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STAT Transcription Factors: Controlling All Aspects of NK Cell Biology

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Jak-Stat Signaling : From Basics to Disease

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Abstract

Besides B and T cells, Natural Killer (NK) cells constitute the third lymphocytic population with a broad spectrum of skills and functions. For several decades NK cells have been portrayed as first line defense against virally infected and malignant cells. But recent reports unraveled far more diverse properties of NK cells, e.g. their involvement in reproductive immunology and in mucosal defense of pathogens in the gut, and especially their ability to retain memory over several months. This chapter combines well established paradigms of NK cell biology with recent findings and special emphasis on the JAK/STAT signaling pathway. NK cell development, activation and cytotoxic function are tightly regulated by a plethora of cytokines – prominent inducers of the JAK/STAT signaling cascade. The availability and detailed analysis of gene-targeted mice underscores the importance of STATs controlling all aspects of NK cell biology.

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Authors and Affiliations

  1. University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210, Vienna, Austria

    Eva Maria Putz & Veronika Sexl

  2. Medical University of Vienna, Waehringerstrasse 13a, 1090, Vienna, Austria

    Eva Zebedin

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  1. Eva Maria Putz
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  2. Eva Zebedin
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  3. Veronika Sexl
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Correspondence to Veronika Sexl .

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  1. , Max F. Perutz Laboratories, University of Vienna, Dr. Bohr-Gasse 9/4, Vienna, 1030, Austria

    Thomas Decker

  2. , Animal Breeding and Genetics, University of Vienna, Veterinärplatz 1, Vienna, 1210, Austria

    Mathias Müller

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Putz, E.M., Zebedin, E., Sexl, V. (2012). STAT Transcription Factors: Controlling All Aspects of NK Cell Biology. In: Decker, T., Müller, M. (eds) Jak-Stat Signaling : From Basics to Disease. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0891-8_12

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