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The genes behind rheumatology

  • Thomas Häupl
  • Andreas Grützkau
  • Bruno Stuhlmüller
  • Karl Skriner
  • Gerd Burmester
  • Andreas Radbruch
Part of the Progress in Inflammation Research book series (PIR)

Abstract

Chronic inflammation is the central pathophysiology in rheumatic diseases. Blood contains most types of immune cells involved in this inflammation. Investigation of purified cell types has various advantages but also technical limitations compared to whole blood. Infiltration of immune cells into involved organs is a leading phenomenon and molecular processes in the inflamed tissue seem to change and increase by number and intensity compared to those in the blood. Many genes found differentially expressed in tissues are elevated as part of the infiltration, while only a smaller fraction becomes regulated upon inflammation. Gene products as biomarkers, which are affected by disease-specific pathomechanisms or by treatment, are of diagnostic importance. With the growing number of different biologics, markers indicative of different pathomechanisms are important for predicting drug responsiveness and treatment stratification. Finally, a comparison of pathological signatures between different types of diseases will contribute to identifying both similarities and differences in molecular processes and thus may provide insight into the driving mechanisms and etiology of rheumatic diseases.

Keywords

Rheumatoid Arthritis Immune Cell Rheumatic Disease Synovial Tissue Molecular Process 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2008

Authors and Affiliations

  • Thomas Häupl
    • 1
  • Andreas Grützkau
    • 2
  • Bruno Stuhlmüller
    • 1
  • Karl Skriner
    • 1
  • Gerd Burmester
    • 1
  • Andreas Radbruch
    • 2
  1. 1.Department of Rheumatology and Clinical ImmunologyCharité-University MedicineBerlinGermany
  2. 2.German Arthritis Research Center (DRFZ)BerlinGermany

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