Skip to main content
SpringerLink
Log in

Endokrine Tumoren

  • Chapter
  • First Online:
Veterinäronkologie kompakt

  • 679 Accesses

Zusammenfassung

Die negativen Effekte von Tumoren endokriner Organe basieren vor allem auf zwei Eigenschaften, dem Masseneffekt von Primärtumor und Metastasen und zusätzlich in vielen Fällen auf dem systemischen Effekt einer erhöhten oder verminderten Hormonsekretion des Tumors bzw. geschädigten Organs. Tumoren endokriner Organe können deshalb auch wenn sie nur langsam und expansiv wachsen und somit eigentlich „gutartiges Verhalten“ zeigen, durch eine unangemessene Hormonsekretion zur schweren Schädigung des Gesamtorganismus führen. In diesem Kapitel werden wichtige Tumoren der Hypophyse, Nebenniere und Schilddrüse und der β-Zellen des Pankreas besprochen. Tumoren der Hoden und Ovarien, die ebenfalls endokrine Effekte haben können, werden in Kap. 7 beschrieben.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Weiterführende Literatur

  • Abraham LA, Helmond SE, Mitten RW, Charles JA, Holloway SA (2002) Treatment of an acromegalic cat with the dopamine agonist L-deprenyl. Aust Vet J 80: 479–483

    Article  CAS  PubMed  Google Scholar 

  • Anderson CR, Birchard SJ, Powers BE, Belandria GA, Kuntz CA, Withrow SJ (2001) Surgical treatment of adrenocortical tumors: 21 cases (1990–1996). J Am Anim Hosp Assoc 37: 93–97

    Article  CAS  PubMed  Google Scholar 

  • Antinoff N, Hahn K (2004) Ferret oncology: diseases, diagnostics, and therapeutics. Vet Clin North Am Exot Anim Pract 7: 579–625

    Article  PubMed  Google Scholar 

  • Arenas C, Perez-Alenza D, Melian C (2013) Clinical features, outcome and prognostic factors in dogs diagnosed with non-cortisol-secreting adrenal tumours without adrenalectomy: 20 cases (1994–2009). Vet Rec 173: 501

    Article  CAS  PubMed  Google Scholar 

  • Arenas C, Melian C, Perez-Alenza MD (2014) Long-term survival of dogs with adrenal-dependent hyperadrenocorticism: a comparison between mitotane and twice daily trilostane treatment. J Vet Intern Med/Am Coll Vet Inter Med 28: 473–480

    Article  CAS  Google Scholar 

  • Aronsohn MG, Schunk KL, Carpenter JL, King NW (1984) Clinical and pathologic features of thymoma in 15 dogs. J Am Vet Med Assoc 184: 1355–1362

    CAS  PubMed  Google Scholar 

  • Ash RA, Harvey AM, Tasker S (2005) Primary hyperaldosteronism in the cat: a series of 13 cases. J Feline Med Surg 7: 173–182

    Article  PubMed  Google Scholar 

  • Atwater SW, Powers BE, Park RD, Straw RC, Ogilvie GK, Withrow SJ (1994) Thymoma in dogs: 23 cases (1980–1991). J Am Vet Med Assoc 205: 1007–1013

    CAS  PubMed  Google Scholar 

  • Barber LG (2007) Thyroid tumors in dogs and cats. Vet Clin North Am Small Anim Pract 37(755–773): vii

    Google Scholar 

  • Barber PJ (2004) Disorders of the parathyroid glands. J Feline Med Surg 6: 259–269

    Article  PubMed  Google Scholar 

  • Barrera JS, Bernard F, Ehrhart EJ, Withrow SJ, Monnet E (2013) Evaluation of risk factors for outcome associated with adrenal gland tumors with or without invasion of the caudal vena cava and treated via adrenalectomy in dogs: 86 cases (1993–2009). J Am Vet Med Assoc 242: 1715–1721

    Article  PubMed  Google Scholar 

  • Beech J, Boston RC, McFarlane D, Lindborg S (2009) Evaluation of plasma ACTH, alpha-melanocyte-stimulating hormone, and insulin concentrations during various photoperiods in clinically normal horses and ponies and those with pituitary pars intermedia dysfunction. J Am Vet Med Assoc 235: 715–722

    Article  CAS  PubMed  Google Scholar 

  • Benchekroun G, de Fornel-Thibaud P, Rodriguez Pineiro MI, Rault D, Besso J, Cohen A, Hernandez J, Stambouli F, Gomes E, Garnier F, Begon D, Maurey-Guenec C, Rosenberg D (2010) Ultrasonography criteria for differentiating ACTH dependency from ACTH independency in 47 dogs with hyperadrenocorticism and equivocal adrenal asymmetry. J Vet Intern Med/Am Coll Vet Intern Med 24: 1077–1085

    Article  CAS  Google Scholar 

  • Bennett KR, Gaunt MC, Parker DL (2015) Constant rate infusion of glucagon as an emergency treatment for hypoglycemia in a domestic ferret (Mustela putorius furo). J Am Vet Med Assoc 246: 451–454

    Article  PubMed  Google Scholar 

  • Berg RIM, Nelson RW, Feldman EC, Kass PH, Pollard R, Refsal KR (2007) Serum insulin-like growth factor-I concentration in cats with diabetes mellitus and acromegaly. J Vet Intern Med 21: 892–898

    Article  PubMed  Google Scholar 

  • Bertazzolo W, Didier M, Gelain ME, Rossi S, Crippa L, Avallone G, Roccabianca P, Bonfanti U, Giori L, Fracassi F (2014) Accuracy of cytology in distinguishing adrenocortical tumors from pheochromocytoma in companion animals. Vet Clin Pathol/Am Soc Vet Clin Pathol 43: 453–459

    Article  Google Scholar 

  • Boag AK, Neiger R, Church DB (2004) Trilostane treatment of bilateral adrenal enlargement and excessive sex steroid hormone production in a cat. J Small Anim Pract 45: 263–266

    Article  CAS  PubMed  Google Scholar 

  • Bonczynski J (2007) Primary hyperparathyroidism in dogs and cats. Clin Tech Small Anim Pract 22: 70–74

    Article  PubMed  Google Scholar 

  • Brearley MJ, Polton GA, Littler RM, Niessen SJM (2006) Coarse fractionated radiation therapy for pituitary tumours in cats: a retrospective study of 12 cases. Vet Comp Oncol 4: 209–217

    Article  CAS  PubMed  Google Scholar 

  • Brito Galvao de JF, Chew DJ (2011) Metabolic complications of endocrine surgery in companion animals. The Veterinary clinics of North America. Small Animal Pract 41: 847–868

    Article  Google Scholar 

  • Buishand FO, Kik M, Kirpensteijn J (2010) Evaluation of clinico-pathological criteria and the Ki67 index as prognostic indicators in canine insulinoma. Vet J 185: 62–67

    Article  CAS  PubMed  Google Scholar 

  • Buishand FO, van Erp MG, Groenveld HA, Mol JA, Kik M, Robben JH, Kooistra HS, Kirpensteijn J (2012) Expression of insulin-like growth factor–1 by canine insulinomas and their metastases. Vet J 191: 334–340

    Article  CAS  PubMed  Google Scholar 

  • Buishand FO, Visser J, Kik M, Grone A, Keesler RI, Briaire-de Bruijn IH, Kirpensteijn J (2014) Evaluation of prognostic indicators using validated canine insulinoma tissue microarrays. Vet J 201: 57–63

    Article  CAS  PubMed  Google Scholar 

  • Caplan ER, Peterson ME, Mullen HS, Quesenberry KE, Rosenthal KL, Hoefer HL, Moroff SD (1996) Diagnosis and treatment of insulin-secreting pancreatic islet cell tumors in ferrets: 57 cases (1986–1994). J Am Vet Med Assoc 209: 1741–1745

    CAS  PubMed  Google Scholar 

  • Cavalcanti JV, Moura MP, Monteiro FO (2014) Thymoma associated with exfoliative dermatitis in a cat. J Feline Med Surg 16: 1020–1023

    Article  PubMed  Google Scholar 

  • Caywood DD, Klausner JS, O’Leary TP (1988) Pancreatic insulin-secreting neoplasms: clinical, diagnostic, and prognostic features in 73 dogs. J Am Anim Hosp Assoc 24: 577–584

    Google Scholar 

  • Chen S (2008) Pancreatic endocrinopathies in ferrets. Vet Clin North Am Exot Anim Pract 11(107–123): vii

    Google Scholar 

  • Chen S (2010) Advanced diagnostic approaches and current medical management of insulinomas and adrenocortical disease in ferrets (Mustela putorius furo). Vet Clin North Am Exot Anim Pract 13: 439–452

    Article  CAS  PubMed  Google Scholar 

  • Combes A, Pey P, Paepe D, Rosenberg D, Daminet S, Putcuyps I, Bedu AS, Duchateau L, de Fornel-Thibaud P, Benchekroun G, Saunders JH (2013) Ultrasonographic appearance of adrenal glands in healthy and sick cats. J Feline Med Surg 15: 445–457

    Article  PubMed  Google Scholar 

  • Cordner AP, Sharkey LC, Armstrong PJ, McAteer KD (2015) Cytologic findings and diagnostic yield in 92 dogs undergoing fine-needle aspiration of the pancreas. J Vet Diagn Invest Off Publ Am Assoc Vet Lab Diagn Inc 27: 236–240

    Article  Google Scholar 

  • Daminet S, Kooistra HS, Fracassi F, Graham PA, Hibbert A, Lloret A, Mooney CT, Neiger R, Rosenberg D, Syme HM, Villard I, Williams G (2014) Best practice for the pharmacological management of hyperthyroid cats with antithyroid drugs. J Small Anim Pract 55: 4–13

    Article  CAS  PubMed  Google Scholar 

  • Daniel G, Mahony OM, Markovich JE, Appleman E, Monaghan KN, Lawrence YA, Fiocchi EH, Weaver K, Johnston A, Barton B (2015) Clinical findings, diagnostics and outcome in 33 cats with adrenal neoplasia (2002–2013). J Feline Med Surg 18(2): 77–84

    Article  PubMed  Google Scholar 

  • Daniel GB, Neelis DA (2014) Thyroid scintigraphy in veterinary medicine. Semin Nucl Med 44: 24–34

    Article  PubMed  Google Scholar 

  • Davis MK, Schochet RA, Wrigley R (2012) Ultrasonographic identification of vascular invasion by adrenal tumors in dogs. Vet Radiol Ultrasound Off J Am Coll Vet Radiol Int Vet Radiol Assoc 53: 442–445

    Article  Google Scholar 

  • Diez de Castro E, Lopez I, Cortes B, Pineda C, Garfia B, Aguilera-Tejero E (2014) Influence of feeding status, time of the day, and season on baseline adrenocorticotropic hormone and the response to thyrotropin releasing hormone-stimulation test in healthy horses. Domest Anim Endocrinol 48: 77–83

    Article  CAS  PubMed  Google Scholar 

  • Dirtu AC, Niessen SJM, Jorens PG, Covaci A (2013) Organohalogenated contaminants in domestic cats’ plasma in relation to spontaneous acromegaly and type 2 diabetes mellitus: a clue for endocrine disruption in humans?. Environ Int 57–58: 60–67

    Article  PubMed  CAS  Google Scholar 

  • Djajadiningrat-Laanen S, Galac S, Kooistra H (2011) Primary hyperaldosteronism: expanding the diagnostic net. J Feline Med Surg 13: 641–650

    Article  PubMed  Google Scholar 

  • Edinboro CH, Scott-Moncrieff JC, Glickman LT (2010) Feline hyperthyroidism: potential relationship with iodine supplement requirements of commercial cat foods. J Feline Med Surg 12: 672–679

    Article  PubMed  Google Scholar 

  • Ehrhart N, Mitrow SJ, Ehrhart EJ, Wimsatt JH (1996) Pancreatic beta cell tumor in ferrets: 20 cases (1986–1994). J Am Vet Med Assoc 209: 1737–1740

    CAS  PubMed  Google Scholar 

  • Elliott DA, Feldman EC, Koblik PD, Samii VF, Nelson RW (2000) Prevalence of pituitary tumors among diabetic cats with insulin resistance. J Am Vet Med Assoc 216: 1765–1768

    Article  CAS  PubMed  Google Scholar 

  • Feldman EC, Hoar B, Pollard R, Nelson RW (2005) Pretreatment clinical and laboratory findings in dogs with primary hyperparathyroidism: 210 cases (1987–2004). J Am Vet Med Assoc 227: 756–761

    Article  PubMed  Google Scholar 

  • Feldman EC, Nelson RW, Feldman MS, Farver TB (1992) Comparison of mitotane treatment for adrenal tumor versus pituitary-dependent hyperadrenocorticism in dogs. J Am Vet Med Assoc 200: 1642–1647

    CAS  PubMed  Google Scholar 

  • Feldman EC, Wisner ER, Nelson RW, Feldman MS, Kennedy PC (1997) Comparison of results of hormonal analysis of samples obtained from selected venous sites versus cervical ultrasonography for localizing parathyroid masses in dogs. J Am Vet Med Assoc 211: 54–56

    CAS  PubMed  Google Scholar 

  • Fineman LS, Hamilton TA, de Gortari A, Bonney P (1998) Cisplatin chemotherapy for treatment of thyroid carcinoma in dogs: 13 cases. J Am Anim Hosp Assoc 34: 109–112

    Article  CAS  PubMed  Google Scholar 

  • Fischetti AJ, Gisselman K, Peterson ME (2012) Ct and Mri evaluation of skull bones and soft tissues in six cats with presumed acromegaly versus 12 unaffected cats. Vet Radiol Ultrasound 53: 535–539

    Article  PubMed  Google Scholar 

  • Friedrich-Rust M, Glasemann T, Polta A, Eichler K, Holzer K, Kriener S, Herrmann E, Nierhoff J, Bon D, Bechstein WO, Vogl T, Zeuzem S, Bojunga J (2011) Differentiation between benign and malignant adrenal mass using contrast-enhanced ultrasound. Ultraschall in der Medizin 32: 460–471

    Article  CAS  PubMed  Google Scholar 

  • Fukazawa K, Kayanuma H, Kanai E, Sakata M, Shida T, Suganuma T (2009) Insulinoma with basal ganglion involvement detected by magnetic resonance imaging in a dog. J Vet Med Sci/Jap Soc Vet Sci 71: 689–692

    Article  Google Scholar 

  • Gilson SD, Withrow SJ, Wheeler SL, Twedt DC (1994) Pheochromocytoma in 50 dogs. J Vet Int Med/Am Coll Vet Int Med 8: 228–232

    Article  CAS  Google Scholar 

  • Goldstein LJ, Galski H, Fojo A, Willingham M, Lai SL, Gazdar A, Pirker R, Green A, Crist W, Brodeur GMet al.1989Expression of a multidrug resistance gene in human cancersJ Natl Cancer Inst81116–124

    Article  CAS  PubMed  Google Scholar 

  • Gostelow R, Bridger N, Syme HM (2013) Plasma-free metanephrine and free normetanephrine measurement for the diagnosis of pheochromocytoma in dogs. J Vet Int Med/Am Coll Vet Int Med 27: 83–90

    Article  CAS  Google Scholar 

  • Goutal CM, Brugmann BL, Ryan KA (2012) Insulinoma in dogs: a review.. J Am Anim Hosp Assoc 48: 151–163

    Article  PubMed  Google Scholar 

  • Greco DS (2012) Feline acromegaly. Top Companion Anim M 27: 31–35

    Article  Google Scholar 

  • Gregori T, Mantis P, Benigni L, Priestnall SL, Lamb CR (2015) Comparison of computed tomographic and pathologic findings in 17 dogs with primary adrenal neoplasia. Vet Radiol Ultrasound Off J Am Coll Vet Radiol Int Vet Radiol Assoc 56: 153–159

    Article  Google Scholar 

  • Ham K, Greenfield CL, Barger A, Schaeffer D, Ehrhart EJ, Pinkerton M, Valli VE (2009) Validation of a rapid parathyroid hormone assay and intraoperative measurement of parathyroid hormone in dogs with benign naturally occurring primary hyperparathyroidism. Vet Surg 38: 122–132

    Article  PubMed  Google Scholar 

  • Helm JR, McLauchlan G, Boden LA, Frowde PE, Collings AJ, Tebb AJ, Elwood CM, Herrtage ME, Parkin TD, Ramsey IK (2011) A comparison of factors that influence survival in dogs with adrenal-dependent hyperadrenocorticism treated with mitotane or trilostane. J Vet Intern Med/ Am Coll Vet Int Med 25: 251–260

    Article  CAS  Google Scholar 

  • Herrera MA, Mehl ML, Kass PH, Pascoe PJ, Feldman EC, Nelson RW (2008) Predictive factors and the effect of phenoxybenzamine on outcome in dogs undergoing adrenalectomy for pheochromocytoma. J Vet Intern Med/Am Coll Vet Int Med 22: 1333–1339

    Article  CAS  Google Scholar 

  • Hibbert A, Gruffydd-Jones T, Barrett EL, Day MJ, Harvey AM (2009) Feline thyroid carcinoma: diagnosis and response to high-dose radioactive iodine treatment. J Feline Med Surg 11: 116–124

    Article  PubMed  Google Scholar 

  • Higgs P, Hibbert A (2012) Managing hyperthyroidism in cats. Vet Rec 171: 225–226

    Article  PubMed  Google Scholar 

  • Hunt GB, Churcher RK, Church DB, Mahoney P (1997) Excision of a locally invasive thymoma causing cranial vena cava syndrome in a dog. J Am Vet Med Assoc 210: 1628–1630

    CAS  PubMed  Google Scholar 

  • Hurty CA, Flatland B (2005) Feline acromegaly: a review of the syndrome. J Am Anim Hosp Assoc 41: 292–297

    Article  PubMed  Google Scholar 

  • Iseri T, Yamada K, Chijiwa K, Nishimura R, Matsunaga S, Fujiwara R, Sasaki N (2007) Dynamic computed tomography of the pancreas in normal dogs and in a dog with pancreatic insulinoma. Vet Radiol Ultrasound Off J Am Coll Vet Radiol Int Vet Radiol Assoc 48: 328–331

    Article  Google Scholar 

  • Javadi S, Slingerland LI, van de Beek MG, Boer P, Boer WH, Mol JA, Rijnberk A, Kooistra HS (2004) Plasma renin activity and plasma concentrations of aldosterone, cortisol, adrenocorticotropic hormone, and alpha-melanocyte- stimulating hormone in healthy cats. J Vet Intern Med/Am Coll Vet Int Med 18: 625–631

    Google Scholar 

  • Jensen KB, Forcada Y, Church DB, Niessen SJM (2015) Evaluation and diagnostic potential of serum ghrelin in feline hypersomatotropism and diabetes mellitus. J Vet Intern Med 29: 14–20

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kaser-Hotz B, Rohrer CR, Stankeova S, Wergin M, Fidel J, Reusch C (2002) Radiotherapy of pituitary tumours in five cats. J Small Anim Pract 43: 303–307

    Article  CAS  PubMed  Google Scholar 

  • Kent MS, Bommarito D, Feldman E, Theon AP (2007) Survival, neurologic response, and prognostic factors in dogs with pituitary masses treated with radiation therapy and untreated dogs. J Vet Intern Med/Am Coll Vet Int Med 21: 1027–1033

    Article  Google Scholar 

  • Kooistra HS (2014) Feline hyperthyroidism: a common disorder with unknown pathogenesis. Vet Rec 175: 456–457

    Article  PubMed  Google Scholar 

  • Kyles AE, Feldman EC, De Cock HE, Kass PH, Mathews KG, Hardie EM, Nelson RW, Ilkiw JE, Gregory CR (2003) Surgical management of adrenal gland tumors with and without associated tumor thrombi in dogs: 40 cases (1994–2001). J Am Vet Med Assoc 223: 654–662

    Article  PubMed  Google Scholar 

  • Labelle P, Kyles AE, Farver TB, De Cock HE (2004) Indicators of malignancy of canine adrenocortical tumors: histopathology and proliferation index. Vet Pathol 41: 490–497

    Article  CAS  PubMed  Google Scholar 

  • Lamb CR, Ciasca TC, Mantis P, Forcada Y, Potter M, Church DB, Niessen SJ (2014) Computed tomographic signs of acromegaly in 68 diabetic cats with hypersomatotropism. J Feline Med Surg 16: 99–108

    Article  PubMed  Google Scholar 

  • Lamb CR, Simpson KW, Boswood A, Matthewman LA (1995) Ultrasonography of pancreatic neoplasia in the dog: a retrospective review of 16 cases. Vet Rec 137: 65–68

    Article  CAS  PubMed  Google Scholar 

  • Lang JM, Schertel E, Kennedy S, Wilson D, Barnhart M, Danielson B (2011) Elective and emergency surgical management of adrenal gland tumors: 60 cases (1999–2006). J Am Anim Hosp Assoc 47: 428–435

    Article  PubMed  Google Scholar 

  • Larson RN, Schmiedt CW, Wang A, Lawrence J, Howerth EW, Holmes SP, Grey SW (2013) Adrenal gland function in a dog following unilateral complete adrenalectomy and contralateral partial adrenalectomy. J Am Vet Med Assoc 242: 1398–1404

    Article  CAS  PubMed  Google Scholar 

  • Lautenschlaeger IE, Hartmann A, Sicken J, Mohrs S, Scholz VB, Neiger R, Kramer M (2013) Comparison between computed tomography and (99m)TC- pertechnetate scintigraphy characteristics of the thyroid gland in cats with hyperthyroidism. Vet Radiol Ultrasound Off J Am Coll Vet Radiol Int Vet Radiol Assoc 54: 666–673

    Google Scholar 

  • Li X, Fox JG, Padrid PA (1998) Neoplastic diseases in ferrets: 574 cases (1968–1997). J Am Vet Med Assoc 212: 1402–1406

    CAS  PubMed  Google Scholar 

  • Liles SR, Linder KE, Cain B, Pease AP (2010) Ultrasonography of histologically normal parathyroid glands and thyroid lobules in normocalcemic dogs. Vet Radiol Ultrasound Off J Am Coll Vet Radiol Int Vet Radiol Assoc 51: 447–452

    Article  Google Scholar 

  • Littler RM, Polton GA, Brearley MJ (2006) Resolution of diabetes mellitus but not acromegaly in a cat with a pituitary macroadenoma treated with hypofractionated radiation. J Small Anim Pract 47: 392–395

    Article  CAS  PubMed  Google Scholar 

  • Llabres-Diaz FJ, Dennis R (2003) Magnetic resonance imaging of the presumed normal canine adrenal glands. Vet Radiol Ultrasound Off J Am Coll Vet Radiol Int Vet Radiol Assoc 44: 5–19

    Article  Google Scholar 

  • Lo AJ, Holt DE, Brown DC, Schlicksup MD, Orsher RJ, Agnello KA (2014) Treatment of aldosterone-secreting adrenocortical tumors in cats by unilateral adrenalectomy: 10 cases (2002–2012). J Vet Int Med/Am Coll Vet Int Med 28: 137–143

    Article  CAS  Google Scholar 

  • Long CD, Goldstein RE, Hornof WJ, Feldman EC, Nyland TG (1999) Percutaneous ultrasound-guided chemical parathyroid ablation for treatment of primary hyperparathyroidism in dogs. J Am Vet Med Assoc 215: 217–221

    CAS  PubMed  Google Scholar 

  • Madarame H, Kayanuma H, Shida T, Tsuchiya R (2009) Retrospective study of canine insulinomas: eight cases (2005–2008). J Vet Med Sci/Jap Soc Vet Sci 71: 905–911

    Article  Google Scholar 

  • Maggio F, DeFrancesco TC, Atkins CE, Pizzirani S, Gilger BC, Davidson MG (2000) Ocular lesions associated with systemic hypertension in cats: 69 cases (1985–1998). J Am Vet Med Assoc 217: 695–702

    Article  CAS  PubMed  Google Scholar 

  • Massari F, Nicoli S, Romanelli G, Buracco P, Zini E (2011) Adrenalectomy in dogs with adrenal gland tumors: 52 cases (2002–2008). J Am Vet Med Assoc 239: 216–221

    Article  PubMed  Google Scholar 

  • Mastro LM, Adams AA, Urschel KL (2015) Pituitary pars intermedia dysfunction does not necessarily impair insulin sensitivity in old horses. Domest Anim Endocrinol 50: 14–25

    Article  CAS  PubMed  Google Scholar 

  • Mayer MN, Treuil PL (2007) Radiation therapy for pituitary tumors in the dog and cat. Can Vet J La revue veterinaire canadienne 48: 316–318

    Google Scholar 

  • McFarlane D (2011) Equine pituitary pars intermedia dysfunction. Vet Clin North Am Equine Pract 27: 93–113

    Article  PubMed  Google Scholar 

  • McGowan TW, Pinchbeck GP, McGowan CM (2013a) Evaluation of basal plasma alpha-melanocyte-stimulating hormone and adrenocorticotrophic hormone concentrations for the diagnosis of pituitary pars intermedia dysfunction from a population of aged horses. Equine Vet J 45: 66–73

    Article  CAS  Google Scholar 

  • McGowan TW, Pinchbeck GP, McGowan CM (2013b) Prevalence, risk factors and clinical signs predictive for equine pituitary pars intermedia dysfunction in aged horses. Equine Vet J 45: 74–79

    Article  CAS  PubMed  Google Scholar 

  • Meij BP, Auriemma E, Grinwis G, Buijtels JJCWM, Kooistra HS (2010) Successful treatment of acromegaly in a diabetic cat with transsphenoidal hypophysectomy. J Feline Med Surg 12: 406–410

    Article  PubMed  Google Scholar 

  • Meleo KA (1997) The role of radiotherapy in the treatment of lymphoma and thymoma. Vet Clin North Am Small Anim Pract 27: 115–129

    Article  CAS  PubMed  Google Scholar 

  • Milovancev M, Schmiedt CW (2013) Preoperative factors associated with postoperative hypocalcemia in dogs with primary hyperparathyroidism that underwent parathyroidectomy: 62 cases (2004–2009). J Am Vet Med Assoc 242: 507–515

    Article  CAS  PubMed  Google Scholar 

  • Moore AS, Nelson RW, Henry CJ, Rassnick KM, Kristal O, Ogilvie GK, Kintzer P (2002) Streptozocin for treatment of pancreatic islet cell tumors in dogs: 17 cases (1989–1999). J Am Vet Med Assoc 221: 811–818

    Article  CAS  PubMed  Google Scholar 

  • Moore LE, Biller DS, Smith TA (2000) Use of abdominal ultrasonography in the diagnosis of primary hyperaldosteronism in a cat. J Am Vet Med Assoc 217(213–215): 197

    Google Scholar 

  • Moore SA, O’Brien DP (2008) Canine pituitary macrotumors. Compendium 30: 33–40 quiz 41

    PubMed  Google Scholar 

  • Morrison SA, Randolph J, Lothrop CD (1989) Hypersomatotropism and insulin-resistant diabetesmellitus in a Cat. J Am Vet Med Assoc 194: 91–94

    CAS  PubMed  Google Scholar 

  • Myers NC 3rd, Bruyette DS (1994) Feline adrenocortical diseases: part I–hyperadrenocorticism. Semin Vet Med Surg 9: 137–143

    Google Scholar 

  • Naan EC, Kirpensteijn J, Dupre GP, Galac S, Radlinsky MG (2013) Innovative approach to laparoscopic adrenalectomy for treatment of unilateral adrenal gland tumors in dogs. Vet Surg 42: 710–715

    Article  PubMed  Google Scholar 

  • Nakamura K, Lim SY, Ochiai K, Yamasaki M, Ohta H, Morishita K, Takagi S, Takiguchi M (2015) Contrast-enhanced ultrasonographic findings in three dogs with pancreatic insulinoma. Vet Radiol Ultrasound Off J Am Coll Vet Radiol Int Vet Radiol Assoc 56: 55–62

    Article  Google Scholar 

  • Neiger R, Witt AL, Noble A, German AJ (2004) Trilostane therapy for treatment of pituitary-dependent hyperadrenocorticism in 5 cats. J Vet Int Med/Am Coll Vet Int Med 18: 160–164

    Article  Google Scholar 

  • Nichols R (1997) Complications and concurrent disease associated with canine hyperadrenocorticism. Vet Clin North Am Small Anim Pract 27: 309–320

    Article  CAS  PubMed  Google Scholar 

  • Niessen S (2010) Feline acromegaly: an essential differential diagnosis for the difficult diabetic. J Feline Med Surg 12: 15–23

    Article  PubMed  Google Scholar 

  • Niessen SJ, Khalid M, Petrie G, Church DB (2007a) Validation and application of a radioimmunoassay for ovine growth hormone in the diagnosis of acromegaly in cats. Vet Rec 160: 902–907

    Article  CAS  PubMed  Google Scholar 

  • Niessen SJ, Petrie G, Gaudiano F, Khalid M, Smyth JB, Mahoney P, Church DB (2007b) Feline acromegaly: an underdiagnosed endocrinopathy?. J Vet Int Med/Am Coll Vet Int Med 21: 899–905

    Article  CAS  Google Scholar 

  • Niessen SJM, Church DB, Forcada Y (2013) Hypersomatotropism, acromegaly, and hyperadrenocorticism and feline diabetes mellitus. Vet Clin N Am-Small 43: 319–350

    Article  Google Scholar 

  • Norman EJ, Mooney CT (2000) Diagnosis and management of diabetes mellitus in five cats with somatotrophic abnormalities. J Feline Med Surg 2: 183–190

    Article  CAS  PubMed  Google Scholar 

  • Northrup NC, Rassnick KM, Gieger TL, Kosarek CE, McFadden CW, Rosenberg MP (2013) Prospective evaluation of biweekly streptozotocin in 19 dogs with insulinoma. J Vet Int Med/Am Coll Vet Int Med 27: 483–490

    Article  CAS  Google Scholar 

  • Owen LN (1980) Skeletal tumors. In: TNM classification of tumours in domestic, 1st edn. World Health Organization, Geneva, pp 66–67

    Google Scholar 

  • Pack L, Roberts RE, Dawson SD, Dookwah HD (2001) Definitive radiation therapy for infiltrative thyroid carcinoma in dogs. Vet Radiol Ultrasound 42: 471–474

    Article  CAS  PubMed  Google Scholar 

  • Peterson M (2012) Hyperthyroidism in cats: what’s causing this epidemic of thyroid disease and can we prevent it?. J Feline Med Surg 14: 804–818

    Article  PubMed  Google Scholar 

  • Peterson ME (2007) Acromegaly in cats: are we only diagnosing the tip of the iceberg?. J Vet Int Med/Am Coll Vet Int Med 21: 889–891

    Article  Google Scholar 

  • Peterson ME (2013a) Feline focus: diagnostic testing for feline thyroid disease: hyperthyroidism. Compendium 35: E3

    PubMed  Google Scholar 

  • Peterson ME (2013b) More than just T(4): diagnostic testing for hyperthyroidism in cats. J Feline Med Surg 15: 765–777

    Article  PubMed  Google Scholar 

  • Peterson ME, Broome MR (2015) Thyroid scintigraphy findings in 2096 cats with hyperthyroidism. Vet Radiol Ultrasound Off J Am Coll Vet Radiol Int Vet Radiol Assoc 56: 84–95

    Article  Google Scholar 

  • Peterson ME, Taylor RS, Greco DS, Nelson RW, Randolph JF, Foodman MS, Moroff SD, Morrison SA, Lothrop CD (1990) Acromegaly in 14 cats. J Vet Intern Med 4: 192–201

    Article  CAS  PubMed  Google Scholar 

  • Peterson ME, Ward CR (2007) Etiopathologic findings of hyperthyroidism in cats. The Veterinary clinics of North America. Small Anim Pract 37: 633–645

    Article  Google Scholar 

  • Pey P, Rossi F, Vignoli M, Duchateau L, Marescaux L, Saunders JH (2014) Use of contrast-enhanced ultrasonography to characterize adrenal gland tumors in dogs. Am J Vet Res 75: 886–892

    Article  PubMed  Google Scholar 

  • Phair KA, Carpenter JW, Schermerhorn T, Ganta CK, DeBey BM (2011) Diabetic ketoacidosis with concurrent pancreatitis, pancreatic beta islet cell tumor, and adrenal disease in an obese ferret (Mustela putorius furo). Am Assoc Lab Anim Sci JAALAS 50: 531–535

    CAS  PubMed  Google Scholar 

  • Pollard RE, Bohannon LK, Feldman EC (2015) Prevalence of incidental thyroid nodules in ultrasound studies of dogs with hypercalcemia (2008–2013). Vet Radiol Ultrasound Off J Am Coll Vet Radiol Int Vet Radiol Assoc 56: 63–67

    Article  Google Scholar 

  • Pollard RE, Long CD, Nelson RW, Hornof WJ, Feldman EC (2001) Percutaneous ultrasonographically guided radiofrequency heat ablation for treatment of primary hyperparathyroidism in dogs. J Am Vet Med Assoc 218: 1106–1110

    Article  CAS  PubMed  Google Scholar 

  • Pollard RE, Reilly CM, Uerling MR, Wood FD, Feldman EC (2010) Cross-sectional imaging characteristics of pituitary adenomas, invasive adenomas and adenocarcinomas in dogs: 33 cases (1988–2006). J Vet Int Med/Am Coll Vet Int Med 24: 160–165

    Article  Google Scholar 

  • Polton GA, White RN, Brearley MJ, Eastwood JM (2007) Improved survival in a retrospective cohort of 28 dogs with insulinoma. J Small Anim Pract 48: 151–156

    Article  CAS  PubMed  Google Scholar 

  • Popovitch CA, Weinstein MJ, Goldschmidt MH (1994) Chondrosarcoma: a retrospective study of 97 dogs (1987–1990). J Am Anim Hosp Assoc 30: 81–85

    Google Scholar 

  • Posch B, Dobson J, Herrtage M (2011) Magnetic resonance imaging findings in 15 acromegalic cats. Vet Radiol Ultrasound 52: 422–427

    Article  PubMed  Google Scholar 

  • Radlinsky MG (2007) Thyroid surgery in dogs and cats. Vet Clin N Am-Small 37: 789–798

    Article  Google Scholar 

  • Rasmussen SH, Andersen HH, Kjelgaard-Hansen M (2014) Combined assessment of serum free and total T4 in a general clinical setting seemingly has limited potential in improving diagnostic accuracy of thyroid dysfunction in dogs and cats. Vet Clin Pathol/Am Soc Vet Clin Pathol 43: 1–3

    Article  Google Scholar 

  • Rasor L, Pollard R, Feldman EC (2007) Retrospective evaluation of three treatment methods for primary hyperparathyroidism in dogs. J Am Anim Hosp Assoc 43: 70–77

    Article  PubMed  Google Scholar 

  • Robben JH, Pollak YW, Kirpensteijn J, Boroffka SA, van den Ingh TS, Teske E, Voorhout G (2005) Comparison of ultrasonography, computed tomography, and single-photon emission computed tomography for the detection and localization of canine insulinoma. J Vet Int Med/Am Coll Vet Int Med 19: 15–22

    Article  Google Scholar 

  • Robben JH, van den Brom WE, Mol JA, van Haeften TW, Rijnberk A (2006) Effect of octreotide on plasma concentrations of glucose, insulin, glucagon, growth hormone, and cortisol in healthy dogs and dogs with insulinoma. Res Vet Sci 80: 25–32

    Article  CAS  PubMed  Google Scholar 

  • Rosenstein DS (2000) Diagnostic imaging in canine pheochromocytoma. Vet Radiol Ultrasound Off J Am Coll Vet Radiol Int Vet Radiol Assoc 41: 499–506

    Article  CAS  Google Scholar 

  • Salesov E, Boretti FS, Sieber-Ruckstuhl NS, Rentsch KM, Riond B, Hofmann-Lehmann R, Kircher PR, Grouzmann E, Reusch CE (2015) Urinary and plasma catecholamines and metanephrines in dogs with pheochromocytoma, hypercortisolism, nonadrenal disease and in healthy dogs. J Vet Int Med/Am Coll Vet Int Med 29: 597–602

    Article  CAS  Google Scholar 

  • Sangster JK, Panciera DL, Abbott JA (2013) Cardiovascular effects of thyroid disease. Compendium 35: E5

    PubMed  Google Scholar 

  • Scavelli TD, Peterson ME, Matthiesen DT (1986) Results of surgical treatment for hyperadrenocorticism caused by adrenocortical neoplasia in the dog: 25 cases (1980–1984). J Am Vet Med Assoc 189: 1360–1364

    CAS  PubMed  Google Scholar 

  • Schaefer C, Goldstein RE (2009) Canine primary hyperparathyroidism. Compendium 31: 382–389; quiz 390

    PubMed  Google Scholar 

  • Schulman RL (2010) Feline primary hyperaldosteronism. Vet Clin North Am Small Anim Pract 40: 353–359

    Article  PubMed  Google Scholar 

  • Schultz RM, Wisner ER, Johnson EG, MacLeod JS (2009) Contrast-enhanced computed tomography as a preoperative indicator of vascular invasion from adrenal masses in dogs. Vet Radiol Ultrasound Off J Am Coll Vet Radiol Int Vet Radiol Assoc 50: 625–629

    Article  Google Scholar 

  • Schwartz P, Kovak JR, Koprowski A, Ludwig LL, Monette S, Bergman PJ (2008) Evaluation of prognostic factors in the surgical treatment of adrenal gland tumors in dogs: 41 cases (1999–2005). J Am Vet Med Assoc 232: 77–84

    Article  PubMed  Google Scholar 

  • Schwedes CS (1997) Mitotane (o, p'-DDD) treatment in a cat with hyperadrenocorticism. J Small Anim Pract 38: 520–524

    Article  CAS  PubMed  Google Scholar 

  • Scott-Moncrieff JC (2012) Thyroid disorders in the geriatric veterinary patient. Vet Clin North Am Small Anim Pract 42(707–725): vi–vii

    Google Scholar 

  • Sellon RK, Fidel J, Houston R, Gavin PR (2009) Linear-accelerator- based modified radiosurgical treatment of pituitary tumors in cats: 11 cases (1997–2008). J Vet Intern Med 23: 1038–1044

    Article  CAS  PubMed  Google Scholar 

  • Shiel RE, Mooney CT (2007) Testing for hyperthyroidism in cats. Vet Clin North Am Small Anim Pract 37(671–691): vi

    Google Scholar 

  • Shilo Y, Pypendop BH, Barter LS, Epstein SE (2011) Thymoma removal in a cat with acquired myasthenia gravis: a case report and literature review of anesthetic techniques. Vet Anaesth Analg 38: 603–613

    Article  CAS  PubMed  Google Scholar 

  • Singh A, Boston SE, Poma R (2010) Thymoma-associated exfoliative dermatitis with post-thymectomy myasthenia gravis in a cat. Can Vet J La revue veterinaire canadienne 51: 757–760

    Google Scholar 

  • Skelly BJ, Franklin RJ (2007) Mutations in genes causing human familial isolated hyperparathyroidism do not account for hyperparathyroidism in Keeshond dogs. Vet J 174: 652–654

    Article  CAS  PubMed  Google Scholar 

  • Slingerland LI, Voorhout G, Rijnberk A, Kooistra HS (2008) Growth hormone excess and the effect of octreotide in cats with diabetes mellitus. Domest Anim Endocrinol 35: 352–361

    Article  CAS  PubMed  Google Scholar 

  • Sluijs van FJ, Sjollema BE, Voorhout G, Van Den Ingh TS, Rijnberk A (1995) Results of adrenalectomy in 36 dogs with hyperadrenocorticism caused by adreno-cortical tumour. Vet Q 17: 113–116

    Article  Google Scholar 

  • Spadavecchia C, Jaggy A (2008) Thymectomy in a cat with myasthenia gravis: a case report focusing on perianaesthetic management. Schweiz Arch Tierheilkd 150: 515–518

    Article  CAS  PubMed  Google Scholar 

  • Syme HM, Fletcher MG, Bailey SR, Elliott J (2007) Measurement of aldosterone in feline, canine and human urine. J Small Anim Pract 48: 202–208

    Article  CAS  PubMed  Google Scholar 

  • Taeymans O, Dennis R, Saunders JH (2008) Magnetic resonance imaging of the normal canine thyroid gland. Vet Radiol Ultrasound 49: 238–242

    Article  PubMed  Google Scholar 

  • Tobin RL, Nelson RW, Lucroy MD, Wooldridge JD, Feldman EC (1999) Outcome of surgical versus medical treatment of dogs with beta cell neoplasia: 39 cases (1990–1997). J Am Vet Med Assoc 215: 226–230

    CAS  PubMed  Google Scholar 

  • Trepanier LA (2006) Medical management of hyperthyroidism. Clin Tech Small Anim Pract 21: 22–28

    Article  PubMed  Google Scholar 

  • Trepanier LA (2007) Pharmacologic management of feline hyperthyroidism. Vet Clin North Am Small Anim Pract 37(775–788): vii

    Google Scholar 

  • Trifonidou MA, Kirpensteijn J, Robben JH (1998) A retrospective evaluation of 51 dogs with insulinoma. Vet Q 20(Suppl 1): S114–S115

    Article  PubMed  Google Scholar 

  • Turrel JM, McEntee MC, Burke BP, Page RL (2006) Sodium iodide I 131 treatment of dogs with nonresectable thyroid tumors: 39 cases (1990–2003). Javma-J Am Vet Med A 229: 542–548

    Article  CAS  Google Scholar 

  • Vanderperren K, Haers H, Van der Vekens E, Stock E, Paepe D, Daminet S, Saunders JH (2014) Description of the use of contrast-enhanced ultrasonography in four dogs with pancreatic tumours. J Small Anim Pract 55: 164–169

    Article  CAS  PubMed  Google Scholar 

  • Volckaert V, Vandermeulen E, Dobbeleir A, Duchateau L, Saunders JH, Peremans K (2015) Effect of thyroid volume on radioiodine therapy outcome in hyperthyroid cats. J Feline Med Surg 18(2): 144–149

    Article  PubMed  Google Scholar 

  • Voorhout G, Stolp R, Rijnberk A, van Waes PF (1990) Assessment of survey radiography and comparison with x-ray computed tomography for detection of hyperfunctioning adrenocortical tumors in dogs. J Am Vet Med Assoc 196: 1799–1803

    CAS  PubMed  Google Scholar 

  • Wagner RA, Piche CA, Jochle W, Oliver JW (2005) Clinical and endocrine responses to treatment with deslorelin acetate implants in ferrets with adrenocortical disease.. Am J Vet Res 66: 910–914

    Article  CAS  PubMed  Google Scholar 

  • Weiss CA, Scott MV (1997) Clinical aspects and surgical treatment of hyperadrenocorticism in the domestic ferret: 94 cases (1994–1996). J Am Anim Hosp Assoc 33: 487–493

    Article  CAS  PubMed  Google Scholar 

  • Weiss CA, Williams BH, Scott MV (1998) Insulinoma in the ferret: clinical findings and treatment comparison of 66 cases. J Am Anim Hosp Assoc 34: 471–475

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut für Tierpathologie, Freie Universität Berlin, Berlin, Deutschland

    Robert Klopfleisch

Authors
  1. Robert Klopfleisch
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institut für Tierpathologie, Freie Universität Berlin, Berlin, Germany

    Robert Klopfleisch

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer-Verlag GmbH Deutschland

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Klopfleisch, R. (2017). Endokrine Tumoren. In: Klopfleisch, R. (eds) Veterinäronkologie kompakt. Springer Spektrum, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54987-2_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-54987-2_12

  • Published:

  • Publisher Name: Springer Spektrum, Berlin, Heidelberg

  • Print ISBN: 978-3-662-54986-5

  • Online ISBN: 978-3-662-54987-2

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation