Zusammenfassung
Mit zunehmendem Wissen über die molekularen Mechanismen der Tumorstehung (Karzinogenese) wird immer klarer, dass es sich dabei um einen hochkomplexen Prozess handelt. Diese Komplexität wird noch dadurch erhöht, dass die Karzinogenese sich bei verschiedenen Patienten unterscheidet und somit auch ein sehr individueller, für jeden Tumor einzigartiger Prozess ist.
Weiterführende Literatur
Argiles JM, Busquets S, Stemmler B, Lopez-Soriano FJ (2014) Cancer cachexia: understanding the molecular basis. Nature reviews. Cancer 14:754–762
Bergman PJ (2012) Paraneoplastic hypercalcemia. Top Compan Anim Med 27:156–158
Cancer Genome Atlas Network (2012a) Comprehensive molecular portraits of human breast tumours. Nature 490(7418):61–70
Cancer Genome Atlas Network (2012b) Comprehensive genomic characterization of squamous cell lung cancers. Nature 489(7417):519–525
Cancer Genome Atlas Network (2012c) Comprehensive molecular characterization of human colon and rectal cancer. Nature 487(7407):330–337
Cancer Genome Atlas Network, Weinstein JN, Collisson EA, Mills GB, Shaw KR, Ozenberger BA, Ellrott K, Shmulevich I, Sander C, Stuart JM (2013) The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet 45(10):1113–1120
Da Costa A, Oliveira JT, Gartner F, Kohn B, Gruber AD, Klopfleisch R (2011) Potential markers for detection of circulating canine mammary tumor cells in the peripheral blood. Vet J 190:165–168
Da Costa A, Lenze D, Hummel M, Kohn B, Gruber AD, Klopfleisch R (2012) Identification of six potential markers for the detection of circulating canine mammary tumour cells in the peripheral blood identified by microarray analysis. J Comp Pathol 146(2–3):143–151
Da Costa A, Kohn B, Gruber AD, Klopfleisch R (2013) Multiple RT-PCR markers for the detection of circulating tumour cells of metastatic canine mammary tumours. Vet J 196(1):34–39
Freeman LM (2012) Cachexia and sarcopenia: emerging syndromes of importance in dogs and cats. J Vet Intern Med/Am Coll Vet Intern Med 26:3–17
Greaves M, Maley CC (2012) Clonal evolution in cancer. Nature 481:306–313
Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646–674
Jiang WG, Sanders AJ, Katoh M, Ungefroren H, Gieseler F, Prince M, Thompson SK, Zollo M, Spano D, Dhawan P, Sliva D, Subbarayan PR, Sarkar M, Honoki K, Fujii H, Georgakilas AG, Amedei A, Niccolai E, Amin A, Ashraf SS, Ye L, Helferich WG, Yang X, Boosani CS, Guha G, Ciriolo MR, Aquilano K, Chen S, Azmi AS, Keith WN, Bilsland A, Bhakta D, Halicka D, Nowsheen S, Pantano F, Santini D (2015) Tissue invasion and metastasis: molecular, biological and clinical perspectives. Semin Cancer Biol 35:S244–S275
Jones S, Chen WD, Parmigiani G, Diehl F, Beerenwinkel N, Antal T, Traulsen A, Nowak MA, Siegel C, Velculescu VE et al (2008) Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci U S A 105(11):4283–4288
Kandoth C, McLellan MD, Vandin F, Ye K, Niu B, Lu C, Xie M, Zhang Q, McMichael JF, Wyczalkowski MA et al (2013) Mutational landscape and significance across 12 major cancer types. Nature 502(7471):333–339
Klopfleisch R, Lenze D, Hummel M, Gruber AD (2010) Metastatic canine mammary carcinomas can be identified by a gene expression profile that partly overlaps with human breast cancer profiles. BMC Cancer 10:618
Klopfleisch R, Lenze D, Hummel M, Gruber AD (2011) The metastatic cascade is reflected in the transcriptome of metastatic canine mammary carcinomas. Vet J 190(2):236–243
Klopfleisch R, Meyer A, Schlieben P, Bondzio A, Weise C, Lenze D, Hummel M, Einspanier R, Gruber AD (2012) Transcriptome and proteome analysis of tyrosine kinase inhibitor treated canine mast cell tumour cells identifies potentially kit signaling-dependent genes. BMC Vet Res 8:96
Klopfleisch R (2013) Personalized medicine in veterinary oncology: minimal residual disease and circulating tumour cells in dogs. Vet J 195(3):263–264
Klopfleisch R (2015) Personalised medicine in veterinary oncology: one to cure just one. Vet J 205(2):128–135
Klose P, Weise C, Bondzio A, Multhaup G, Einspanier R, Gruber AD, Klopfleisch R (2011) Is there a malignant progression associated with a linear change in protein expression levels from normal canine mammary gland to metastatic mammary tumors? J Proteome Res 10(10):4405–4415
Meyer A, Gruber AD, Klopfleisch R (2013) All subunits of the interleukin-2 receptor are expressed by canine cutaneous mast cell tumours. J Comp Pathol 149:19–29
Nowell PC (1976) The clonal evolution of tumor cell populations. Science 194:23–28
Pang LY, Argyle DJ (2014) The evolving cancer stem cell paradigm: implications in veterinary oncology. Vet J 205:154–160
Ressel L, Millanta F, Caleri E, Innocenti VM, Poli A (2009) Reduced PTEN protein expression and its prognostic implications in canine and feline mammary tumors. Vet Pathol 46:860–868
Turek MM (2003) Cutaneous paraneoplastic syndromes in dogs and cats: a review of the literature. Vet Dermatol 14:279–296
Vander Heiden MG, Cantley LC, Thompson CB (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324:1029–1033
Vogelstein B, Papadopoulos N, Velculescu VE, Zhou S, Diaz LA Jr, Kinzler KW (2013) Cancer genome landscapes. Science 339(6127):1546–1558
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Klopfleisch, R. (2017). Grundprinzipien der Tumorstehung. In: Klopfleisch, R. (eds) Veterinäronkologie kompakt. Springer Spektrum, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54987-2_1
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