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Tumour Hypoxia and the Hypoxia-Inducible Transcription Factors: Key Players in Cancer Progression and Metastasis

  • Chapter
Tumor Cell Metabolism

Abstract

Solid tumours often display regions of low oxygenation, hypoxia. Tumour hypoxia is linked to cancer progression and poor patient outcome. The hypoxia-inducible transcription factors HIF1 and HIF2 are the main mediators of the hypoxic response inducing metabolic adaptation, survival signals and angiogenesis. Hypoxia and HIF signalling further contribute to malignant progression by promoting a cancer stem cell phenotype and epithelial-to-mesenchymal transition. HIF signalling thus links the intra-tumour microenvironment to cancer cell behaviour and disease development. Hypoxia and HIF signalling are largely confined to the tumour making them appealing therapy targets. However, the partially diverging roles of HIF1 and HIF2 and the various responses to hypoxia in different cells and settings pose challenges. This chapter will cover hypoxia and HIF signalling in relation to tumour progression and cross-links with some dominant signalling pathways in cancer including Notch and Wnt/beta-catenin.

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Acknowledgements

There is a vast amount of literature in this research area making it impossible to include all important publications. I have in many cases therefore referred to review articles and in other cases, I am sure, missed out on interesting work. My work is financed by the Swedish Research Council, the Crafoord Foundation, Percy Falk Foundation, the Royal Physiographic Society, Hans v Kantzow foundation, Gunnar Nilsson CS, CREATE Health and BioCare.

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  1. Translational Cancer Research, Lund University, Medicon Village Bldg 404, 223 81, Lund, Sweden

    Annika Jögi

  2. Department of Laboratory Medicine Lund, Lund University Cancer Center at Medicon Village, Lund University, Lund, Sweden

    Annika Jögi

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Correspondence to Annika Jögi .

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  1. Inst. of Veterinary Physiology and Bioch, Justus-Liebig-University of Giessen, Gießen, Hessen, Germany

    Sybille Mazurek

  2. Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

    Maria Shoshan

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Jögi, A. (2015). Tumour Hypoxia and the Hypoxia-Inducible Transcription Factors: Key Players in Cancer Progression and Metastasis. In: Mazurek, S., Shoshan, M. (eds) Tumor Cell Metabolism. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1824-5_4

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