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Innate immune mechanisms in the resolution of inflammation

  • Chapter
The Resolution of Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

The inflammatory response is a highly orchestrated and tightly controlled mechanism of defence characterised by infiltration of granulocytes and mononuclear cells. For this response to be beneficial it must deal with its initial inflammatory stimulus and then subside to allow the tissue to return to its pre-inflamed state. Such resolution requires cessation of inflammatory cell recruitment and, importantly, deletion of recruited cells in a safe and controlled fashion. Failure to delete cells appropriately may permit effete cells to undergo necrosis (lysis due to loss of plasma membrane integrity) with the generation of inflammatory and autoimmune consequences associated with leakage of intracellular contents [1].

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Authors and Affiliations

  1. School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK

    Andrew Devitt

  2. MRC Centre for Inflammation Research, The Queen’s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK

    Christopher D. Gregory

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  1. MRC Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, 47 Little France Crescent Edinburgh, EH16 4TJ, Scotland, UK

    Adriano G. Rossi  & Deborah A. Sawatzky  & 

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Devitt, A., Gregory, C.D. (2008). Innate immune mechanisms in the resolution of inflammation. In: Rossi, A.G., Sawatzky, D.A. (eds) The Resolution of Inflammation. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-7506-5_3

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