Zusammenfassung
Kaum ein anderes Enzym ist so gründlich untersucht worden wie die Glukose-6Phosphat-Dehydrogenase (G-6-PD). Dies beruht einerseits auf der großen biologischen Verbreitung und der biochemischen Schlüsselfunktion des Enzyms. Andererseits wurden die genetische Variabilität und die klinische Bedeutung des Enzyms intensiv erforscht. Da die Prävalenz des Enzymmangels auch in Deutschland relativ hoch ist (0,14-0,37%, in einigen Ländern des Mittelmeergebietes, Afrikas und Asiens: 3,0-30,0% und darüber) und eine Vielzahl hämolyseinduzierender Medikamente häufig zurAnwendung kommen, ist eine hohe Aktualität in der medizinischen Versorgung gegeben. Die Bedeutung des G-6-PD-Mangels liegt somit in der sehr hohen Häufigkeit, kombiniert mit vielen z.T. lebensbedrohlichen Noxen. Diese Noxen sind überwiegend aus der modernen Medizin in Ländern mit Hochtechnologic entstanden. Eine Risikominimierung für die Patienten ist Gegenstand des allgemeinen Trends in unserer Gesellschaft hin zu einem hohen medizinischen Standard.
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Solem, E. (2001). Glukose-6-Phosphat-Dehydrogenase-Mangel. In: Screening auf angeborene endokrine und metabole Störungen. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6252-1_36
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