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Metabolism of Human Diseases

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Abstract

Ingestion of a meal stimulates the physiological response to control the digestion, absorption, and assimilation of nutrients. The pancreas is integral to this process, communicating with other organs through hormones and metabolites to efficiently obtain and use energy sources [1]. Following the intake of food, the exocrine compartment (made up of acinar, duct, and centroacinar cells; Fig. 1) releases digestive fluid to facilitate the intestinal breakdown and absorption of nutrients [2]. In contrast, pancreatic endocrine cells (α-, β-, δ-, and pancreatic polypeptide cells) release hormones [3] that control how cells use and store energy fuels (i.e., glucose, lipids, and proteins) during different metabolic transitions (i.e., feeding, fasting, and exercise) [4].

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Author information

Authors and Affiliations

  1. Department of Medicine, UCSF Diabetes Center, 513 Parnassus Avenue, HSW 1116, 0540, San Francisco, CA, 94143, USA

    Alexandra E. Folias & Matthias Hebrok

Authors
  1. Alexandra E. Folias
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  2. Matthias Hebrok
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Corresponding author

Correspondence to Matthias Hebrok .

Editor information

Editors and Affiliations

  1. Institute of Metabolic Physiology, German Diabetes Center, Heinrich Heine University Düsseldorf, Düsseldorf, Germany

    Eckhard Lammert

  2. CardioMetabolic Diseases Research, Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany

    Martin Zeeb

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© 2014 Springer-Verlag Wien

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Folias, A.E., Hebrok, M. (2014). Overview. In: Lammert, E., Zeeb, M. (eds) Metabolism of Human Diseases. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0715-7_25

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