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Tumor Cell Metabolism

Pathways, Regulation and Biology

  • Book
  • © 2015

Overview

Editors:
  1. Sybille Mazurek

    1. Inst. of Veterinary Physiology and Bioch, Justus-Liebig-University of Giessen, Gießen, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. Maria Shoshan

    1. Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Gives a clear overview of novel aspects in tumor cell metabolism

  • Maps and explains signaling pathways of tumor metabolome biology

  • Written by international experts

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-viii
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  2. On the Roles of Altered Tumor Cell Metabolism in Tumor Biology

    1. Front Matter

      Pages 1-1
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    2. Metabolic Remodeling in Bioenergetic Disorders and Cancer

      • Emilie Obre, Rodrigue Rossignol
      Pages 3-22

    3. Tumor Cell Complexity and Metabolic Flexibility in Tumorigenesis and Metastasis

      • Michael V. Berridge, Patries M. Herst
      Pages 23-43

    4. Autophagy and Tumor Cell Metabolism

      • Ahmed Hamaï, Joelle Botti, Maryam Mehrpour, Patrice Codogno
      Pages 45-63

    5. Tumour Hypoxia and the Hypoxia-Inducible Transcription Factors: Key Players in Cancer Progression and Metastasis

      • Annika Jögi
      Pages 65-98

  3. Some Specific Regulators of Cellular Metabolism in Normal and Cancer Cells

    1. Front Matter

      Pages 99-99
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    2. MYC Regulation of Metabolism and Cancer

      • Arvin M. Gouw, Annie L. Hsieh, Zachary E. Stine, Chi V. Dang
      Pages 101-122

    3. Pyruvate Kinase M2: A Metabolic Tuner

      • Vibhor Gupta, Mohd Askandar Iqbal, Bhupender Kumar, Rameshwar N. K. Bamezai
      Pages 123-142

    4. Role of the Pentose Phosphate Pathway in Tumour Metabolism

      • Adrián Benito, Santiago Diaz-Moralli, Johannes F. Coy, Josep J. Centelles, Marta Cascante
      Pages 143-163

    5. Enzymes of the Tumour Metabolome in Diagnostic Applications

      • Philip D. Hardt
      Pages 165-171

    6. Contribution of pH Alterations to the Tumor Microenvironment

      • Angela Strambi, Angelo De Milito
      Pages 173-196

  4. On the Role of Mitochondria in Tumor Metabolism

    1. Front Matter

      Pages 197-197
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    2. Mitochondrial Mutations in Cancer Progression: Causative, Bystanders, or Modifiers of Tumorigenesis?

      • Ivana Kurelac, Michele Vidone, Giulia Girolimetti, Claudia Calabrese, Giuseppe Gasparre
      Pages 199-231

    3. The Relevance of the Mitochondrial H+-ATP Synthase in Cancer Biology

      • Inmaculada Martínez-Reyes, José M. Cuezva
      Pages 233-256

    4. Canceromics Studies Unravel Tumor’s Glutamine Addiction After Metabolic Reprogramming

      • Javier Márquez, José M. Matés, Francisco J. Alonso, Mercedes Martín-Rufián, Carolina Lobo, José A. Campos-Sandoval
      Pages 257-286

    5. Essential Role of Mitochondria in Pyrimidine Metabolism

      • Monika Löffler, Elizabeth A. Carrey, Elke Zameitat
      Pages 287-311

  5. On the New Omics of Metabolism

    1. Front Matter

      Pages 313-313
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    2. Metabolic Fluxes in Cancer Metabolism

      • Ulrich L. Günther, Mei G. Chong, Tatiana Volpari, Katarzyna M. Koczula, Karen Atkins, Christopher M. Bunce et al.
      Pages 315-348

    3. Targeted 13C-Labeled Tracer Fate Associations for Drug Efficacy Testing in Cancer

      • László G. Boros, Richard D. Beger, Emmanuelle J. Meuillet, Jerry R. Colca, Sándor Szalma, Patricia A. Thompson et al.
      Pages 349-372
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Keywords

About this book

The four sections of this book cover cell and molecular biology of tumor metabolism, metabolites, tumor microenvironment, diagnostics and epigenetics. Written by international experts, it provides a thorough insight into and understanding of tumor cell metabolism and its role in tumor biology. The book is intended for scientists in cancer cell and molecular biology, scientists in drug and diagnostic development, as well as for clinicians and oncologists.

Editors and Affiliations

  • Inst. of Veterinary Physiology and Bioch, Justus-Liebig-University of Giessen, Gießen, Germany

    Sybille Mazurek

  • Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

    Maria Shoshan

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