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Biomimic Design of Periosteum: Construction Strategies, Scaffold Design and Cell Sources

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Biomaterials for Implants and Scaffolds

Part of the book series: Springer Series in Biomaterials Science and Engineering ((SSBSE,volume 8))

Abstract

In terms of bone physiology, the periosteum plays critical roles in both bone formation and defect healing. Periosteum is a dual-layered soft tissue membrane that contains osteogenic progenitor cells in the cambial layer, as well as blood supply and supportive cells in the fibrous layer. Transplantation of autogenous or allogenous periosteum has been applied successfully in the repair of various-sized bone defects, especially in large bone defects. However, two major concerns exist in relation to the insufficient autologous donor tissues and donor site morbidity or immunological rejection related to allogeneic tissues. Periosteum tissue engineering is to mimic the natural structure of periosteum, which will guide bone formation in a physiological manner. This chapter provides current information about the construction strategies, scaffold design and cell sources for the periosteum tissue engineering based on the structure and functions of natural periosteum.

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Authors and Affiliations

  1. Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, 4059, Australia

    Yin Xiao, Ross Crawford & Dietmar W. Hutmacher

  2. School of Stomatology, Wuhan University, Hubei, China

    Wei Fan

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  1. Yin Xiao
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  2. Wei Fan
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  3. Ross Crawford
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  4. Dietmar W. Hutmacher
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Correspondence to Yin Xiao .

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Editors and Affiliations

  1. School of Aerospace, Mechanical & Mechatronic Engineering, The University of Sydney, Sydney, New South Wales, Australia

    Qing Li

  2. School of Aerospace, Mechanical & Mechatronic Engineering, The University of Sydney, Sydney, New South Wales, Australia

    Yiu-Wing Mai

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Xiao, Y., Fan, W., Crawford, R., Hutmacher, D.W. (2017). Biomimic Design of Periosteum: Construction Strategies, Scaffold Design and Cell Sources. In: Li, Q., Mai, YW. (eds) Biomaterials for Implants and Scaffolds. Springer Series in Biomaterials Science and Engineering, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-53574-5_10

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