Intracranial Germ Cell Tumors

1. Front Matter

   Pages I-XIV

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2. Introduction

   • N. de Tribolet

   Pages 1-1

3. WHO histological classification of tumors of the central nervous system: germ cell tumors (WHO, 1993)

   • Yutaka Sawamura

   Pages 3-4

4. Epidemiology of CNS GCTs

   • M. Tada

   Pages 5-16

5. Pathology

   • K. Meagher-Villemure

   Pages 17-37

6. Immunobiology of tumor infiltrating lymphocytes (TIL) in germinomas

   • M. Tada, Y. Sawamura

   Pages 37-43

7. Genesis and genetics of intracranial germ cell tumors

   • E. G. Van Meir, J. W. Oosterhuis, L. H. J. Looijenga

   Pages 45-76

8. Clinical findings and diagnosis

   • S. Kikuchi, Y. Sawamura, K. Tashiro, S. Terae, K. Fujieda, K. Yoshida et al.

   Pages 77-153

9. Prognosis of CNS GCTs

   • Y. Sawamura

   Pages 155-168

10. Overview for management

    • Y. Sawamura, H. Shirato

    Pages 169-191

11. Surgical management

    • Y. Sawamura, N. de Tribolet, J. Régis, O. Chinot, P. Bouillot, H. Dufour et al.

    Pages 193-233

12. Chemotherapy for CNS GCTs

    • C. Balmaceda, S. Modak, J. Finlay

    Pages 243-281

13. Radiotherapy for CNS GCTs

    • H. Shirato

    Pages 283-315

14. Adverse effect of therapy and late sequelae in survivors

    • H. Shirato, Y. Sawamura, M. Tada, R. Brauner, L. Adan, J.-C. Souberbielle et al.

    Pages 317-369

15. Back Matter

    Pages 371-374

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Intracranial germ cell tumors are a group of uncommon neoplasms of the central nervous system. The clinical features and natural history of these lesions are quite unique and variable. While intracranial germ cell tumors have been a fascination to neurooncologists for decades, the relatively small number of patients seen in any single institution has hampered the important clinical investigation that is so needed. This text is complete with detailed information concerning the epidemiology, pathology, oncological biology, clinical findings, radiology, and treatment options including surgical strategy, radiotherapy, and chemotherapy for this heterogeneous group of neoplasms. The ongoing clinical trials concerning the optimization of therapy are efficiently summarized. An important final segment addresses the late sequelae of therapy which is of great significance since the majority suffering from these tumors are young patients. This first and only book on intracranial germ cell tumors includes excellent and comprehensive data sheets, illustrations, and radiograms. It provides a detailed and outstanding reference source for physicians taking care of patients with intracranial germ cell tumors, and will be a very welcome edition to their reference libraries.

• Nervous System
• Tumor
• biopsy
• carcinoma
• cell
• central nervous system
• chemotherapy
• classification
• clinical trial
• diagnosis
• genetics
• lymphocytes
• pathology
• radiology
• radiotherapy
• Radiaton Oncology

"... a comprehensive, well-organized book dealing with the epidemiology, pathology, diagnosis and treatment of intracranial germ cell tumors. The contributing authors generally succeed in communicating both the broad outlines and the detail of the various aspects covered.” Child's Nervous System 2000, vol.16/nr.9 "...an indispensable textbook for all those who care for patients with CNS germ cell tumors.” Acta Neurologica Belgica 12/1999

• Department of Neurosurgery, Hokkaido University School of Medicine, Sapporo, Japan

  Yutaka Sawamura

• Department of Radiology, Hokkaido University School of Medicine, Sapporo, Japan

  Hiroki Shirato

• Service de Neurochirurgie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

  Nicolas Tribolet

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