Skip to main content

Krebs und Nährstoffsupplemente

  • Chapter
  • First Online:
Ernährung und Fasten als Therapie
  • 12k Accesses

Zusammenfassung

Weltweit erkranken jährlich etwa 14 Millionen Menschen neu an Krebs, von denen über 8 Millionen sterben. Damit steht Krebs mit gut 20 % aller Todesfälle nach Herz-Kreislauf-Erkrankungen an zweiter Stelle der Todesstatistik. In epidemiologischen Studien zeigte sich, dass bestimmte Krebsarten eine deutlich verminderte Inzidenz bei einem hohen Konsum bestimmter Nährstoffe und entsprechend hohen Serumkonzentrationen aufweisen. In der Prävention zeigen sich Nährstoffsupplemente allgemein als wirkungslos, in der Therapie von Krebskranken führen sie zu einer verbesserten Lebensqualität und gelten auch in hohen Dosierungen als sicher. Es fehlen große, kontrollierte Interventionsstudien bezüglich präventiver Wirkungen.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

Literatur

  • Albanes D, Heinonen OP, Taylor PR et al.: Alpha-tocopherol and beta-carotene supplements and lung cancer incidence in the alpha-tocopherol, beta-carotene cancer prevention study: effects of base-line characteristics and study compliance. J Natl Cancer Inst 88(21): 1560–1570 (1996)

    Article  CAS  Google Scholar 

  • Alfano CM, Imayama I, Neuhouser ML et al.: Fatigue, inflammation, and ω-3 and ω-6 fatty acid intake among breast cancer survivors. J Clin Oncol 30(12): 1280–1287 (2012)

    Article  CAS  Google Scholar 

  • Bjelakovic G, Gluud LL, Nikolova D et al.: Vitamin D supplementation for prevention of cancer in adults. Cochrane Database Syst Rev (6): CD007469 (2014)

    Google Scholar 

  • Burgerstein UP, Schurgast H, Zimmermann MG: Burgerstein Handbuch Nährstoffe. 12. Aufl. TRIAS-Verlag, Stuttgart (2012)

    Google Scholar 

  • Chen GC, Zhang ZL, Wan Z et al.: Circulating 25-hydroxyvitamin D and risk of lung cancer: a dose-response meta-analysis. Cancer Causes Control 26(12): 1719–1728 (2015a)

    Article  CAS  Google Scholar 

  • Chen GC, Qin LQ, Lu DB et al.: N-3 polyunsaturated fatty acids intake and risk of colorectal cancer: meta-analysis of prospective studies. Cancer Causes Control 26(1): 133–141 (2015b)

    Article  Google Scholar 

  • Clarke R, Halsey J, Lewington S et al.: B-vitamin treatment trialists' collaboration: effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: meta-analysis of 8 randomized trials involving 37 485 individuals. Arch Intern Med 170(18): 1622–1631 (2010)

    Article  CAS  Google Scholar 

  • Consolo LZ, Melnikov P, Cônsolo FZ et al.: Zinc supplementation in children and adolescents with acute leukemia. Eur J Clin Nutr 67(10): 1056–1059 (2013)

    Article  CAS  Google Scholar 

  • Coulter ID, Hardy ML, Morton SC et al.: Antioxidants vitamin C and vitamin E for the prevention and treatment of cancer. J Gen Intern Med 21(7): 735–744 (2006)

    Article  Google Scholar 

  • Duffield-Lillico AJ, Reid ME, Rurnbull BW et al.: Baseline characteristics and the effect of selenium supplementation on cancer incidence in a randomized clinical trial: a summary report of the Nutritional Prevention of Cancer Trial. Cancer Epidemiol Biomarkers Prev (2002)

    Google Scholar 

  • Fritz H, Flower G, Weeks L et al.: Intravenous vitamin C and cancer: A systematic review. Integr Cancer Ther 13(4): 280–300 (2014)

    Article  CAS  Google Scholar 

  • Gao M, Sun K, Guo M et al.: Fish consumption and n-3 polyunsaturated fatty acids, and risk of hepatocellular carcinoma: systematic review and meta-analysis. Cancer Causes Control 26(3): 367–76 (2015)

    Article  Google Scholar 

  • Gumulec J, Masarik M, Adam V et al.: Serum and tissue zinc in epithelial malignancies: a meta-analysis. PLoS One 9(6): e99790 (2014)

    Article  Google Scholar 

  • Harris HR, Orsini N, Wolk A: Vitamin C and survival among women with breast cancer: a meta-analysis. Eur J Cance r 50(7): 1223–1231 (2014)

    Article  CAS  Google Scholar 

  • Hu F, Wu Z, Li G et al.: The plasma level of retinol, vitamins A, C and α-tocopherol could reduce breast cancer risk? A meta-analysis and meta-regression. J Cancer Res Clin Oncol 601–614 (2015)

    Article  Google Scholar 

  • Huang RX, Duan YY, Hu JA: Fish intake and risk of liver cancer: a meta-analysis. PLoS One 10(1): e0096102 (2015)

    Article  Google Scholar 

  • Keum N, Giovannucci E: Vitamin D supplements and cancer incidence and mortality: a meta-analysis. Br J Cancer 111(5): 976–980 (2014)

    Article  CAS  Google Scholar 

  • Kong P, Cai Q, Geng Q et al.: Vitamin intake reduces the risk of gastric cancer: meta-analysis and systematic review of randomized and observational studies. PLoS One 9(12): e116060 (2014)

    Article  Google Scholar 

  • Lee EH, Myung SK, Jeon YJ et al.: Effects of selenium supplements on cancer prevention: meta-analysis of randomized controlled trials. Nutr Cancer 63(8): 1185–1195 (2011)

    Article  CAS  Google Scholar 

  • Li P, Xu J, Shi Y et al.: Association between zinc intake and risk of digestive tract cancers: a systematic review and meta-analysis. Clin Nutr 33(3): 415–420 (2014)

    Article  CAS  Google Scholar 

  • Lim ST, Jeon YW, Suh YJ: Association between alterations in the serum 25-hydroxyvitamin d status during follow-up and breast cancer patient prognosis. Asian Pac J Cancer Prev 16(6): 2507–2513 (2015)

    Article  Google Scholar 

  • Lin YS, Lin LC, Lin SW: Effects of zinc supplementation on the survival of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow-up of a double-blind randomized study with subgroup analysis. Laryngoscope 119(7): 1348–1352 (2009)

    Article  CAS  Google Scholar 

  • Lippman SM, Klein EA, Goodman PJ et al.: Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA 301(1): 39–51 (2009)

    Article  CAS  Google Scholar 

  • Luo J, Shen L, Zheng D: Association between vitamin C intake and lung cancer: a dose-response meta-analysis. Sci Rep 4: 6161 (2014)

    Article  CAS  Google Scholar 

  • Manson JE, Bassuk SS, Lee IM et al.: rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease. Contemp Clin Trials 33(1): 159–171 (2012)

    Article  CAS  Google Scholar 

  • Mayland CR, Bennett MI, Allan K et al.: Vitamin C deficiency in cancer patients. Palliat Med 19(1): 17–20 (2005)

    Article  Google Scholar 

  • Murphy RA, Mourtzakis M, Chu Q, Baracos VE, Reiman T, Mazurak VC: Supplementation with fish oil increases first-line chemotherapy efficacy in patients with advanced nonsmall cell lung cancer. Cancer 117(16): 3774–3780 (2011)

    Article  CAS  Google Scholar 

  • Noel SE, Stoneham AC, Olsen CM et al.: Consumption of omega-3 fatty acids and the risk of skin cancers: a systematic review and meta-analysis. Int J Cancer 135(1): 149–156 (2014)

    Article  CAS  Google Scholar 

  • PDQ Integrative, Alternative, and Complementary Therapies Editorial Board: High-Dose Vitamin C (PDQ®). National Cancer Institute, Bethesda, MD (2016)

    Google Scholar 

  • Qiao L, Feng Y: Intakes of heme iron and zinc and colorectal cancer incidence: a meta-analysis of prospective studies. Cancer Causes Control 24(6): 1175–1183 (2013)

    Article  Google Scholar 

  • Qin X, Cui Y, Shen L et al.: Folic acid supplementation and cancer risk: a meta-analysis of randomized controlled trials. Int J Cancer 133(5): 1033–1041 (2013)

    Article  CAS  Google Scholar 

  • Schmiedel V: Quickstart Nährstofftherapie. Hippokrates, Stuttgart (2010)

    Google Scholar 

  • Schöttker B, Jorde R, Peasey A et al.:Consortium on Health and Ageing: Network of Cohorts in Europe and the United States: Vitamin D and mortality: meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United States. BMJ 348: g3656 (2014)

    Article  Google Scholar 

  • Sieja K, Talerczyk M: Selenium as an element in the treatment of ovarian cancer in women receiving chemotherapy. Gynecologic Oncology 93(2): 320–327 (2004)

    Article  CAS  Google Scholar 

  • Tang JE, Wang RJ, Zhong H et al.: Vitamin A and risk of bladder cancer: a meta-analysis of epidemiological studies. World J Surg Oncol 12: 130 (2014)

    Article  Google Scholar 

  • Tumorzentrum München: Nahrungsergänzungsmittel. Nahrungsergänzungsmittel und Krebs. http://www.ernaehrung-krebs-tzm.de/ernaehrung-krebs/nahrungsergaenzungs-mittel.html (2015)

  • Vinceti M, Dennert G, Crespi CM et al.: Selenium for preventing cancer. Cochrane Database Syst Rev 10(3): CD005195 (2014)

    Google Scholar 

  • Wang W, Li G, He X et al.: Serum 25-hydroxyvitamin D levels and prognosis in hematological malignancies: a systematic review and meta-analysis. Cell Physiol Biochem 35(5): 1999–2005 (2015)

    Article  CAS  Google Scholar 

  • Wu Y, Ye Y, Shi Y et al.: Association between vitamin A, retinol intake and blood retinol level and gastric cancer risk: A meta-analysis. Clin Nutr 34(4): 620–626 (2015)

    Article  CAS  Google Scholar 

  • Xu X, Yu E, Liu L et al.: Dietary intake of vitamins A, C, and E and the risk of colorectal adenoma: a meta-analysis of observational studies. Eur J Cancer Prev (2013)

    Google Scholar 

  • Yang B, Wang FL, Ren XL, Li D: Biospecimen long-chain N-3 PUFA and risk of colorectal cancer: a meta-analysis of data from 60,627 individuals. PLoS One 9(11): e110574 (2014a)

    Article  Google Scholar 

  • Yang B, Ren XL, Fu YQ, Gao JL, Li D: Ratio of n-3/n-6 PUFAs and risk of breast cancer: a meta-analysis of 274135 adult females from 11 independent prospective studies. BMJ Cancer 14 : 105 (2014b)

    Article  CAS  Google Scholar 

  • Zhang D, Wen X, Wu W et al.: Elevated homocysteine level and folate deficiency associated with increased overall risk of carcinogenesis: meta-analysis of 83 case-control studies involving 35,758 individuals. PLoS One 10(5): e0123423 (2015)

    Article  Google Scholar 

  • Zhang YP, Chu RX, Liu H: Vitamin A intake and risk of melanoma: a meta-analysis. PLoS One 9(7): e102527 (2014)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer-Verlag GmbH Deutschland

About this chapter

Cite this chapter

Schmiedel, V. (2018). Krebs und Nährstoffsupplemente. In: Stange, R., Leitzmann, C. (eds) Ernährung und Fasten als Therapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54475-4_22

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-54475-4_22

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-54474-7

  • Online ISBN: 978-3-662-54475-4

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics