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The genes behind rheumatology

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Microarrays in Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Chronic inflammation is the central pathophysiology in rheumatic diseases. Blood contains most types of immune cells involved in this inflammation. Investigation of purified cell types has various advantages but also technical limitations compared to whole blood. Infiltration of immune cells into involved organs is a leading phenomenon and molecular processes in the inflamed tissue seem to change and increase by number and intensity compared to those in the blood. Many genes found differentially expressed in tissues are elevated as part of the infiltration, while only a smaller fraction becomes regulated upon inflammation. Gene products as biomarkers, which are affected by disease-specific pathomechanisms or by treatment, are of diagnostic importance. With the growing number of different biologics, markers indicative of different pathomechanisms are important for predicting drug responsiveness and treatment stratification. Finally, a comparison of pathological signatures between different types of diseases will contribute to identifying both similarities and differences in molecular processes and thus may provide insight into the driving mechanisms and etiology of rheumatic diseases.

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Author information

Authors and Affiliations

  1. Department of Rheumatology and Clinical Immunology, Charité-University Medicine, Berlin, Germany

    Thomas Häupl, Bruno Stuhlmüller, Karl Skriner & Gerd Burmester

  2. German Arthritis Research Center (DRFZ), Berlin, Germany

    Andreas Grützkau & Andreas Radbruch

Authors
  1. Thomas Häupl
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  2. Andreas Grützkau
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  3. Bruno Stuhlmüller
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  4. Karl Skriner
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  5. Gerd Burmester
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  6. Andreas Radbruch
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Editor information

Editors and Affiliations

  1. Research & Development, Miltenyi Biotec GmbH, Friedrich-Ebert-Straße 68, 51429 Bergisch, Gladbach, Germany

    Andreas Bosio

  2. Miltenyi Biotec GmbH, Friedrich-Ebert-Straße 68, 51429 Bergisch, Gladbach, Germany

    Bernhard Gerstmayer

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© 2008 Birkhäuser Verlag Basel/Switzerland

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Häupl, T., Grützkau, A., Stuhlmüller, B., Skriner, K., Burmester, G., Radbruch, A. (2008). The genes behind rheumatology. In: Bosio, A., Gerstmayer, B. (eds) Microarrays in Inflammation. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8334-3_13

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