Common Cold pp 77-106 | Cite as


  • Ian M. Mackay
  • Katherine E. Arden
  • Stephen B. Lambert
Part of the Birkhäuser Advances in Infectious Diseases book series (BAID)


The common cold is the result of an upper respiratory tract infection causing an acute syndrome characterised by a combination of non-specific symptoms, including sore throat, cough, fever, rhinorrhoea, malaise, headache, and myalgia. Respiratory viruses, alone or in combination, are the most common cause. The course f illness can be complicated by bacterial agents, causing pharyngitis or sinusitis, but the are a rare cause of cold and flu-like illnesses (CFLIs). Our understanding of CFLI epidemiology has been enhanced by molecular detection methods, particularly polymerase chain reaction (PCR) testing. PCR has not only improved detection of previously known viruses, but within the last decade has resulted in the detection of many divergent novel respiratory virus species. Human rhinovirus (HRV) infections cause nearly all CFLIs and they can be responsible for asthma and chronic obstructive pulmonary disease exacerbations. HRVs are co-detected with other respiratory viruses in statistically significant patterns, with HRVs occurring in the lowest proportion of co-detections, compared to most other respiratory viruses. Some recently identified rhinoviruses may populate an entirely new putative HRV species; HRV C. Further work is required to confirm a causal role for these newly identified viruses in CFLIs. The burden of illness associated with CFLIs is poorly documented, but where data are available, the impact of CFLIs is considerable. Individual infections, although they do not commonly result in more severe respiratory tract illness, are associated with substantial direct and indirect resource use. The product of frequency and burden for CFLIs is likely to be greater in magnitude than for any other respiratory syndrome, but further work is required to document this. Our understanding of the viral causes of CLFIs, although incomplete, has improved in recent years. Documenting burden is also an important step in progress towards improved control and management of these illnesses.


Respiratory Syncytial Virus Acute Otitis Medium Common Cold Respiratory Virus Invasive Pneumococcal Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Wat D (2004) The common cold:A review of the literature. Eur J Intern Med 15:79–88PubMedGoogle Scholar
  2. 2.
    Mäkelä MJ, Puhakka T, Ruuskanen O, Leinonen M, Saikku P, Kimpimäki M, Blomqvist S, Hyypiä T, Arstila P (1998) Viruses and bacteria in the etiology of the common cold. J Clin Microbiol 36:539–542PubMedGoogle Scholar
  3. 3.
    Arruda E, Pitkäranta A, Witek TJ, Doyle CA, Hayden FG (1997) Frequency and natural history of rhinovirus infections in adults during autumn. J Clin Microbiol 35:2864–2868PubMedGoogle Scholar
  4. 4.
    van den Hoogen BG, de Jong JC, Groen J, Kuiken T, de Groot R, Fouchier RAM, Osterhaus ADME (2001) A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med 7:19–24Google Scholar
  5. 5.
    van der Hoek L, Pyrc K, Jebbink MF, Vermeulen-Oost W, Berkhout RJM, Wolthers KC, Wertheim-van Dillen PME, Kaandorp J, Spaargaren J, Berkhout B (2004) Identification of a new human coronavirus. Nat Med 10:368–373PubMedGoogle Scholar
  6. 6.
    Woo PCY, Lau SKP, Chu C-M, Chan K-H, Tsoi H-W, Huang Y, Wong BHL, Poon RWS, Cai JJ, Luk W-K et al. (2005) Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia. J Virol 79:884–895PubMedGoogle Scholar
  7. 7.
    Allander T, Tammi MT, Eriksson M, Bjerkner A, Tiveljung-Lindell A, Andersson B (2005) Cloning of a human parvovirus by molecular screening of respiratory tract samples. Proc Nat Acad Sci USA 102:12891–12896PubMedGoogle Scholar
  8. 8.
    Arden KE, McErlean P, Nissen MD, Sloots TP, Mackay IM (2006) Frequent detection of human rhinoviruses, paramyxoviruses, coronaviruses, and bocavirus during acute respiratory tract infections. J Med Virol 78:1232–1240PubMedGoogle Scholar
  9. 9.
    Lamson D, Renwick N, Kapoor V, Liu Z, Palacios G, Ju J, Dean A, St GK, Briese T, Lipkin WI (2006) MassTag polymerase-chain-reaction detection of respiratory pathogens, including a new rhinovirus genotype, that caused influenza-like illness in New York State during 2004–2005. J Infect Dis 194:1398–1402PubMedGoogle Scholar
  10. 10.
    Lau SKP, Yip CCY, Tsoi H-W, Lee RA, So L-Y, Lau Y-L, Chan K-H, Woo PCY, Yuen K-Y (2007) Clinical features and complete genome characterization of a distinct human rhinovirus genetic cluster, probably representing a previously undetected HRV species, HRV-C, associated with acute respiratory illness in children. J Clin Microbiol 45:3655–3664PubMedGoogle Scholar
  11. 11.
    McErlean P, Shackleton LA, Andrewes E, Webster DR, Lambert SB, Nissen MD, Sloots TP, Mackay IM (2008) Distinguishing molecular features and clinical characteristics of a putative new rhinovirus species, human rhinovirus C (HRV C). P LoS One 3:e1847Google Scholar
  12. 12.
    Esposito S, Bosis S, Niesters HG, Tremolati E, Sabatini C, Porta A, Fossali E, Osterhaus AD, Principi N (2008) Impact of human bocavirus on children and their families. J Clin Microbiol 46:1337–1342PubMedGoogle Scholar
  13. 13.
    Illi S, von ME, Lau S, Bergmann R, Niggemann B, Sommerfeld C, Wahn U (2001) Early childhood infectious diseases and the development of asthma up to school age: A birth cohort study. BMJ 322:390–395PubMedGoogle Scholar
  14. 14.
    Hershenson MB, Johnston SL (2006) Rhinovirus infections: More than a common cold. Am J Respir Crit Care Med 174:1284–1285PubMedGoogle Scholar
  15. 15.
    Heikkinen T, Järvinen A (2003) The common cold. Lancet 361:51–59PubMedGoogle Scholar
  16. 16.
    Johnston SL, Sanderson G, Pattemore PK, Smith S, Bardin PG, Bruce CB, Lambden PR, Tyrrell DAJ, Holgate ST (1993) Use of polymerase chain reaction for diagnosis of picornavirus infection in subjects with and without respiratory symptoms. J Clin Microbiol 31:111–117PubMedGoogle Scholar
  17. 17.
    Turner RB (1998) The common cold. Pediatr Ann 27:790–795PubMedGoogle Scholar
  18. 18.
    Pappas DE, Hendley JO, Hayden FG, Winther B (2008) Symptom profile of common colds in school-aged children. Pediatr Infect Dis J 27:8–11PubMedGoogle Scholar
  19. 19.
    Eccles R (2007) Mechanisms of symptoms of the common cold and influenza. Br J Hosp Med 68:578–582Google Scholar
  20. 20.
    Pizzichini MMM, Pizzichini M, Efthimiadis A, Chauhan AJ, Johnston SL, Hussack P, Mahony J, Dolovich J, Hargreave FE (1998) Asthma and natural colds. Am J Respir Crit Care Med 158:1178–1184PubMedGoogle Scholar
  21. 21.
    Lemanske RF, Gern JE, Gangnon RE (2006) Viral specimen collection by parents increases response rate in population-based virus studies. J Allergy Clin Immunol 117:956–957Google Scholar
  22. 22.
    Phillips CA, Melnick JL, Grim CA (1968) Rhinovirus infections in a student population: Isolation of the five new serotypes. Am J Epidemiol 87:447–456PubMedGoogle Scholar
  23. 23.
    Minor TE, Dick EC, Peterson JA, Docherty DE (1974) Failure of naturally acquired rhinovirus infections to produce temporal immunity to heterologous serotypes. Infect Immun 10:1192–1193PubMedGoogle Scholar
  24. 24.
    Cooney MK, Kenny GE (1977) Demonstration of dual rhinovirus infect humans by isolation of different serotypes in human heteroploid (HeLa) and human diploid fibroblast cell cultures. J Clin Microbiol 5:202–207PubMedGoogle Scholar
  25. 25.
    Cooney MK, Hall CB, Fox JP (1972) The Seattle virus Watch. III. Evaluation of isolation methods and summary of infections detected by virus isolations. Am J Epidemiol 96: 286–305PubMedGoogle Scholar
  26. 26.
    Renwick N, Schweiger B, Kapoor V, Liu Z, Villari J, Bullmann R, Miething R, Briese T, Lipkin WI (2007) A recently identified rhinovirus genotype is associated with severe respiratory-tract infection in children in Germany. J Infect Dis 196: 1754–1760PubMedGoogle Scholar
  27. 27.
    Lee W-M, Kiesner C, Pappas T, Lee I, Grindle K, Jartti T, Jakiela B, Lemanske RF, Shult PA, Gern JE (2007) A diverse group of previously unrecognized human rhinoviruses are common causes of respiratory illness in infants. PLoS One 2: e966PubMedGoogle Scholar
  28. 28.
    Peltola V, Waris M, Österback R, Susi P, Ruuskanen O, Hyypiä T (2008) Rhinovirus transmission within families with children: Incidence of symptomatic and asymptomatic infections. J Infect Dis 197: 382–389PubMedGoogle Scholar
  29. 29.
    Yusuf S, Piedimonte G, Auais A, Demmler G, Krishnan S, van Caseele P, Singleton R, Broor S, Parveen S, Avendano L. et al. (2007) The relationship of meteorological conditions to the epidemic activity of respiratory syncytial virus. Epidemiol Infect 135: 1077–1090PubMedGoogle Scholar
  30. 30.
    Mackay IM Waliuzzaman Z, Chidlow GR, Fegredo DC, Laingam S, Adamson P, Harnett GB, Rawlinson W, Nissen MD, Sloots TP (2004) Use of the P gene to genotype human metapneumovirus identifies 4 viral subtypes. J Infect Dis 190: 1913–1918PubMedGoogle Scholar
  31. 31.
    Mackay IM, Bialasiewicz S, Jacob KC, McQueen E, Arden KE, Nissen MD, Sloots TP (2006) Genetic diversity of human metapneumovirus over 4 consecutive years in Australia. J Infect Dis 193:1630–1633PubMedGoogle Scholar
  32. 32.
    McErlean P, Shackleton LA, Lambert SB, Nissen MD, Sloots TP, Mackay IM (2007) Characterisation of a newly identified human rhinovirus, HRV-QPM, discovered in infants with bronchiolitis. J Clin Virol 39:67–75PubMedGoogle Scholar
  33. 33.
    Glezen WP, Paredes A, Taber LH (1980) Influenza in children relationship to other respiratory agents. JAMA 243:1345–1349PubMedGoogle Scholar
  34. 34.
    Chew FT, Doraisingham s, Ling AE, Kumarasinghe G, Lee BW (1998) Seasonal trends of viral respiratory tract infections in the tropics. Epidemiol Infect 121: 121–128PubMedGoogle Scholar
  35. 35.
    Jansen AG, Sanders EA, Van der Ende A, van Loon AM, Hoes AW, Hak E (2008) Invasive pneumococcal and meningococcal disease: Association with influenza virus and respiratory syncytial virus activity? Epidemiol Infect 136: 1448–1454PubMedGoogle Scholar
  36. 36.
    Johnson HE, Altman R, Hamre D, Ward T (1964) Viral infections and the common cold. Chest 45: 46–53Google Scholar
  37. 37.
    Al-Sunaidi M, Williams CH, Hughes PJ, Schnurr DP, Stanway G (2007) Analysis of a new human parechovirus allows the definition of parechovirus types and the identification of RNA structural domains. J Virol 81:1013–1021PubMedGoogle Scholar
  38. 38.
    Hamre D, Connelly AP, Procknow JJ (1966) Virologic studies of acute respiratory disease in young adults. IV. Virus isolations during four years of surveillance. Am J Epidemiol 83: 238–249PubMedGoogle Scholar
  39. 39.
    Johnston NW, Johnston SL, Norman GR, Dai J, Sears MR (2006) The September epidemic of asthma hospitalization: School children as disease vectors. J Allergy Clin Immunol 117:557–562PubMedGoogle Scholar
  40. 40.
    Deal EC Jr, McFadden ER Jr, Ingram RH Jr, Breslin FJ, Jaeger JJ (1980) Airway responsiveness to cold air and hyperpnea in normal subjects and in those with hay fever and asthma. Am Rev Respir Dis 121:621–628PubMedGoogle Scholar
  41. 41.
    Winther B, Hayden FG, Hendley JO (2006) Picornavirus infections in children diagnosed by RT-PCR during longitudinal surveillance with weekly sampling: Association with symptomatic illness and effect of season. J Med Virol 78: 644–650PubMedGoogle Scholar
  42. 42.
    Vesa S, Kleemola M, Blomqvist S, Takala A, Kilpi T, Hovi T (2001) Epidemiology of documented viral respiratory infections and acute otitis media in a cohort of children followed from two to twenty-four months of age. Pediatr Infect Dis J 20:574–581PubMedGoogle Scholar
  43. 43.
    Silva MJ, Ferraz C, Pissarra S, Cardoso MJ, Simões J, Vitór AB (2007) Role of viruses and atypical bacteria in asthma exacerbations among children in Oporto (Portugal). Allergol Immunopathol 35:4–9Google Scholar
  44. 44.
    Miller EK, Lu X, Erdman DD, Poehling KA, Zhu Y, Griffin MR, Hartvert TV, Anderson LJ, Weinberg GA, Hall CB et al. (2007) Rhinovirus-associated hospitalizations in young children. J Infect Dis 195:773–781PubMedGoogle Scholar
  45. 45.
    Gwaltney JM Jr, Hendley JO, Simon G, Jordan WS Jr (1966) Rhinovirus infections in an industrial population. I. The occurrence of illness. N Engl J Med 275: 1261–1268PubMedGoogle Scholar
  46. 46.
    Fox JP, Cooney MK, Hall CE (1975) The Seattle virus watch. V. Epidemiologic observation of rhinovirus infections, 1965-1969 in families with young children. Am J Epidemiol 101:122–143PubMedGoogle Scholar
  47. 47.
    Lambert SB, Allen KM, Druce JD, Birch CJ, Mackay IM, Carlin JB, Carapetis JP, Sloots TP, Nissen MD, Nolan TM (2007) Community epidemiology of human metapneumovirus, human coronavirus NL63, and other respiratory viruses in healthy preschool-aged children using parent-collected specimens. Pediatrics 120: e929–e937PubMedGoogle Scholar
  48. 48.
    Jartti T, Lehtinen P, Vuorinen T, Österback R, van den Hoogen B, Osterhaus ADME, Ruuskanen O (2004) Respiratory picornaviruses and respiratory syncytial virus as causative agents of acute expiratory wheezing in children. Emerg Infect Dis 10: 1095–1101PubMedGoogle Scholar
  49. 49.
    Wald TG, Shult P, Krause P, Miller BA, Drinka P, Gravenstein S (1995) A rhinovirus outbreak among residents of a long-term care facility. Ann Intern Med 123:588–593PubMedGoogle Scholar
  50. 50.
    Dick EC, Blumer CR, Evans AS (1967) Epidemiology of infections with rhinovirus types 43 and 55 in a group of university of Wisconsin student families. Am J Epidemiol 86:386–400PubMedGoogle Scholar
  51. 51.
    Hament JM, Kimpen JL, Fleer A, Wolfs TF (1999) Respiratory viral infection predisposing for bacterial disease: A concise review. FEMS Immunol Med Microbiol 26:189–195PubMedGoogle Scholar
  52. 52.
    Peltola VT, McCullers JA (2004) Respiratory viruses predisposing to bacterial infections: Role of neuraminidase. Pediatr Infect Dis J 23:S87–S97PubMedGoogle Scholar
  53. 53.
    Selinger DS, Reed WP, McLaren LC (1981) Model for studying bacterial adherence to epithelial cells infected with viruses. Infect Immun 32:941–944PubMedGoogle Scholar
  54. 54.
    McCullers JA, Bartmess KC (2003) Role of neuraminidase in lethal synergism between influenza virus and Streptococcus pneumoniae. J Infect Dis 187: 1000–1009PubMedGoogle Scholar
  55. 55.
    Okamoto S, Kawabata S, Nakagawa I, Okuno Y, Goto T, Sano K, Hamada S (2003) Influenza A virus-infected hosts boost an invasive type of Streptococcus pyogenes infection in mice. J Virol 77:4104–4112PubMedGoogle Scholar
  56. 56.
    Ishizuka S, Yamaya M, Suzuki T, Takahashi H, Ida S, Sasaki T, Inoue D, Sekizawa K, Nishimura H, Sasaki H (2003) Effects of rhinovirus infection on the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells. J Infect Dis 188:1928–1939PubMedGoogle Scholar
  57. 57.
    Oliver BG, Lim S, Wark P, Laza-Stanca V, King N, Black JL, Burgess JK, Roth M, Johnston SL (2008) Rhinovirus exposure impairs immune responses to bacterial products in human alveolar macrophages. Thorax 63:519–525PubMedGoogle Scholar
  58. 58.
    Watson M, Gilmour R, Menzies R, Ferson M, McIntyre P (2006) The association of respiratory viruses, temperature, and other climatic parameters with the incidence of invasive pneumococcal disease in Sydney, Australia. Clin Infect Dis 42:211–215PubMedGoogle Scholar
  59. 59.
    Murdoch DR, Jennings LC (2009) Association of respiratory virus activity and environmental factors with the incidence of invasive pneumococcal disease. J Infect 58:37–46PubMedGoogle Scholar
  60. 60.
    Madhi SA, Klugman KP (2004) A role for Streptococcus pneumoniae in virus-associated pneumonia. Nat Med 10:811–813PubMedGoogle Scholar
  61. 61.
    Kaiser L, Aubert J-D, Pache J-C, Deffernez C, Rochat T, Garbino J, Wunderli W, Meylan P, Yerly S, Perrin L et al. (2006) Chronic rhinoviral infection in lung transplant recipients. Am J Respir Crit Care Med 174:1392–1399PubMedGoogle Scholar
  62. 62.
    Larson HE, Reed SE, Tyrrell DAJ (1980) Isolation of rhinoviruses and coronaviruses from 38 colds in adults. J Med Virol 5:221–229PubMedGoogle Scholar
  63. 63.
    Denny FW, Clyde WA Jr (1986) Acute lower respiratory tract infections in nonhospitalized children. J Pediatr 108:635–646PubMedGoogle Scholar
  64. 64.
    Whelen AC, Persing DH (1996) The role of nucleic acid amplification and detection in the clinical microbiology laboratory. Annu Rev Microbiol 50: 349–373PubMedGoogle Scholar
  65. 65.
    Carman WF, Wallace LA, Walker J, McIntyre S, Noone A, Christie P, Millar J, Douglas JD (2000) Rapid virological surveillance of community influenza infection in general practice. Br Med J 321:736–737Google Scholar
  66. 66.
    Ogilvie M (2001) Molecular techniques should not now replace cell culture in diagnostic virology laboratories. Rev Med Virol 11:351–354PubMedGoogle Scholar
  67. 67.
    Leland DS, Ginocchio CC (2007) Role of cell culture for virus detection in the age of technology. Clin Microbiol Rev 20:49–78PubMedGoogle Scholar
  68. 68.
    Mahony JB (2008) Detection of respiratory viruses by molecular methods. Clin Microbiol Rev 21:716–747PubMedGoogle Scholar
  69. 69.
    Andrewes CH, Chaproniere DM, Gompels AEH, Pereira HG, Roden AT (1953) Propagation of common-cold virus in tissue cultures. Lancet 265: 546–547PubMedGoogle Scholar
  70. 70.
    Andrewes CH (1966) Rhinoviruses and common colds. Annu Rev Med 17: 361–370PubMedGoogle Scholar
  71. 71.
    Pelon W, Mogabgab WJ, Phillips LA, Pierce WE (1957) A cytopathogenic agent isolated from naval recruits with mild respiratory illnesses. Proc Soc Exp Biol Med 94:262–267PubMedGoogle Scholar
  72. 72.
    Price WH (1956) The isolation of a new virus associated with respiratory clinical disease in humans. Proc Natl Acad Sci USA 42:892–896PubMedGoogle Scholar
  73. 73.
    Olson LC, Willhight M, Buescher EL (1972) Recovery and characterization of non-cytopathogenic rhinoviruses. J Gen Virol 17:237–240PubMedGoogle Scholar
  74. 74.
    Douglas RG Jr, Cate TR, Gerone PJ, Couch RB (1966) Quantititative rhinovirus shedding patterns in volunteers. Am Rev Respir Dis 94:159–167PubMedGoogle Scholar
  75. 75.
    D’Alessio DJ, Meschievitz CK, Peterson JA, Dick CR, Dick EC (1984) Shortduration exposure and the transmission of rhinoviral colds. J Infect Dis 150: 189–194PubMedGoogle Scholar
  76. 76.
    Cate TR, Couch RB, Fleet WF, Griffith WR, Gerone PJ, Knight V (1965) Production of tracheobronchitis in volunteers with rhinovirus in a small-particle aerosol. Am J Epidemiol 81:95–105PubMedGoogle Scholar
  77. 77.
    Hendley JO, Wenzel RP, Gwaltney JM Jr (1973) Transmission of rhinovirus colds by self-inoculation. N Engl J Med 288:1361–1364PubMedGoogle Scholar
  78. 78.
    Sethi SK (1978) Reproducible plaquing system for rhinovirus serotypes in HeLa cells — Agarose suspension. Acta Virol 22:60–65PubMedGoogle Scholar
  79. 79.
    Gwaltney JM Jr (1966) Micro-neutralization test for identification of rhinovirus serotypes. Proc Soc Exp Biol Med 122:1137–1141PubMedGoogle Scholar
  80. 80.
    Behbehani AM, Lee LH (1964) Growth, plaque production and cationic stabilization of rhinovirus type 1 (Echovirus 28). J Bacteriol 88: 1680–1611Google Scholar
  81. 81.
    Fiala M, Kenny GE (1966) Enhancement of rhinovirus plaque formation in human heteroploid cell cultures by magnesium and calcium. J Bacteriol 92: 1717–1715Google Scholar
  82. 82.
    Parsons R, Tyrrell DAJ (1961) A plaque method for assaying some viruses isolated from common colds. Nature 189:640–642PubMedGoogle Scholar
  83. 83.
    Papadopoulos NG, Sanderson G, Hunter J, Johnston SL (1999) Rhinoviruses replicated effectively at lower airway temperatures. J Med Virol 58:100–104PubMedGoogle Scholar
  84. 84.
    Rosenbaum MJ, De Berry P, Sullivan EJ, Pierce WE, Mueller RE, Peckinpaugh RO (1971) Epidemilogy of the common cold in military recruits with emphasis on infections by rhinovirus types 1A, 2, and two unclassified rhinoviruses. Am J Epidemiol 93:183–193PubMedGoogle Scholar
  85. 85.
    Mogabgab WJ, Pelon W (1957) Problems in characterizing and identifying an apparently new virus found in association with mild respiratory disease in recruits. Ann N Y Acad Sci 67:403–412PubMedGoogle Scholar
  86. 86.
    Hendley JO, Edmondson WP Jr, Gwaltney JM Jr (1972) Relation between naturally acquired immunity and infectivity of two rhinoviruses in volunteers. J Infect Dis 125:243–248PubMedGoogle Scholar
  87. 87.
    Relman DA (2003) Shedding light on microbial detection. N Engl J Med 349: 2162–2163PubMedGoogle Scholar
  88. 88.
    Kuypers J, Wright N, Ferrenberg J, Huang M-L, Cent A, Corey L, Morrow R (2006) Comparison of real-time PCR assays with fluorescent-antibody assays for diagnosis of respiratory virus infections in children. J Clin Microbiol 44: 2382–2388PubMedGoogle Scholar
  89. 89.
    Falsey AR, Walsh EE (2006) Viral pneumonia in older adults. Clin Infect Dis 42Google Scholar
  90. 90.
    Johnston SL, Bardin PG, Pattemore PK (1993) Viruses as precipitants of asthma symptoms. III. Rhinoviruses: Molecular biology and prospects for future intervention. Clin Exp Allergy 23:237–246PubMedGoogle Scholar
  91. 91.
    Ketler A, Hamparian VV, Hilleman MR (1962) Characterization and classification of ECHO 28-rhinovirus-coryzavirus agents. Proc Soc Exp Biol Med 110: 821–831PubMedGoogle Scholar
  92. 92.
    Conant RM, Hamparian VV (1968) Rhinoviruses: Basis for a numbering system. II. Serologic characterization of prototype strains. J Immunol 100: 107–113PubMedGoogle Scholar
  93. 93.
    Gwaltney JM Jr, Hendley JO (1978) Rhinovirus transmission: One if by air, two if by hand. Am J Epidemiol 107:357–361PubMedGoogle Scholar
  94. 94.
    Ledford RM, Patel NR, Demenczuk TM, Watanyar A, Herbertz T, Collett MS, Pevear DC (2004) VP1 sequencing of all human rhinovirus serotypes: Insights into genus phylogeny and susceptibility to antiviral capsid-binding compounds. J Virol 78:3663–3674PubMedGoogle Scholar
  95. 95.
    Oberste MS, Maher K, Kilpatrick DR, Pallansch LA (1999) Molecular evolution of the human enteroviruses: Correlation of serotype with VP1 sequence and application to picornavirus classification. J Virol 73:1941–1948PubMedGoogle Scholar
  96. 96.
    van de Pol AC, van Loon AM, Wolfs TF, Jansen NJ, Nijhuis M, Breteler EK, Schuurman R, Rossen JW (2007) Increased detection of respiratory syncytial virus, influenza viruses, parainfluenza viruses, and adenoviruses with real-time PCR in samples from patients with respiratory symptoms. J Clin Microbiol 45: 2260–2262PubMedGoogle Scholar
  97. 97.
    Pitkäranta A, Arruda E, Malmberg H, Hayden FG (1997) Detection of rhinovirus in sinus brushings of patients with acute community-acquired sinusitis by reverse transcription-PCR. J Clin Microbiol 35:1791–1793PubMedGoogle Scholar
  98. 98.
    Kämmerer U, Kunkel B, Korn K (1994) Nested PCR for specific detectio nand rapid identification of human picornaviruses. J Clin Microbiol 32:285–291PubMedGoogle Scholar
  99. 99.
    Andeweg AC, Bestebroer TM, Huybreghs M, Kimman TG, de Jong JC (1999) Improved detection of rhinoviruses in clinical samples by using a newly developed nested reverse transcription-PCR assay. J Clin Microbiol 37:524–530PubMedGoogle Scholar
  100. 100.
    Aberle JH, Aberle SW, Pracher E, Hutter H-P, Kundi M, Popw-Kraupp T (2005) Impact on clinical course of disease and interferon-γ response. Pediatr Infect Dis J 24:605–610PubMedGoogle Scholar
  101. 101.
    Versteegh FGA, Weverling GJ, Peeters MF, Wilbrink B, Veenstra-van Schie MTM, van Leewen-Gerritsen JM, Mooi-Kokenberg EANM, Schellekens JFP, Roord JJ (2005) Community-acquired pathogens associated with prolonged coughing in children: A prospective cohort study. Clin Microbiol Infect 11: 801–807PubMedGoogle Scholar
  102. 102.
    Hutchinson AF, Ghimire AK, Thompson MA, Black JF, Brand CA, Lowe AJ, Smallwood DM, Vlahos R, Bozinovski S, Brown GV et al. (2007) A community-based, ty-based, time-matched, case-control study of respiratory viruses and exacerbations of COPD. Respir Med 101: 2472–2481PubMedGoogle Scholar
  103. 103.
    Arruda E, Hayden FG (1993) Detection of human rhinovirus RNA in nasal washings by PCR. Mol Cell Probe 7: 373–379Google Scholar
  104. 104.
    Lu X, Holloway B, Dare RK, Kuypers J, Yagi S, Williams JV, Hall CB, Erdman DD (2008) Real-time reverse transcription-PCR assay for comprehensive detection of human rhinoviruses. J Clin Microbiol 46: 533–539PubMedGoogle Scholar
  105. 105.
    Suvilehto J, Roivainen M, Seppänen M, Meri S, Hovi T, Carpén O, Pitkäranta A (2006) Rhinovirus/enterovirus RNA in tonsillar tissue of children with tonsillar disease. J Clin Virol 35: 292–297PubMedGoogle Scholar
  106. 106.
    Mackay IM, Bustin S, Andrade JM, Nissen MD, Sloots TP (2007) Quantification of microorganimsms: Not human, not dimple, not quick. In: IM Mackay (ed): Real-time PCR in microbiology. Caister Academic Press, Norfolk, 133–182Google Scholar
  107. 107.
    Stensballe LG, Trautner S, Kofoed PE, Nante E, Hedegaard K, Jensen IP, Aaby P (2002) Comparison of nasopharyngeal aspirate and nasal swab specimens for detection of respiratory syncytial virus in different settings in a developing country. Trop Med Int Health 7: 317–321PubMedGoogle Scholar
  108. 108.
    Macfarlane P, Denham J, Assous J, Hughes C (2005) RSV testing in bronchiolitis: Which nasal sampling method is best? Arch Dis Child 90: 634–635PubMedGoogle Scholar
  109. 109.
    Lambert SB, Whiley DM, O’Neill NT, Andrews EC, Canavan FM, Bletchly C, Siebert DJ, Sloots TP, Nissen MD (2008) Comparing nose-throat swabs and nasopharyngeal aspirates collected from children with symptoms for respiratory virus identification using real-time polymerase chain reaction. Pediatrics 122: e615–e620PubMedGoogle Scholar
  110. 110.
    Lambert SB, Allen KM, Nolan TM (2008) Parent-collected respiratory specimens — A novel method for respiratory virus and vaccine efficacy research. Vaccine 26: 1826–1831PubMedGoogle Scholar
  111. 111.
    Brunstein JD, Cline CL, McKinney S, Thomas E (2008) Evidence from multiplex molecular assays for complex multipathogen interactions in acute respiratory infections. J Clin Microbiol 46: 97–102PubMedGoogle Scholar
  112. 112.
    Stott EJ, Eadie MB, Grist NR (1969) Rhinovirus infections of children in hospital: Isolation of three possibly new rhinovirus serotypes. Am J Epidemiol 90: 45–52PubMedGoogle Scholar
  113. 113.
    Tiveljung-Lindell A, Rotzen-Ostlund M, Gupta S, Ullstrand R, Grillner L, Zweygberg-Wirgart B, Allander T (2009) Development and implementation of a molecular diagnostic platform for daily rapid detection of 15 respiratory viruses. J Med Virol 81: 167–175PubMedGoogle Scholar
  114. 114.
    Richard N, Komurian-Pradel F, Javouhey E, Perret M, Rajoharison A, Bagnaud A, Billaud G, Vernet G, Lina B, Floret D et al. (2008) The impact of dual viral infection in infants admitted to a pediatric intensive care unit associated with severe bronchiolitis. Pediatr Infect Dis J 27: 1–5Google Scholar
  115. 115.
    Gunson RN, Collins TC, Carman WF (2005) Real-time RT-PCR detection of 12 respiratory viral infections in four triplex reactions. J Clin Virol 33: 341–344PubMedGoogle Scholar
  116. 116.
    Nolte FS, Marshall DJ, Rasberry C, Schievelbein S, Banks GG, Storch GA, Arens MQ, Buller RS, Prudent JR (2007) MultiCode-PLx system for multiplexed detection of seventeen respiratory viruses. J Clin Microbiol 45: 2779–2786PubMedGoogle Scholar
  117. 117.
    Mahony J, Chong S, Merante F, Yaghoubian S, Sinha T, Lisle C, Janeczko R (2007) Development of a respiratory virus panel test for detection of twenty human respiratory viruses by use of multiplex PCR and a fluid microbead-based assay. J Clin Microbiol 45: 2965–2970PubMedGoogle Scholar
  118. 118.
    Drews SJ, Blair J, Lombos E, DeLima C, Burton L, Mazzulli T, Low DE (2008) Use of the Seeplex RV Detection kit for surveillance of respiratory viral out-breaks in Toronto, Ontario, Canada. Ann Clin Lab Sci 38: 376–379PubMedGoogle Scholar
  119. 119.
    Yoo SJ, Kuak EY, Shin BM (2007) Detection of 12 respiratory viruses with two-set multiplex reverse transcriptase-PCR assay using a dual priming oligonucleotide system. Korean J Lab Med 27: 420–427PubMedGoogle Scholar
  120. 120.
    Roh KH, Kim J, Nam MH, Yoon S, Lee CK, Lee K, Yoo Y, Kim MJ, Cho Y (2008) Comparison of the Seeplex reverse transcription PCR assay with the R-mix viral culture and immunofluorescence techniques for detection of eight respiratory viruses. Ann Clin Lab Sci 38: 41–46PubMedGoogle Scholar
  121. 121.
    Han J, Swan DC, Smith SJ, Lum SH, Sefers SE, Unger ER, Tang YW (2006) Simultaneous amplification and identification of 25 human papillomavirus types with Templex technology. J Clin Microbiol 44: 4157–4162PubMedGoogle Scholar
  122. 122.
    Brunstein J, Thomas E (2006) Direct screening of clinical specimens for multiple respiratory pathogens using the Genaco Respiratory Panels 1 and 2. Diagn Mol Pathol 15: 169–173PubMedGoogle Scholar
  123. 123.
    Li H, McCormac MA, Estes RW, Sefers SE, Dare RK, Chappell JD, Erdman DD, Wright PF, Tang Y-W (2007) Simultaneous detection and high-throughput identification of a panel of RNA viruses causing respiratory tract infections. J Clin Microbiol 45: 2105–2109PubMedGoogle Scholar
  124. 124.
    Briese T, Palacios G, Kokoris M, Jabado O, Liu Z, Renwick N, Kapoor V, Casas I, Pozo F, Limberger R et al. (2005) Diagnostic system for rapid and sensitive differential detection of pathogens. Emerg Infect Dis 11: 310–313PubMedGoogle Scholar
  125. 125.
    Dominguez SR, Briese T, Palacios G, Hui J, Villari J, Kapoor V, Tokarz R, Glode MP, Anderson MS, Robinson CC et al. (2008) Multiplex MassTag-PCR for respiratory pathogens in pediatric nasopharyngeal washes negative by conventional diagnostic testing shows a high prevalence of viruses belonging to a newly recognized rhinovirus clade. J Clin Virol 43: 219–222PubMedGoogle Scholar
  126. 126.
    Wang D, Coscoy L, Zylberberg M, Avila PC, Boushey HA, Ganem D, DeRisi JL (2002) Microarray-based detection and genotyping of viral pathogens. Proc Natl Acad Sci USA 99: 15687–15692PubMedGoogle Scholar
  127. 127.
    Ostroff R, Ettinger A, La H, Rihanek M, Zalman L, Meador III J, Patick AK, Worland S, Polisky B (2001) Rapid multiserotype detection of human rhinoviruses on optically coated silicon surfaces. J Clin Virol 21: 105–117PubMedGoogle Scholar
  128. 128.
    Shanmukh S, Jones L, Driskell J, Zhao Y, Dluhy R, Tripp RA (2006) Rapid and sensitive detection of respiratory virus molecular signatures using a silver nanorod array SERS substrate. Nano Lett 6: 2630–2636PubMedGoogle Scholar
  129. 129.
    Bae HG, Nitsche A, Teichmann A, Biel SS, Niedrig M (2003) Detection of yellow fever virus: A comparison of quantitative real-time PCR and plaque assay. J Virol Methods 110: 185–191PubMedGoogle Scholar
  130. 130.
    Jartti T, Lee W-M, Pappas T, Evans M, Lemanske RF, Gern JE (2008) Serial viral infections in infants with recurrent respiratory illnesses. Eur Respir J 32: 314–320PubMedGoogle Scholar
  131. 131.
    Mackay IM, Arden KE, Nissen MD, Sloots TP (2007) Challenges facing real-time PCR characterization of acute respiratory tract infections. In: IM Mackay (ed): Real-Time PCR in Microbiology: From Diagnosis to Characterization. Caister Academic Press, Norfolk, 269–318Google Scholar
  132. 132.
    Brouard J, Freymuth F, Vabret A, Jokic M, Guillois B, Duhamel JF (2000) Viral co-infections in immunocompetent infants with bronchiolitis: Prospective epidemiologic study (in French). Arch Pediatr 7 (Suppl 3): 531s–535sPubMedGoogle Scholar
  133. 133.
    Papadopoulos NG, Moustaki M, Tsolia M, Bossios A, Astra E, Prezerakou A, Gourgiotis D, Kafetzis D (2002) Association of rhinovirus infection with increased disease severity in acute bronchiolitis. Am J Respir Crit Care Med 165: 1285–1289PubMedGoogle Scholar
  134. 134.
    Maggi F, Pifferi M, Vatteroni M, Fornai C, Tempestini E, Anzilotti S, Lanini L, Andreoli E, Ragazzo V, Pistello M et al. (2003) Human metapneumovirus associated with respiratory tract infections in a 3-year study of nasal swabs from infants in Italy. J Clin Microbiol 41: 2987–2991PubMedGoogle Scholar
  135. 135.
    Peltola J, Waris M, Hyypiä T, Ruuskanen O (2006) Respiratory viruses in children with invasive pneumococcal disease. Clin Infect Dis 43: 266–268PubMedGoogle Scholar
  136. 136.
    Juvén T, Mertsola J, Waris M, Leinonen M, Meurman O, Roivainen M, Eskola J, Saikku P, Ruuskanen O (2000) Etiology of community-acquired pneumonia in 254 hospitalized children. Pediatr Infect Dis J 19: 293–298PubMedGoogle Scholar
  137. 137.
    Garcia-Garcia ML, Calvo C, Perez-Brena P, De Cea JM, Acosta B, Casas I (2006) Prevalence and clinical characteristics of human metapneumovirus infections in hospitalized infants in Spain. Pediatr Pulmonol 41: 863–871PubMedGoogle Scholar
  138. 138.
    van der Zalm MM, van Ewijk BE, Wilbrink B, Uiterwaal CSPM, Wolfs TFW, van der Ent CK (2009) Respiratory pathogens in children with and without respiratory symptoms. J Pediatr 154: 396–400PubMedGoogle Scholar
  139. 139.
    Aberle JH, Aberle SW, Pracher E, Hutter H-P, Kundi M, Popw-Kraupp T (2005) Single versus dual respiratory virus infections in hospitalized infants: Impact on clinical course of disease and interferon-gamma response. Pediatr Infect Dis J 24: 605–610PubMedGoogle Scholar
  140. 140.
    Greensill J, McNamara PS, Dove W, Flanagan B, Smyth RL, Hart CA (2003) Human metapneumovirus in severe respiratory syncytial virus bronchiolitis. Emerg Infect Dis 9: 372–375PubMedGoogle Scholar
  141. 141.
    Simon A, Wilkesmann A, Muller A, Schildgen O (2007) HMPV infections are frequently accompanied by co-infections. Pediatr Pulmonol 42: 98PubMedGoogle Scholar
  142. 142.
    Mackay IM (2007) Human bocavirus: Multisystem detection raises questions about infection. I Infect Dis 196: 968–970Google Scholar
  143. 143.
    Winther B, Alper CM, Mandel EM, Doyle WJ, Hendley JO (2007) Temporal relationships between colds, upper respiratory viruses detected by polymerase chain reaction, and otitis media in young children followed through a typical cold season. Pediatrics 119: 1069–1075PubMedGoogle Scholar
  144. 144.
    Alper CM, Doyle WJ, Winther B, Hendley JO (2008) Upper respiratory virus detection without parent-reported illness in children is virus-specific. J Clin Virol 43: 120–122PubMedGoogle Scholar
  145. 145.
    Glezen WP, Denny FW (1973) Epidemiology of acute lower respiratory disease in children. N Engl J Med 288: 498–505PubMedCrossRefGoogle Scholar
  146. 146.
    Hitchcock G, Tyrrell DA (1960) Some virus isolations from common colds.II. Virus interference in tissue cultures. Lancet 1: 237–239PubMedGoogle Scholar
  147. 147.
    Mizgerd JP (2006) Lung infection-a public health priority. PloS Medicine 3: e76PubMedGoogle Scholar
  148. 148.
    Bardin PG, Johnston SL, Pattemore PK (1992) Viruses as precipitants of asthma symptoms. II. Physiology and mechanisms. Clin Exp Allergy 22: 809–822PubMedGoogle Scholar
  149. 149.
    Kusel MMH, de Klerk NH, Holt PG, Kebadze T, Johnston SL, Sly PD (2006) Role of respiratory viruses in acute upper and lower respiratory tract illness in the first year of life. Pediatr Infect Dis J 25: 680–686PubMedGoogle Scholar
  150. 150.
    Hakonarson H, Maskeri N, Carter C, Hodinka RL, Campbell D, Grunstein MM (1998) Mechanism of rhinovirus-induced changes in airway smooth muscle responsiveness. J Clin Invest 102: 1732–1741PubMedGoogle Scholar
  151. 151.
    Gern JE, Galagan DM, Jarjour NN, Dick EC, Busse WW (2008) Detection of rhinovirus RNA in lower airway cells during experimentally induced infection. Am J Respir Crit Care Med 155: 1159–1161Google Scholar
  152. 152.
    Jakiela B, Brockman-Schneider R, Amineva S, Lee W-M, Gern JE (2008) Basal cells of differentiated bronchial epithelium are more susceptible to rhinovirus infection. Am J Respir Cell Mol Biol 38: 517–523PubMedGoogle Scholar
  153. 153.
    Gern JE, Busse WW (2002) Relationship of viral infections to wheezing illnesses and asthma. Nat Rev Immunol 2: 132–138PubMedGoogle Scholar
  154. 154.
    Martin JG, Siddiqui S, Hassan M (2006) Immune responses to viral infections: Relevance for asthma. Paediatr Respir Rev 7S: S125–S127Google Scholar
  155. 155.
    Krilov L, Pierik L, Keller E, Mahan K, Watson D, Hirsch M, Hamparian V, McIntosh K (1986) The association of rhinoviruses with lower respiratory tract disease in hospitalized patients. J Med Virol 19: 345–352PubMedGoogle Scholar
  156. 156.
    Monto AS, Bryan ER, Ohmit S (1987) Rhinovirus infections in Tecumseh, Michigan: Frequency of illness and number of serotypes. J Infect Dis 156: 43–49PubMedGoogle Scholar
  157. 157.
    El-Sahly HM, Atmar RL, Glezen WP, Greenberg SB (2000) Spectrum of clinical illness in hospitalized patients with “Common cold” virus infections. Clin Infect Dis 31: 96–100PubMedGoogle Scholar
  158. 158.
    Glezen WP, Loda FA, Clyde WA, Senior RJ, Sheaffer CI, Conley WG, Denny FW (1971) Epidemiologic patterns of acute lower respiratory disease of children in a pediatric group practice. J Pediatr 78: 397–406PubMedGoogle Scholar
  159. 159.
    Bloom HH, Forsyth BR, Johnson KM, Chanock RM (1963) Relationship of rhinovirus infection to mild upper respiratory disease. JAMA 186: 38–45PubMedGoogle Scholar
  160. 160.
    Collinson J, Nicholson KG, Cancio E, Ashman J, Ireland DC, Hammersley V, Kent J, O’Callaghan C (1996) Effects of upper respiratory tract infections in patients with cystic fibrosis. Thorax 51: 1115–1122PubMedGoogle Scholar
  161. 161.
    Andréoletti L, Lesay M, Deschildre A, Lambert V, Dewilde A, Wattré P (2000) Differential detection of rhinoviruses and enteroviruses RNA sequences associated with classical immunofluorescence assay detection of respiratory virus antigens in nasopharyngeal swabs from infants with bronchiolitis. J Med Virol 61: 341–346PubMedGoogle Scholar
  162. 162.
    Rakes GP, Arruda E, Ingram JM, Hoover GE, Zambrano JC, Hayden FG, Platts-Mills TAE, Heymann PW (1999) Rhinovirus and respiratory syncytial virus in wheezing children requiring emergency care. Am J Respir Crit Care Med 159: 785–790PubMedGoogle Scholar
  163. 163.
    Henderson FW, Clyde WA, Collier AM, Denny FW, Senior RJ, Sheaffer CI, Conley WG, Christian RM (1979) The etiologic and epidemiologic spectrum of bronchiolitis in pediatric practice. J Pediatr 95: 183–190PubMedGoogle Scholar
  164. 164.
    Martinez FD (2007) Gene-environment interactions in asthma. Proc Am Thorac Soc 4: 26–31PubMedGoogle Scholar
  165. 165.
    Mallia P, Johnston SL (2006) How viral infections cause exacerbation of airway diseases. Chest 130: 1203–1210PubMedGoogle Scholar
  166. 166.
    Pattemore PK, Johnston SL, Bardin PG (1992) Viruses as precipitants of asthma symptoms. I. Epidemiology. Clin Exp Allergy 22: 325–336PubMedGoogle Scholar
  167. 167.
    Heymann PW, Platts-Mills TAE, Johnston SL (2005) Role of viral infections, atopy and antiviral immunity in the etiology of wheezing exacerbations among children and young adults. Pediatr Infect Dis J 24: S217–S222PubMedGoogle Scholar
  168. 168.
    Lidwell OM, Sommerville T (1951) Observations on the incidence and distribution of the common cold in a rural community during 1948 and 1949. J Hyg (Lond) 49: 365–381Google Scholar
  169. 169.
    Green RM, Custovic A, Sanderson G, Hunter J, Johnston SL, Woodcock A (2007) Synergism between allergens and viruses and risk of hospital admission with asthma: Case-control study. Br Med J 324: 1–5Google Scholar
  170. 170.
    Johnston SL, Pattemore PK, Sanderson G, Smith S, Lampe F, Josephs L, Symington P, O’Toole S, Myint SH, Tyrrell DAJ et al. (1995) Community study of role of viral infections in exacerbations of asthma in 9–11 year old children. Br Med J 310: 1225–1229Google Scholar
  171. 171.
    Minor TE, Dick EC, DeMeo AN, Ouellette JJ, Cohen M, Reed CE (1974) Viruses as precipitants of asthmatic attacks in children. JAMA 227: 292–298PubMedGoogle Scholar
  172. 172.
    Roldaan AC, Masural N (1982) Viral respiratory infections in asthmatic children staying in a mountain resort. Eur J Respir Dis 63: 140–150PubMedGoogle Scholar
  173. 173.
    Lemanske RF (2002) The childhood origins of asthma (COAST) study. Pediatr Allergy Immunol 15: 1–6Google Scholar
  174. 174.
    van der Zalm MM, Uiterwaal CSPM, de Jong BM, Wilbrink B, van der Ent CK (2006) Viral specimen collection by parents increases response rate in population-based virus studies. J Allergy Clin Immunol 117: 955–957PubMedGoogle Scholar
  175. 175.
    Lemanske RF, Jackson DJ, Gangnon RE, Evans MD, Li Z, Shult PA, Kirk CJ, Reisdorf E, Roberg KA, Anderson EL et al. (2005) Rhinovirus illnesses during infancy predict subsequent childhood wheezing. J Allergy Clin Immunol 116: 571–577PubMedGoogle Scholar
  176. 176.
    Minor TE, Baker JW, Dick EC, DeMeo AN, Ouellette JJ, Cohen M, Reed CE (1974) Greater frequency of viral; respiratory infections in asthmatic children as compared with their nonasthmatic siblings. J Pediatr 85: 472–477PubMedGoogle Scholar
  177. 177.
    Nicholson KG, Kent J, Ireland DC (1993) Respiratory viruses and exacerbations of asthma in adults. Br Med J 307: 982–986Google Scholar
  178. 178.
    Rawlinson WD, Waliuzzaman Z, Carter IW, Belessis YC, Gilbert KM, Morton JR (2003) Asthma exacerbations in children are associated with rhinovirus but not human metapneumovirus infection. J Infect Dis 187: 1314–1318PubMedGoogle Scholar
  179. 179.
    Yoo J, Tcheurekdjian H, Lynch SV, Cabana M, Boushey HA (2007) Microbial manipulation of immune function for asthma prevention. Inferences from clinical trials. Proc Am Thorac Soc 4:277–282PubMedGoogle Scholar
  180. 180.
    Fedson DS, Nichol KL (2006) Influenza vaccination: Policy versus evidence: No gap between policy and evidence. BMJ 333:1020PubMedGoogle Scholar
  181. 181.
    Drummond M, Sculpher M, Torrance G (2005) Methods for the economic evaluation of health care programmes. Oxford University Press: OxfordGoogle Scholar
  182. 182.
    Michaud CM, Murray CJ, Bloom BR (2001) Burden of disease—implications for future research. JAMA 285:535–539PubMedGoogle Scholar
  183. 183.
    Monto AS (2002) Epidemiology of viral respiratory infections. Am J Med 112:4S–12SPubMedGoogle Scholar
  184. 184.
    Revai K, Dobbs LA, Nair S (2007) Incidence of acute otitis media and sinusitis complicating upper respiratory tract infection: The effect of age. Pediatrics 119: e1408–1412PubMedGoogle Scholar
  185. 185.
    Bridges-Webb C, Britt H, Miles DA, Neary S, Charles J, Traynor V (1993) Morbidity and treatment in general practice in Australia. Aust Fram Physician 22:336-339–342-346Google Scholar
  186. 186.
    Fedrick AM, Monto AS, Nightengale B (2003) The economic burden of noninfluenza-related viral respiratory tract infection in the United States. Arch Intern Med 163:487–494Google Scholar
  187. 187.
    Bertino JS (2002) Cost burden of viral respiratory infections: Issues for formulary decision makers. Am J Med 112:42S–49SPubMedGoogle Scholar
  188. 188.
    Molinari NA, Ortega-Sanchez IR, Messonnier ML (2007) The annual impact of seasonal influenza in the US: Measuring disease burden and costs. Vaccine 25: 5086–5096PubMedGoogle Scholar
  189. 189.
    O’Shea TM, Sevick MA, Givner LB (1998) Costs and benefits of respiratory syncytial virus immunoglobulin to prevent hospitalization for lower respiratory tract illness in very low birth weight infants. Pediatr Infect Dis J 17:587–593PubMedGoogle Scholar
  190. 190.
    Numa A (200) Outcome of respiratory syncytial virus infection and a costbenefit analysis of prophylaxis. J Paediatr Child Health 36:422–427Google Scholar
  191. 191.
    Rietveld E, DeJonge HC, Polder JJ (2004) Anticipated costs of hospitalization for respiratory syncytial virus infection in young children at risk. Pediatr Infect Dis J 23:523–529PubMedGoogle Scholar
  192. 192.
    Paramore LC, Ciuryla V, Ciesla G (2004) Economic impact of respiratory syncytial virus-related illness in the US: An analysis of national databases. Pharmacoeconomics 22:275–284PubMedGoogle Scholar
  193. 193.
    Lambert S, O’Grady K-A, Gabriel S, Carter R, Nolan T (2004) The cost of seasonal respiratory illnesses in Australian children: The dominance of patient and family costs and implications for vaccine use. Commun Dis Intell 28:510–516PubMedGoogle Scholar
  194. 194.
    Lambert SB, Allen KM, Druce JD (2005) Respiratory illness during winter: A cohort study of urban children from temperate Australia. J Paediatr Child Health 41:125–129PubMedGoogle Scholar
  195. 195.
    Lambert SB, Allen KM, Carter RC, Nolan TM (2008) The cost of communitymanaged viral respiratory illnesses in a cohort of healthy preschool-aged children. Respir Res 9:1–11Google Scholar
  196. 196.
    Australian Bureau of Statistics (2007) Australian Bureau of Statistics: Australian Economic Indicators: May 2004Google Scholar
  197. 197.
    Turner J, Tran T, Birch C (2004) Higher than normal seasonal influenza activity in Victoria, 2003. Commun Dis Intell 28:175–180PubMedGoogle Scholar
  198. 198.
    Hollinghurst S, Gorst C, Fahey T (2008) Measuring the financial burden of acute cough in pre-school children: A cost of illness study. BMC Fam Pract 9: 10PubMedGoogle Scholar
  199. 199.
    Coleman MS, Washington ML, Orenstein WA (2006) Interdisciplinary epidemiologic and economic research needed to support a universal childhood influenza vaccination policy. Epidemiol Rev 28:41–46PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag Basel/Switzerland 2009

Authors and Affiliations

  • Ian M. Mackay
    • 1
    • 2
  • Katherine E. Arden
    • 1
    • 2
  • Stephen B. Lambert
    • 1
    • 2
  1. 1.Queensland Paediatric Infectious Diseases Laboratory, Sir Albert Sakzewski Virus Research Centre, Queensland Children’s Medical Research InstituteRoyal Children’s HospitalBrisbaneAustralia
  2. 2.Clinical Medical Virology CentreUniversity of QueenslandBrisbaneAustralia

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