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JAK/STAT Signaling and Invertebrate Immune Responses

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Jak-Stat Signaling : From Basics to Disease

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Abstract

This review focuses on JAK/STAT signaling and its role in response to infection in invertebrates. Most of our knowledge comes from studies conducted in the model organism Drosophila melanogaster. However, we tentatively cover available information on JAK/STAT signaling in other invertebrates, including mosquitoes. Covered topics include the components of JAK/STAT signaling and their role in humoral, cellular and mucosal immunity. Finally, we summarize recent developments on the role of JAK/STAT signaling in the maintenance of homeostasis in response to intestinal challenge.

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Acknowledgments

We would like to thank Shaeri Mukherjee for her generous help in drawing the figures.

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  1. Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT, 06519, USA

    Feng Zhou & Hervé Agaisse

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  1. Feng Zhou
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  2. Hervé Agaisse
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Correspondence to Hervé Agaisse .

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  1. , Max F. Perutz Laboratories, University of Vienna, Dr. Bohr-Gasse 9/4, Vienna, 1030, Austria

    Thomas Decker

  2. , Animal Breeding and Genetics, University of Vienna, Veterinärplatz 1, Vienna, 1210, Austria

    Mathias Müller

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Zhou, F., Agaisse, H. (2012). JAK/STAT Signaling and Invertebrate Immune Responses. In: Decker, T., Müller, M. (eds) Jak-Stat Signaling : From Basics to Disease. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0891-8_9

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