Immunobiology of tumor infiltrating lymphocytes (TIL) in germinomas

  • M. Tada
  • Y. Sawamura


Histologically germinoma is characterized by lobular nests of large pale neoplastic cells with a large round nucleus, interspersed to a variable degree with small lymphoid cells. Noncaseating granulomatous inflammation with multinucleated giant cells also accompanies some germinomas [1]. The amount of inflammation varies from case to case and in some instances overshadows the neoplastic infiltrates. Common histological features of the germinoma are shared with gonadal seminomas, dysgerminomas, and extragonadal seminomas. In contrast, other central nervous system (CNS) germ cell tumors (GCTs) such as teratomas, yolk sac tumors, and embryonal carcinomas, lack the abundant tumor infiltrating lymphocytes (TIL).


Major Histocompatibility Complex Major Histocompatibility Complex Class Stem Cell Factor Tumor Infiltrate Lymphocyte Testicular Seminoma 
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© Springer-Verlag/Wien 1998

Authors and Affiliations

  • M. Tada
    • 1
  • Y. Sawamura
    • 1
  1. 1.Department of NeurosurgeryHokkaido University School of MedicineSapporoJapan

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