Immunobiology of tumor infiltrating lymphocytes (TIL) in germinomas
Histologically germinoma is characterized by lobular nests of large pale neoplastic cells with a large round nucleus, interspersed to a variable degree with small lymphoid cells. Noncaseating granulomatous inflammation with multinucleated giant cells also accompanies some germinomas . The amount of inflammation varies from case to case and in some instances overshadows the neoplastic infiltrates. Common histological features of the germinoma are shared with gonadal seminomas, dysgerminomas, and extragonadal seminomas. In contrast, other central nervous system (CNS) germ cell tumors (GCTs) such as teratomas, yolk sac tumors, and embryonal carcinomas, lack the abundant tumor infiltrating lymphocytes (TIL).
KeywordsMajor Histocompatibility Complex Major Histocompatibility Complex Class Stem Cell Factor Tumor Infiltrate Lymphocyte Testicular Seminoma
Unable to display preview. Download preview PDF.
- 9.Russell DS, Rubinstein LJ (1989) Germinomas. In: Russel PS, Rubinstein LJ (eds) Pathology of tumours of the nervous system. Edward Arnold, London, pp 668–676Google Scholar
- 13.Totterman TH, Parthenais E, Hayry P, Timonen T, Saksela E (1980) Cytological and functional analysis of inflammatory infiltrates in human malignant tumors. III. Further functional investigations using cultures, autochthonous tumor cell lines and freeze-thawed infiltrating inflammatory cells. Cell Immunol 55: 219–222PubMedCrossRefGoogle Scholar