scholar 

  • Chu, L., Robinson, D. K. (2001) Industrial choices for protein production by large-scale cell culture. Curr. Opin. Biotechnol. 12: 180–187

    Article  PubMed  CAS  Google Scholar 

  • Dhariwal (2007): The significance of submerged ceramic membrane systems for production oriented bioprocesses. Dissertation, Universität des Saarlandes

    Google Scholar 

  • Diederichs, S., Freiberger, F., van Griensven, M. (2009): Effects of Repetitive and Short Time Strain in Human Bone Marrow Stromal Cells. J Biomed Mater Res A 88: 907–915

    PubMed  Google Scholar 

  • Eibl, R., Eibl, D. (2009): Application of disposible bag bioreactors in tissue engineering and for the production of therapeutic agents. Adv. Biochem. Engin./Biotechnol. 112: 183–207

    Article  CAS  Google Scholar 

  • Funke, M., Buchenauer, A., Schnakenberg, U., Mokwa, W., Diederichs, S., Mertens, A., Müller, C., Kensy, F., Büchs, J. (2010): Microfluidic BioLector-Microfluidic Bioprocess Control in Microtiter Plates. Biotechnol. Bioeng. 107:497–505

    Article  PubMed  CAS  Google Scholar 

  • Furchner, B. (1988): Die Zerstörung wässriger Tensidschäume durch rotierende Einbauten. Dissertation, Technische Universität München

    Google Scholar 

  • Gebauer, A. (1985): Untersuchungen zum Wachstum und zur Enzymproduktion von E. coli. Dissertation, Universität Hannover

    Google Scholar 

  • Geisler, R. K. (1991): Fluiddynamik und Leistungseintrag in turbulent gerührten Suspensionen, Dissertation TU München

    Google Scholar 

  • Gruber, T., Chmiel, H., Käppeli, O., Sticher, P., Fiechter, A. (1993): Integrated process for continuous rhamnolipid biosynthesis. In: Kosaric, N. (Hrsg.) Biosurfactants. Production — Properties — Applications. Surfactant Science Series, Vol. 48. Marcel Dekker, Inc., New York, 157–173

    Google Scholar 

  • Heijnen, J. J. (1984): Technik der anaeroben Abwasserreinigung. Chem.-Ing.-Tech. 56: 526–532

    Article  CAS  Google Scholar 

  • Henkel, H. J. (1992): Reaktionstechnische Untersuchung eines Dreiphasenfließbettreaktors..., Dissertation, Universität Stuttgart

    Google Scholar 

  • Henzler, H.-J. (1982): Verfahrenstechnische Auslegungsunterlagen für Rührbehälter als Fermenter. Chem.-Ing.-Tech. 5: 461–476

    Article  Google Scholar 

  • Hiby, J. W. (1979): Definition und Messung der Mischgüte in flüssigen Gemischen. Chem.-Ing.-Tech. 7: 704–709

    Article  Google Scholar 

  • Hortsch, R., Stratmann, A., Weuster-Botz, D. (2010): New milliliter-scale stirred tank bioreactors for the cultivation of mycelium forming microorganisms. Biotechnol. Bioeng. 106: 443–451

    PubMed  CAS  Google Scholar 

  • Hortsch, R., Weuster-Botz, D. (2010): Power consumption and maximum energy dissipation in a milliliter-scale bioreactor. Biotechnol. Prog. 26: 595–599

    PubMed  CAS  Google Scholar 

  • Hortsch, R. (2011): Miniaturisierte Rührreaktoren zur Kultivierung morphologisch veränderlicher Mikroorganismen. Dissertation TU München, Lehrstuhl für Bioverfahrenstechnik

    Google Scholar 

  • Huber, R., Ritter, D., Hering, T., Hillmer, A.-K., Kensy, F., Müller, C., Wang, L., Büchs, J. (2009): Robo-Lector — a novel platform for automated high-throughput cultivations in microtiter plates with high information content. Microbial Cell Factories 8: 42

    Article  PubMed  Google Scholar 

  • Jaramillo, A. (1985): Fluid dynamic and oxygen transfer during the cultivation of Trichosporon cutaneum in jet loop bioreactors. Dissertation Nr. 7899, ETH Zürich

    Google Scholar 

  • Jeude, M., Dittrich, B., Niederschulte, H., Anderlei, T., Knocke, C., Klee, D., Büchs. J. (2006): Fed-batch mode in shake flasks by slow-release technique. Biotechnol. Bioeng. 95: 433–445

    Article  PubMed  CAS  Google Scholar 

  • Judat, H. (1976): Zum Dispergieren von Gasen. Dissertation, Universität Dortmund

    Google Scholar 

  • Judat, H. (1982): Stoffaustausch Gas/Flüssigkeit im Rührkessel — eine kritische Bestandsaufnahme. Chem.-Ing.-Tech. 5: 520–521

    Article  Google Scholar 

  • Karrer, D. (1978): Der total gefüllte Bioreaktor. Optimierung, physikalisch-chemische und biologische Charakterisierung. Dissertation Nr. 6254, ETH Zürich

    Google Scholar 

  • Kaskas, A. (1969): Partikelbewegung bei der Sedimentation von Mehrkornsuspensionen. Chem.-Ing.-Tech. 18

    Google Scholar 

  • Kasper, C. (2005): Tissue Engineering; Ersatzteillager Mensch. Chem. Unserer Zeit 39: 394–401

    Article  CAS  Google Scholar 

  • Kasper, C., van Griensven, M., Pörtner, M. (2009): Bioreactor systems for tissue engineering. Biochem. Eng. Technol. 112: 1–271

    Google Scholar 

  • Kensy, F., Engelbrecht, C., Büchs, J. (2009a): Scale-up from microtiter plate to laboratory fermenter: evaluation by online monitoring techniques of growth and protein expression in Escherichia coli and Hansenula polymorpha fermentations. Microbial Cell Factories 8: 68

    Article  PubMed  Google Scholar 

  • Kensy, F., Zang, E., Faulhammer, C., Tan, R.-K., Büchs, J. (2009b): Validation of a high-throughput fermentation system based on online monitoring of biomass and fluorescence in continuously shaken microtiter plates. Microbial Cell Factories 8: 31

    Article  PubMed  Google Scholar 

  • Kintzios, S., Makri, O., Pistola, E., Matakiadis, T., Shi, H. P., Economou, A. (2004): Scale-up production of puerarin from hairy roots of Pueraria phaseoloides in an airlift bioreactor. Biotechnol. Lett. 26: 1057–1059

    Article  PubMed  CAS  Google Scholar 

  • Kipke, K. (1985a): Rührtechnische Auslegungsaspekte von Industriefermentern. Biotech-Forum 2: 65–72

    Google Scholar 

  • Kipke, K. (1985b): Auslegung von Industrierührwerken. Chem.-Ing.-Tech. 57: 813–823

    Article  CAS  Google Scholar 

  • Knorr, B., Schlieker, H., Hohmann, H. P., Weuster-Botz, D. (2007): Scale-down and parallel operation of the riboflavin production process with Bacillus subtilis. Biochem. Eng. J. 33: 263–274

    Article  CAS  Google Scholar 

  • Kolla, M. (1984): Vergleich des Stoffübergangs beim Wachstum einer Hefe und eines Bakteriums im Airlift-Schlaufenfermenter. Dissertation, Universität Dortmund

    Google Scholar 

  • Krahe, M. (2000): Biochemical Engineering. Ullmann’s Encyclopedia of Industrial Chemistry

    Google Scholar 

  • Kraume, M. (2002): Mischen und Rühren, Grundlagen und moderne Verfahren, Wiley-VCH Verlag, Weinheim

    Book  Google Scholar 

  • Kresta, S. M., Wood, P. E. (1993): The flow field produced by a pitched blad turbine, Characterization of the turbulence and estimation of the dissipation rate. Chem. Eng. Sci. 48: 1761–1774

    Article  CAS  Google Scholar 

  • Kusterer, A., Krause, C., Kaufmann, K., Arnold, M., Weuster-Botz, D. (2008): Fully automated single-use stirred-tank bioreactors for parallel microbial cultivations. Bioprocess Biosys. Eng. 31: 207–215

    Article  CAS  Google Scholar 

  • Linek, V., Vacek, V. (1986): Recommended procedure for the measurement of the volumetric mass transfer coefficient kLa in aerated agitated vessels. Report for the Working Party on Mixing of EFChE, Prague Inst. Chem. Technology

    Google Scholar 

  • Lohmann, T., Pahl, M. H. (1993): Mechanische Schaumzerstörung feststoffhaltiger Schäume. Chem.-Ing.-Tech. 11: 1362–1365

    Article  Google Scholar 

  • Manna, L. (1997): Comparison between physical and chemical methods for the measurement of mixing times. Chem. Eng. J. 67: 167–173

    Article  CAS  Google Scholar 

  • Märkl, H., Lechner, M., Götz, F. (1990): A new dialysis fermentor for the production of high concentrations of extracellular enzymes. J. Ferment. Bioeng. 69: 244–249

    Article  Google Scholar 

  • Martin, I., Wendt, D., Heberer, M. (2004): The role of bioreactors in tissue engineering. Trends Biotechnol. 22: 80–86

    Article  PubMed  CAS  Google Scholar 

  • Meusel, W. (1989): Beitrag zur Modellierung von Gas-Flüssigkeits-Reaktoren auf der Basis relevanter Mikroprozesse. Dissertation B, Ingenieurhochschule Köthen

    Google Scholar 

  • Naicker, M. (1999): Design and commissioning of the oscillatory mixer, Thesis Report, Department of Chemical Engineering University of Queensland

    Google Scholar 

  • Pierce, L. N., Shabram, P. W. (2004): Scalability of a disposable bioreactor from 12L–500L run in perfusion mode with a CHO-based cell line: A tech review. BioProcessing J. 3(4): 1–6

    Google Scholar 

  • Pörtner, R., Fassnacht, D., Märkl, H. (1999): Immobilization of mammalian cells in fixed bed reactors. BIOforum International 4: 140–141

    Google Scholar 

  • Posten, C. (2009): Design principles of photo-bioreactors for cultivation of microalgae. Engineering in Life Sciences 9: 145–177

    Article  Google Scholar 

  • Puskeiler, R., Weuster-Botz, D. (2004): Rührkesselreaktoren im mL-Maßstab: Kultivierung von Escherichia coli. Chem.-Ing.-Tech. 76: 1865–1869

    Article  CAS  Google Scholar 

  • Puskeiler, R., Kaufmann, K., Weuster-Botz, D. (2005): Development, parallelization, and automation of a gas-inducing milliliter-scale bioreactor for high-throughput bioprocess design (HTBD). Biotechnol. Bioeng. 89: 512–523

    Article  PubMed  CAS  Google Scholar 

  • Reule, W. (1983): Zur Sauerstoffübertragung im Strahl-Schlaufenreaktor mit dem Sulfitsystem. Dissertation, Universität Stuttgart

    Google Scholar 

  • Richardson, J. F., Zaki, W. N. (1954): Sedimentation and fluidisation. Part I. Trans. Instn. Chem. Engrs. 32: 35–53

    CAS  Google Scholar 

  • Richardson, J. F., Mirza, S. (1979): Sedimentation of suspensions of particles of two or more sizes. Chem. Eng. Sci. 34: 447–454

    Article  Google Scholar 

  • Riesenberg, D., Menzel, K., Schulz, V., Schumann, K., Veith, G., Zuber, G., Knorre, W. A. (1990): High cell-density fermentation of recombinant Escherichia coli expressing human interferon alpha 1. Appl. Microbiol. Biotechnol. 34: 77–82

    Article  PubMed  CAS  Google Scholar 

  • Samorski, M., Müller-Newen, G., Büchs, J. (2005): Quasicontinuous combined scattered light and fluorescence measurements: a novel measurement technique for shaken microtiter plates. Biotechnol. Bioeng. 92: 61–68

    Article  PubMed  CAS  Google Scholar 

  • Sandoval-Basurto, E. A., Gosset, G., Bolivar, F., Ramirez, O. T. (2005): Culture of Escherichia coli under dissolved oxygen gradients simulated in a two-compartment scaledown system: Metabolic response and production of recombinant protein. Biotechnol. Bioeng. 89: 453–463

    Article  PubMed  CAS  Google Scholar 

  • Scheidle, M., Jeude, M., Dittrich, B., Denter, S., Kensy, F., Suckow, M., Klee, D., Büchs, J. (2010): High-throughput screening of Hansenula polymorpha clones in batch compared to controlled-release fed-batch mode on small scale. FEMS Yeast Res. 10: 83–92

    Article  PubMed  CAS  Google Scholar 

  • Schügerl, K. (1989): Biofluidization: Application of the fluidization technique in biotechnology. Canad. J. Chem. Eng. 67: 178–184

    Article  Google Scholar 

  • Seipenbusch, R., Blenke, H. (1980): The loop reactor for cultivating yeast on n-paraffin substrate. Adv. Biochem. Eng. 15: 1–40

    Article  CAS  Google Scholar 

  • Seletzky, J. M., Noack, U., Fricke, J., Welk, E., Eberhard, W., Knocke, C., Büchs, J. (2007): Scale-up from shake flasks to fermenters in batch and continuous mode with Corynebacterium glutamicum on lactic acid based on oxygen transfer and pH. Biotechnol. Bioeng. 98: 800–811

    Article  PubMed  CAS  Google Scholar 

  • Siclaff, T. D, Hu, M. Z., Amiot, B., Rollins, M. D., Rao, S., McGuire, B., Bloomer, J. R., Hu, W. S., Cerra, F. B.(1995): Gel-entrapment bioartificial liver therapy in galactosamine hepatitis. J. Surg. Res. 59: 179–184

    Article  Google Scholar 

  • Sierra, E., Acien, F.G., Fernandez, J.M., Garcia, J.L., Gonzalez, C., Molina Grima, E. (2008): Characterization of a flat plate photobioreactor for the production of microalgae. Chem. Eng. J. 138(1–3): 136–147.

    Article  CAS  Google Scholar 

  • Stephens, E., Ross, I. L., King, Z., Mussgnug, J. H., Kruse, O., Posten, C., Borowitzka, M. A., Hankamer, B. (2010): An Economic and Technical Evaluation of Microalgal Biofueles. Nat. Biotechnol. 28(2): 4–6

    Article  Google Scholar 

  • Sternad, W. (1988): Beitrag zur Berechnung der Fluiddynamik von Mammut-Schlaufenreaktoren. Dissertation, Universität Stuttgart

    Google Scholar 

  • Sternad, W. (1991): Bioreaktoren. In: Chmiel. H. (Hrsg.) Bioprozeßtechnik. Fischer-Verlag

    Google Scholar 

  • Sternad, W., Blenke, H. (1986): Untersuchung und Optimierung von Schlaufenreaktor-Varianten. Abschlussbericht zum AIF-Forschungsprojekt 5363, Stuttgart

    Google Scholar 

  • Sternad, W., Blenke, H. (1989a): Zur Berechnung der Fluiddynamik von Mammut-Schlaufenreaktoren. Chem.-Ing.-Tech. 6: 479–482

    Article  Google Scholar 

  • Sternad, W., Blenke, H. (1989b): Hydrodynamische Schaumverhütung bei Gas-Liquid-Systemen. Forum Mikrobiologie 10: 465–473

    Google Scholar 

  • Stöckmann, C., Scheidle, M., Klee, D., Dittrich, B., Merckelbach, A., Hehmann, G., Melmer, G., Büchs, J., Kang, H. A., Gellissen, G. (2009): Process development in Hansenula polymorpha and Arxula adeninivorans, a re-assessment. Microbial Cell Factories 8: 22

    Article  PubMed  Google Scholar 

  • Stöckmann, C., Maier, U., Anderlei, T., Knocke, C., Gellissen, G., Büchs, J. (2003): The oxygen transfer rate as key parameter for the characterisation of Hansenula polymorpha screening cultures. J. Ind. Microbiol. Biotechnol. 30(10): 613–622

    Article  PubMed  Google Scholar 

  • Storhas, W. (1994): Bioreaktoren und periphere Einrichtungen, Vieweg Lehrbuch Biotechnologie

    Google Scholar 

  • Tredici, M. R. (2010): Photobiology of microalgae mass cultures: understanding the tools for the next green revolution. Biofuels 1(1): 143–162

    Article  CAS  Google Scholar 

  • Trick, I., Schneider, W., Sternad, W., Henkel, H. J., Trösch, W. (1989): Abwasserreinigung mit immobilisierten Mikroorganismen unter Verwendung von porösen, kugeligen Sinterglasträgern. Dechema-Jahrestagung der Biotechnologen, Frankfurt

    Google Scholar 

  • Trick, I., Sternad, W., Reuter, G., Johl, H. J., Gebicke, W., Trösch, W., Chmiel, H. (1991): Comparative investigations on the production of glutamic acid with Corynebacterium glutamicum in stirred tank and propeller loop reactors. In: Reuss, M., Chmiel, H., Gilles, E. D., Knackmuss, H.-J. (Hrsg.): Biochemical Engineering. Gustav Fischer Verlag, Stuttgart

    Google Scholar 

  • Timmins, N., Scherberich, A., Früh, J., Heberer, M., Martin, I., Jakob M. (2007): Three-dimensional cell culture and tissue engineering in a T-CUP (tissue culture under perfusion). Tissue Eng. 13: 2021–2028

    Article  PubMed  CAS  Google Scholar 

  • Vester, A., Hans, M., Hohmann, H. P., Weuster-Botz, D. (2009): Discrimination of riboflavin producing Bacillus subtilis strains based on their fed-batch process performances on a millilitre-scale. Appl. Microbiol. Biotechnol. 84: 71–76

    Article  PubMed  CAS  Google Scholar 

  • Wagner, B. (1987): Leistungsvergleich von Bioreaktoren für Mycelförmiges Wachstum. Dissertation Nr. 8225, ETH Zürich

    Google Scholar 

  • Weiland, P. (1984): Einflu das Betriebsverhalten von Airlift-Schlaufenreaktoren. Chem.-Ing.-Tech. 56: 64–65

    Article  CAS  Google Scholar 

  • Wendt, D., Jakob, M., Martin, I. (2005): Bioreactor-based engineering of osteochondral grafts: from model systems to tissue manufacturing. J. Biosci. Bioeng. 100: 489–494

    Article  PubMed  CAS  Google Scholar 

  • Weuster-Botz, D., Puskeiler, R., Kusterer, A., Kaufmann, K., John, G. T., Arnold, M. (2005): Methods and milliliter scale devices for high-throughput bioprocess design. Bioprocess Biosys. Eng. 28: 109–119

    Article  CAS  Google Scholar 

  • Yuan, Y.-J., Wie, Z.-J., Wu, Z.-L., Wu, J.-C. (2001): Improved taxol production in suspension cultures of Taxus chinensis var. mairei by in situ extraction combined with precursor feeding and additional carbon source introduction in an airlift loop reactor. Biotechnol. Lett. 23: 1659–1662

    Article  CAS  Google Scholar 

  • Zlokarnik, M. (1978): Sorption characteristics for gas-liquid contacting in mixing vessels. Adv. Biochem. Eng. 8: 133–151

    CAS  Google Scholar 

  • Zlokarnik, M. (1984): Auslegung und Dimensionierung eines mechanischen Schaumzerstörers. Chem.-Ing.-Tech. 11: 839–844

    Article  Google Scholar 

  • Zlokarnik, M. (1985): Tower-shaped reactors for aerobic biological waste water treatment. In: Rehm, H.-J., Reed, G. (Hrsg.) Biotechnology, Vol. 2. VCH Verlagsgesellschaft, Weinheim

    Google Scholar 

  • Zlokarnik, M. (1999): Rührtechnik. Springer-Verlag, Berlin

    Book  Google Scholar 

  • Zlokarnik, M. (2000a): Mixing, Ullmann’s Encyclopedia of Industrial Chemistry, Verlag Chemie, Weinheim, 6. Auflage, Vol. B2

    Google Scholar 

  • Zlokarnik, M. (2000b): Scale-up; Modellübertragung in der Verfahrenstechnik. Wiley-VCH, Weinheim

    Book  Google Scholar 

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Chmiel, H. (2011). Bioreaktoren. In: Chmiel, H. (eds) Bioprozesstechnik. Spektrum Akademischer Verlag, Heidelberg. https://doi.org/10.1007/978-3-8274-2477-8_7

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