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Granulocyte apoptosis

  • Chapter
The Resolution of Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Neutrophil apoptosis (programmed cell death) is now recognised to play a fundamental role in the physiological resolution of innate immune responses. Early work by Metchnikoff correlated the ingestion of microphages (neutrophils) by macrophages with the resolution of acute inflammation, but nearly 100 years elapsed before the key role of apoptosis in determining the lifespan of granulocytes and their clearance from sites of inflammation was described [1]. Further work showed that apoptosis leads to down-regulation of neutrophil pro-inflammatory functions [2] and this, together with evidence that macrophage clearance of apoptotic granulocytes was anti-inflammatory [3], suggested that apoptosis induction could be a powerful therapeutic strategy to “turn off” neutrophilic inflammation [2].

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Authors and Affiliations

  1. Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK

    Moira K. B. Whyte

  2. MRC Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh Medical School, Edinburgh, EH16 4TJ, UK

    Christopher Haslett

  3. Respiratory Medicine Division, Department of Medicine, University of Cambridge, School of Clinical Medicine, Addenbrooke’s and Papworth Hospitals, Cambridge, CB2 2QQ, UK

    Edwin R. Chilvers

Authors
  1. Moira K. B. Whyte
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  2. Christopher Haslett
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  3. Edwin R. Chilvers
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Editors and Affiliations

  1. MRC Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, 47 Little France Crescent Edinburgh, EH16 4TJ, Scotland, UK

    Adriano G. Rossi  & Deborah A. Sawatzky  & 

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Whyte, M.K.B., Haslett, C., Chilvers, E.R. (2008). Granulocyte apoptosis. In: Rossi, A.G., Sawatzky, D.A. (eds) The Resolution of Inflammation. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-7506-5_2

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