Skip to main content
SpringerLink
Log in

Osteoarthritis

  • Chapter
  • First Online:
Metabolism of Human Diseases

  • 171k Accesses

Abstract

Osteoarthritis (OA), the most common form of arthritis, is characterized by degradation and loss of articular cartilage, hypertrophic bone changes with osteophyte formation, subchondral bone remodeling, and inflammation of the synovial membrane. This disease can be triggered by external factors (e.g. trauma) and endogenous predisposing factors (e.g. age, genetics, high body mass index). It results in pain, and disability necessitating joint replacement at end-stage disease. Important advances have been made in understanding its pathological processes and promising disease-modifying OA drugs (DMOADs) are being developed that will slow the progression of the disease and improve current symptomatic treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Lawrence RC, Felson DT, Helmick CG, Arnold LM, Choi H, Deyo RA, Gabriel S, Hirsch R, Hochberg MC, Hunder GG, Jordan JM, Katz JN, Kremers HM, Wolfe F (2008) Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum 58:26–35

    Article  PubMed  PubMed Central  Google Scholar 

  2. Martel-Pelletier J, Lajeunesse D, Pelletier JP (2005) Etiopathogenesis of osteoarthritis. In: Koopman WJ, Moreland LW (eds) Arthritis & allied conditions a textbook of rheumatology, 15th edn. Lippincott, Williams & Wilkins, Baltimore, pp 2199–2226

    Google Scholar 

  3. Martel-Pelletier J, Boileau C, Pelletier JP, Roughley P (2008) Cartilage in normal and osteoarthritis conditions. In: Pap T (ed) Best practice & research clinical rheumatology, vol 22. Rapid Medical Media, East Sussex, pp 351–384

    Google Scholar 

  4. Martel-Pelletier J, Lajeunesse D, Pelletier JP (2007) Subchondral bone and osteoarthritis progression: a very significant role. In: Buckwalter JA, Lotz M, Stoltz JF (eds) Osteoarthritis, inflammation and degradation: a continuum, 1st edn. IOS Press, Amsterdam, pp 206–218

    Google Scholar 

  5. Martel-Pelletier J, Pelletier JP (2010) Is osteoarthritis a disease involving only cartilage or other articular tissues? Eklem Hastalik Cerrahisi 21:2–14

    PubMed  Google Scholar 

  6. Zhang W, Moskowitz RW, Nuki G, Abramson S, Altman RD, Arden N, Bierma-Zeinstra S, Brandt KD, Croft P, Doherty M, Dougados M, Hochberg M, Hunter DJ, Kwoh K, Lohmander LS, Tugwell P (2008) OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage 16:137–162

    Article  CAS  PubMed  Google Scholar 

  7. Hochberg MC, Altman RD, April KT, Benkhalti M, Guyatt G, McGowan J, Towheed T, Welch V, Wells G, Tugwell P (2012) American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res (Hoboken) 64:455–474

    Article  Google Scholar 

  8. Hochberg MC, Wohlreich M, Gaynor P, Hanna S, Risser R (2012) Clinically relevant outcomes based on analysis of pooled data from 2 trials of duloxetine in patients with knee osteoarthritis. J Rheumatol 39:352–358

    Article  CAS  PubMed  Google Scholar 

  9. Skljarevski V, Zhang S, Iyengar S, D’Souza D, Alaka K, Chappell A, Wernicke J (2011) Efficacy of duloxetine in patients with chronic pain conditions. Curr Drug Ther 6:296–303

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Trelle S, Reichenbach S, Wandel S, Hildebrand P, Tschannen B, Villiger PM, Egger M, Juni P (2011) Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis. BMJ 342:c7086

    Article  PubMed  PubMed Central  Google Scholar 

  11. Underwood M, Ashby D, Cross P, Hennessy E, Letley L, Martin J, Mt-Isa S, Parsons S, Vickers M, Whyte K (2008) Advice to use topical or oral ibuprofen for chronic knee pain in older people: randomised controlled trial and patient preference study. BMJ 336:138–142

    Article  CAS  PubMed  Google Scholar 

  12. Bellamy N, Campbell J, Robinson V, Gee T, Bourne R, Wells G (2005) Viscosupplementation for the treatment of osteoarthritis of the knee. Cochrane Database Syst Rev (2):CD005321

    Google Scholar 

  13. Lee YH, Woo JH, Choi SJ, Ji JD, Song GG (2010) Effect of glucosamine or chondroitin sulfate on the osteoarthritis progression: a meta-analysis. Rheumatol Int 30:357–363

    Article  CAS  PubMed  Google Scholar 

  14. Wildi LM, Raynauld JP, Martel-Pelletier J, Beaulieu A, Bessette L, Morin F, Abram F, Dorais M, Pelletier JP (2011) Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI. Ann Rheum Dis 70:982–989

    Article  PubMed  PubMed Central  Google Scholar 

  15. Pelletier JP, Yaron M, Haraoui B, Cohen P, Nahir MA, Choquette D, Wigler I, Rosner IA, Beaulieu AD (2000) Efficacy and safety of diacerein in osteoarthritis of the knee: a double-blind, placebo-controlled trial. The Diacerein Study Group. Arthritis Rheum 43:2339–2348

    Article  CAS  PubMed  Google Scholar 

  16. Dougados M, Nguyen M, Berdah L, Mazieres B, Vignon E, Lequesne M, ECHODIAH Investigators Study Group (2001) Evaluation of the structure-modifying effects of diacerein in hip osteoarthritis: ECHODIAH, a three-year, placebo-controlled trial. Evaluation of the Chondromodulating Effect of Diacerein in OA of the Hip. Arthritis Rheum 44:2539–2547

    Article  CAS  PubMed  Google Scholar 

  17. Maheu E, Mazieres B, Valat JP, Loyau G, Le Loet X, Bourgeois P, Grouin JM, Rozenberg S (1998) Symptomatic efficacy of avocado/soybean unsaponifiables in the treatment of osteoarthritis of the knee and hip: a prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial with a six-month treatment period and a two-month followup demonstrating a persistent effect. Arthritis Rheum 41:81–91

    Article  CAS  PubMed  Google Scholar 

  18. Maheu E, Cadet C, Marty M, Moyse D, Kerloch I, Coste P, Dougados M, Mazieres B, Spector TD, Halhol H, Grouin JM, Lequesne M (2014) Randomised, controlled trial of avocado-soybean unsaponifiable (Piascledine) effect on structure modification in hip osteoarthritis: the ERADIAS study. Ann Rheum Dis 73:376–384

    Google Scholar 

  19. Nuesch E, Rutjes AW, Trelle S, Reichenbach S, Juni P (2009) Doxycycline for osteoarthritis of the knee or hip. Cochrane Database Syst Rev (4):CD007323

    Google Scholar 

  20. Hellio le Graverand MP, Clemmer RS, Redifer P, Brunell RM, Hayes CW, Brandt KD, Abramson SB, Manning PT, Miller CG, Vignon E (2013) A 2-year randomised, double-blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee. Ann Rheum Dis 72:187–195

    Article  PubMed  Google Scholar 

  21. Chevalier X, Goupille P, Beaulieu AD, Burch FX, Bensen WG, Conrozier T, Loeuille D, Kivitz AJ, Silver D, Appleton BE (2009) Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum 61:344–352

    Article  CAS  PubMed  Google Scholar 

  22. Fioravanti A, Fabbroni M, Cerase A, Galeazzi M (2009) Treatment of erosive osteoarthritis of the hands by intra-articular infliximab injections: a pilot study. Rheumatol Int 29:961–965

    Article  CAS  PubMed  Google Scholar 

  23. Maksymowych WP, Russell AS, Chiu P, Yan A, Jones N, Clare T, Lambert RG (2012) Targeting tumour necrosis factor alleviates signs and symptoms of inflammatory osteoarthritis of the knee. Arthritis Res Ther 14:R206

    Article  PubMed  PubMed Central  Google Scholar 

  24. Verbruggen G, Wittoek R, Vander Cruyssen B, Elewaut D (2012) Tumour necrosis factor blockade for the treatment of erosive osteoarthritis of the interphalangeal finger joints: a double blind, randomised trial on structure modification. Ann Rheum Dis 71:891–898

    Article  CAS  PubMed  Google Scholar 

  25. Tat SK, Pelletier JP, Mineau F, Caron J, Martel-Pelletier J (2011) Strontium ranelate inhibits key factors affecting bone remodeling in human osteoarthritic subchondral bone osteoblasts. Bone 49:559–567

    Article  CAS  PubMed  Google Scholar 

  26. Martel-Pelletier J, Wildi LM, Pelletier JP (2012) Future therapeutics for osteoarthritis. Bone 51:297–311

    Article  CAS  PubMed  Google Scholar 

  27. Bruyere O, Delferriere D, Roux C, Wark JD, Spector T, Devogelaer JP, Brixen K, Adami S, Fechtenbaum J, Kolta S, Reginster JY (2008) Effects of strontium ranelate on spinal osteoarthritis progression. Ann Rheum Dis 67:335–339

    Article  CAS  PubMed  Google Scholar 

  28. Reginster JY, Badurski J, Bellamy N, Bensen W, Chapurlat R, Chevalier X, Christiansen C, Genant H, Navarro F, Nasonov E, Sambrook PN, Spector TD, Cooper C (2013) Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial. Ann Rheum Dis 72:179–186

    Article  CAS  PubMed  Google Scholar 

  29. Pelletier J-P, Roubille C, Raynauld JP, Abram F, Dorais M, Delorme P, Martel-Pelletier J (2013) Disease modifying effect of strontium ranelate in the Phase III knee osteoarthritis study SEKOIA using quantitative magnetic resonance imaging: reduction in bone marrow lesions protects against cartilage loss. Ann Rheum Dis. doi: 10.1136/annrheumdis-2013-203989

    Google Scholar 

  30. Buckland-Wright JC, Messent EA, Bingham CO 3rd, Ward RJ, Tonkin C (2007) A 2 yr longitudinal radiographic study examining the effect of a bisphosphonate (risedronate) upon subchondral bone loss in osteoarthritic knee patients. Rheumatology (Oxford) 46:257–264

    Article  CAS  Google Scholar 

  31. Bingham CO 3rd, Buckland-Wright JC, Garnero P, Cohen SB, Dougados M, Adami S, Clauw DJ, Spector TD, Pelletier JP, Raynauld JP, Strand V, Simon LS, Meyer JM, Cline GA, Beary JF (2006) Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: results of the two-year multinational knee osteoarthritis structural arthritis study. Arthritis Rheum 54:3494–3507

    Article  CAS  PubMed  Google Scholar 

  32. Sondergaard BC, Wulf H, Henriksen K, Schaller S, Oestergaard S, Qvist P, Tanko LB, Bagger YZ, Christiansen C, Karsdal MA (2006) Calcitonin directly attenuates collagen type II degradation by inhibition of matrix metalloproteinase expression and activity in articular chondrocytes. Osteoarthritis Cartilage 14:759–768

    Article  CAS  PubMed  Google Scholar 

  33. Esenyel M, Icagasioglu A, Esenyel CZ (2013) Effects of calcitonin on knee osteoarthritis and quality of life. Rheumatol Int 33:423–427

    Article  CAS  PubMed  Google Scholar 

  34. Nordic Bioscience A/S; Novartis. Efficacy and safety of oral salmon calcitonin in patients with knee osteoarthritis (OA 2 Study). In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000- [cited 2014 Mar 5]. Available from http://clinicaltrials.gov/show/NCT00704847NLMIdentifier:NCT00704847

  35. McAlindon T, LaValley M, Schneider E, Nuite M, Lee JY, Price LL, Lo G, Dawson-Hughes B (2013) Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial. JAMA 309:155–162

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Cao Y, Jones G, Cicuttini F, Winzenberg T, Wluka A, Sharman J, Nguo K, Ding C (2012) Vitamin D supplementation in the management of knee osteoarthritis: study protocol for a randomized controlled trial. Trials 13:131

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. EMD Serono; Nordic Bioscience Clinical Development AS, Herlev Denmark. A study to investigate the safety and effectiveness of different doses of sprifermin (AS902330) in patients with osteoarthritis of the knee (FORWARD). In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000- [cited 2014 Mar 5]. Available from http://clinicaltrials.gov/show/NCT01919164NLMIdentifier:NCT01919164

Download references

Author information

Authors and Affiliations

  1. Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), 900 Saint-Denis, Tour Viger, Montreal, QC, H2X 0A9, Canada

    Camille Roubille, Johanne Martel-Pelletier & Jean-Pierre Pelletier

Authors
  1. Camille Roubille
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Johanne Martel-Pelletier
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jean-Pierre Pelletier
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jean-Pierre Pelletier .

Editor information

Editors and Affiliations

  1. Institute of Metabolic Physiology, German Diabetes Center, Heinrich Heine University Düsseldorf, Düsseldorf, Germany

    Eckhard Lammert

  2. CardioMetabolic Diseases Research, Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany

    Martin Zeeb

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Wien

About this chapter

Cite this chapter

Roubille, C., Martel-Pelletier, J., Pelletier, JP. (2014). Osteoarthritis. In: Lammert, E., Zeeb, M. (eds) Metabolism of Human Diseases. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0715-7_18

Download citation

Publish with us

Policies and ethics

Search

Navigation