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Innate immune mechanisms in the resolution of inflammation

  • Andrew Devitt
  • Christopher D. Gregory
Part of the Progress in Inflammation Research book series (PIR)

Abstract

The inflammatory response is a highly orchestrated and tightly controlled mechanism of defence characterised by infiltration of granulocytes and mononuclear cells. For this response to be beneficial it must deal with its initial inflammatory stimulus and then subside to allow the tissue to return to its pre-inflamed state. Such resolution requires cessation of inflammatory cell recruitment and, importantly, deletion of recruited cells in a safe and controlled fashion. Failure to delete cells appropriately may permit effete cells to undergo necrosis (lysis due to loss of plasma membrane integrity) with the generation of inflammatory and autoimmune consequences associated with leakage of intracellular contents [1].

Keywords

Apoptotic Cell Innate Immune System Scavenger Receptor Apoptotic Neutrophil Innate Immune Mechanism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2008

Authors and Affiliations

  • Andrew Devitt
    • 1
  • Christopher D. Gregory
    • 2
  1. 1.School of Life and Health SciencesAston UniversityAston Triangle, BirminghamUK
  2. 2.MRC Centre for Inflammation ResearchThe Queen’s Medical Research InstituteEdinburghUK

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