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Novel lipid mediators in resolution and their aspirin triggered epimers: Lipoxins, resolvins, and protectins

  • Chapter
The Resolution of Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

In The Doctor’s Dilemma (1906) by the popular writer George Bernard Shaw, the character Sir Bloomfield Bonnington stated:

Drugs can only repress symptoms: they cannot eradicate disease. The true remedy for all diseases is Nature’s remedy. Nature and Science are at one, Sir Patrick, believe me; though you were taught differently. Nature has provided, in the white corpuscles as you call them — in the phagocytes as we call them — a natural means of devouring and destroying all disease germs. There is at bottom only one genuinely scientific treatment for all diseases, and that is to stimulate the phagocytes. Stimulate the phagocytes. In view of our current appreciation of resolution of inflammation, reviewed in this chapter, these lines from The Doctor’s Dilemma take on new meaning, namely, resolution as an active biochemical and cellular process in controlled molecular terms by specialised mediators that function in resolution and can give rise to new approaches to therapeutics. Efforts taken in the author’s laboratory focus on gaining a molecular understanding of the natural means by which the body controls phagocytes, both positive and negative physiological signals. In this context, the eicosanoids generated from arachidonic acid are mediators of special interest, given their prominent and well-appreciated role(s) as pro-inflammatory mediators [1]. Our interest in endogenous control mechanisms in inflammation led us to recognise the lipoxins (LXs) as the first local mediators possessing both anti-inflammatory and pro-resolving actions (recently reviewed in [2]).

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  1. Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA

    Charles N. Serhan

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  1. MRC Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, 47 Little France Crescent Edinburgh, EH16 4TJ, Scotland, UK

    Adriano G. Rossi  & Deborah A. Sawatzky  & 

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Serhan, C.N. (2008). Novel lipid mediators in resolution and their aspirin triggered epimers: Lipoxins, resolvins, and protectins. In: Rossi, A.G., Sawatzky, D.A. (eds) The Resolution of Inflammation. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-7506-5_6

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