Abstract
The ability of immune cells to recognise foreign pathogens, while simultaneously maintaining tolerance towards proteins produced by the body’s own cells, forms the basis of mammalian immunity. At the heart of the immune system are the lymphocytes, which orchestrate the adaptive immune response through clonal expansion upon recognition of a specific antigen. The plasticity of the immune system allows exquisite control of the body’s defences. However, the adaptive immune system can also be directed towards host proteins (‘self antigens’). The reasons for this failure in immunity are varied, and include a genetic basis or evasion of the host immune response by viruses. Nevertheless, the consequences — autoimmune diseases such as rheumatoid arthritis (RA) — are frequently associated with inflammation, immune cell dysfunction and changes in the vasculature.
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Paleolog, E., Akhavani, M.A. (2008). The lymphocyte in inflammatory angiogenesis. In: Seed, M.P., Walsh, D.A. (eds) Angiogenesis in Inflammation: Mechanisms and Clinical Correlates. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-7650-5_4
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DOI: https://doi.org/10.1007/978-3-7643-7650-5_4
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