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Jak-Stat Signaling : From Basics to Disease

  • Thomas Decker
  • Mathias Müller

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Thomas Decker, Mathias Müller
    Pages 1-4
  3. Claude Haan, Daniela Ungureanu, Tuija Pekkala, Olli Silvennoinen, Serge Haan
    Pages 5-25
  4. Mark A. Dawson, Andrew J. Bannister
    Pages 27-46
  5. Mathias Droescher, Uwe Vinkemeier
    Pages 47-63
  6. Amanda M. Jamieson, Matthias Farlik, Thomas Decker
    Pages 65-89
  7. Daniel J. Gough, Pravin Sehgal, David E. Levy
    Pages 91-98
  8. Claus Vogl, Priyank Shukla, Ingo Ebersberger
    Pages 99-114
  9. Kriti Gaur, Willis X. Li
    Pages 115-131
  10. Feng Zhou, Hervé Agaisse
    Pages 133-151
  11. Harini Nivarthi, Katrin Friedbichler, Richard Moriggl
    Pages 153-167
  12. Haiyan S. Li, Stephanie S. Watowich
    Pages 169-186
  13. Eva Maria Putz, Eva Zebedin, Veronika Sexl
    Pages 187-204
  14. Alejandro Villarino, Xiang-Ping Yang, Kiyoshi Hirahara, Yuka Kanno, John J. O’ Shea, Arian Laurence
    Pages 205-237
  15. Damla Olcaydu, Robert Kralovics
    Pages 239-258
  16. Jeffrey W. Schmidt, Kay-Uwe Wagner
    Pages 259-288
  17. Paulina Rampetsreiter, Robert Eferl
    Pages 289-304
  18. Lidia Avalle, Gabriella Regis, Valeria Poli
    Pages 305-333
  19. Maria M. Caffarel, Christine J. Watson
    Pages 335-351
  20. Lionel B. Ivashkiv
    Pages 353-370
  21. Birgit Strobl, Nicole R. Leitner, Mathias Müller
    Pages 387-423
  22. Ali Abdul-Sater, Christian Schindler
    Pages 425-441
  23. Back Matter
    Pages 443-448

About this book

Introduction

JAK tyrosine kinases and STAT transcription factors constitute a signaling pathway, which is activated by cytokines. By activating gene transcription it regulates essential biological responses to environmental cues. The Jak-Stat pathway is involved in the regulation of cell development, differentiation, proliferation and apoptosis. Improper function may contribute to hematopoietic malignancies and cancer. This book provides comprehensive insights into the latest basic and clinical developments in the field. The first part reviews recent findings and new technologies pertaining to basics of Jak-Stat function. The second part describes the evolution of Jak-Stat signaling and the role of the pathway in invertebrate organisms. The third part focuses on Jak-Stat signaling in hematopoietic cells under both physiological and pathophysiological conditions. Finally, chapters in the fourth section describe the relationship of Jak-Stat signaling to various states of disease, particularly infection, leukemias and solid cancers. The book is intended for all scientists in molecular biology, biochemistry and cell biology dealing with biomedical issues.

Keywords

Cell Differentiation Hematopoiesis Organ Development Transcription Factor Tyrosine kinase

Editors and affiliations

  • Thomas Decker
    • 1
  • Mathias Müller
    • 2
  1. 1., Max F. Perutz LaboratoriesUniversity of ViennaViennaAustria
  2. 2., Animal Breeding and GeneticsUniversity of ViennaViennaAustria

Bibliographic information

Industry Sectors
Pharma
Biotechnology