Zusammenfassung
Das Frühgeburtsrisiko ist bei Mehrlingen gegenüber Einlingen erhöht. Die Vorhersage einer Frühgeburt bei einer Mehrlingsschwangerschaft ist kaum möglich. Bekannte Maßnahmen zur Prävention oder Hemmung der Wehentätigkeit wie z.B. Progesteron, Bettruhe, Cerclage und tokolytische Therapie reduzieren die Frühgeburtenrate bei Mehrlingsschwangerschaften nicht. Durch eine selektive Mehrlingsreduktion sollen bei höhergradigen Mehrlingsschwangerschaften Risiken für die Mutter und die verbleibenden Feten vermindert werden. Der selektive Fetozid ist ethisch allerdings äußerst problematisch.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Literatur
Abdul Sultan A, West J, Tata LJ, Fleming KM, Nelson-Piercy C, Grainge MJ (2013) Risk of first venous thromboembolism in pregnant women in hospital: population based cohort study from England. BMJ 347: f6099
Abele H, Berger R, Garnier Y, Kuon R, Maul H, Mylonas I, Rath W, Schleußner E (2015) Frauenarzt 56(10): 866–876
ACOG Committee Opinion (2007) Multifetal pregnancy reduction. Obstet Gynecol 109: 1511–1515
Ballabh P, Kumari J, AlKouatly HB, Yih M, Arevalo R, Rosenwaks Z, Krauss AN (2003) Neonatal outcome of triplet versus twin and singleton pregnancies: a matched case control study. Eur J Obstet Gynecol Reprod Biol 107(1): 28
Barton SE, Missmer SA, Hornstein MD (2011) Twin pregnancies with a ‚vanished’ embryo: a higher risk multiple gestation group? Hum Reprod 26 (10): 2750
Berger R, Abele H, Garnier Y, Kuon R, Rath W, Schleussner E, Maul H (2014) Prävention der Frühgeburt mit Zerklage oder totalem Muttermundsverschluss. Frauenarzt 55(10): 966–974
Berghella V, Odibo AO, To MS, Rust OA, Althuisius SM (2005) Cerclage for short cervix on ultrasonography: meta-analysis of trials using individual patient-level data. Obstet Gynecol 106(1): 181–189
Berkowitz RL, Lynch L, Lapinski R, Berger P (1993) First-trimester transabdominal multifetal pregnancy reduction: a report of two hundred completed cases. Am J Obstet Gynecol 169: 17–21
Bianco AT, Stone J, Lapinski R, Lockwood C, Lynch L, Berkowitz RL (1996) The clinical outcome of preterm premature rupture of membranes in twin versus singleton pregnancies. Am J Perinatol 13(3): 135–138
Caritis SN, Rouse DJ, Peaceman AM, Sciscione A, Momirova V, Spong CY, Iams JD, Wapner RJ, Varner M, Carpenter M, Lo J, Thorp J, Mercer BM, Sorokin Y, Harper M, Ramin S, Anderson G; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Maternal-Fetal Medicine Units Network (MFMU) (2009) Prevention of preterm birth in triplets using 17 alpha-hydroxyprogesterone caproate: a randomized controlled trial. Obstet Gynecol 113(2 Pt1): 285–292
Carlson NJ, Towers C (1989) Multiple gestation complicated by the death of one fetus. Obstet Gynecol 73: 685
Chasen ST, Chervenak FA (2016) Twin pregnancy: prenatal issues. UpToDate-Online-Review (Stand 03/2016, http://www.uptodate.com/contents/twin-pregnancy-prenatal-issues?source=search_result&search=twin+preterm+birth&selectedTitle=1%7E150)
Combs CA, Garite T, Maurel K, Das A, Porto M; Obstetrix Collaborative Research Network (2010) Failure of 17-hydroxyprogesterone to reduce neonatal morbidity or prolong triplet pregnancy: a double-blind, randomized clinical trial. Am J Obstet Gynecol 203(3): 248.e1–9
Conde-Agudelo A, Romero R, Hassan SS, Yeo L (2010) Transvaginal sonographic cervical length for the prediction of spontaneous preterm birth in twin pregnancies: a systematic review and metaanalysis. Am J Obstet Gynecol 203(2): 128.e1
Crowther CA, Han S (2010) Hospitalisation and bed rest for multiple pregnancy. Cochrane Database Syst Rev 7: CD000110. doi: 10.1002/14651858.CD000110.pub2
Dailey TL, Jayakrishnan A, Phipps M, Raker CA, Chien EK (2009) The contribution of maternal race/ethnicity and fetal sex to prematurity in twins. Am J Obstet Gynecol 201(1): 68.e1
Dudenhausen JW, Maier RF (2010) Perinatale Probleme von Mehrlingen. Dtsch Ärztebl Int 107(38): 663–668
Durnwald CP (2013) 17 OHPC for prevention of preterm birth in twins: back to the drawing board? Am J Obstet Gynecol 208(3): 167–168
Gibson JL, Macara LM, Owen P, Young D, Macauley J, Mackenzie F (2004) Prediction of preterm delivery in twin pregnancy: a prospective, observational study of cervical length and fetal fibronectin testing. Ultrasound Obstet Gynecol 23(6): 561
Goldenberg RL, Iams JD, Miodovnik M, Van Dorsten JP, Thurnau G, Bottoms S, Mercer BM, Meis PJ, Moawad AH, Das A, Caritis SN, McNellis D (1996) The preterm prediction study: risk factors in twin gestations. Am J Obstet Gynecol 175(4 Pt 1): 1047–1053
Goya M, de la Calle M, Pratcorona L, Merced C, Rodó C, Muñoz B, Juan M, Serrano A, Llurba E, Higueras T, Carreras E, Cabero L; PECEP-Twins Trial Group (2016) Cervical pessary to prevent preterm birth in women with twin gestation and sonographic short cervix: a multicenter randomized controlled trial (PECEP-Twins). Am J Obstet Gynecol 214(2): 145–152
Guzman ER, Walters C, O’reilly-Green C, Kinzler WL, Waldron R, Nigam J, Vintzileos AM (2000) Use of cervical ultrasonography in prediction of spontaneous preterm birth in twin gestations. Am J Obstet Gynecol 183(5): 1103–1107
Hamilton BE, Martin JA, Osterman MJ, Curtin SC, Matthews TJ (2015) Births: final data for 2014. Natl Vital Stat Rep 64(12): 1–64
Jacquemyn Y, Martens G, Ruyssinck G, Michiels I, Van Overmeire B (2003) A matched cohort comparison of the outcome of twin versus singleton pregnancies in Flanders, Belgium. Twin Res 6(1): 7
Jacquemyn Y, Noelmans L, Mahieu L, Buytaert P (2003) Twin versus singleton pregnancy and preterm prelabour rupture of the membranes. Clin Exp Obstet Gynecol 30(2-3): 99–102
Lim AC, Hegeman MA, Huis In T‘Veld MA, Opmeer BC, Bruinse HW, Mol BW (2011) Cervical length measurement for the prediction of preterm birth in multiple pregnancies: a systematic review and bivariate meta-analysis. Ultrasound Obstet Gynecol 38 (1):10
Liem S, Schuit E, Hegeman M, Bais J, de Boer K, Bloemenkamp K, Brons J, Duvekot H, Bijvank BN, Franssen M, Gaugler I, de Graaf I, Oudijk M, Papatsonis D, Pernet P, Porath M, Scheepers L, Sikkema M, Sporken J, Visser H, van Wijngaarden W, Woiski M, van Pampus M, Mol BW, Bekedam D (2013) Cervical pessaries for prevention of preterm birth in women with a multiple pregnancy (ProTWIN): a multicentre, open-label randomised controlled trial. Lancet 382(9901): 1341–1349
Ludwig M, Kohl M, Krüger A et al. (2004) Komplikationen bei höhergradigen Mehrlingsschwangerschaften für Mütter und Kinder. Geburtsh Frauenheilk 64: 168–177
Lyall F, Lye S, Teoh T, Cousins F, Milligan G, Robson S (2002) Expression of Gsalpha, connexin-43, and EP1, 3, and 4 receptors in myometrium of prelabor singleton versus multiple gestations and the effects of mechanical stretch and steroids on Gsalpha. J Soc Gynecon Investig 9(5): 299–307
Maul H, Schröder W (2001) Selektiver Fetozid und Reduktion von Mehrlingsschwangerschaften. In: Schröder W Mehrlingsschwangerschaft und Mehrlingsgeburt. Thieme, Stuttgart
Melamed N, Yogev Y, Glezerman M (2009) Effect of fetal sex on pregnancy outcome in twin pregnancies. Obstet Gynecol 114(5): 1085
Mercer BM, Crocker LG, Pierce WF, Sibai BM (1993) Clinical characteristics and outcome of twin gestation complicated by preterm premature rupture of the membranes. Am J Obstet Gynecol 168(5): 1467–1473
Miller ES, Rajan PV, Grobman WA (2014) Outcomes after physical examination-indicated cerclage in twin gestations. Am J Obstet Gynecol 211(1): 46.e1–5
Murphy DJ, Caukwell S, Joels LA, Wardle P (2002) Cohort study of the neonatal outcome of twin pregnancies that were treated with prophylactic or rescue antenatal corticosteroids. Am J Obstet Gynecol 187(2): 483–488
Nicolaides KH, Syngelaki A, Poon LC, de Paco Matallana C, Plasencia W, Molina FS, Picciarelli G, Tul N, Celik E, Lau TK, Conturso R (2016) Cervical pessary placement for prevention of preterm birth in unselected twin pregnancies: a randomized controlled trial. Am J Obstet Gynecol 214(1): 3.e1–9
Rafael TJ, Berghella V, Alfirevic Z (2014) Cervical stitch (cerclage) for preventing preterm birth in multiple pregnancy. Cochrane Database Syst Rev 9: CD009166
Rebarber A, Bender S, Silverstein M, Saltzman DH, Klauser CK, Fox NS (2014) Outcomes of emergency or physical examination-indicated cerclage in twin pregnancies compared to singleton pregnancies. Eur J Obstet Gynecol Reprod Biol 173: 43–47
Roman A, Rochelson B, Fox NS, Hoffman M, Berghella V, Patel V, Calluzzo I, Saccone G, Fleischer A (2015) Efficacy of ultrasound-indicated cerclage in twin pregnancies. Am J Obstet Gynecol 212(6): 788.e1–6
Schuit E, Stock S, Rode L, Rouse Dj, Lim A, Norman J, Nassar A, Serra V, Combs C, Vayssiere C, Aboulghar M, Wood S,Çetingöz E, Briery C, Fonseca E, Worda K, Tabor A, Thom E, Caritis S, Awwad J, Usta I, Perales A, Meseguer J, Maurel K, Garite T, Aboulghar M, Amin Y, Ross S, Cam C, Karateke A, Morrison J, Magann E, Nicolaides Kh, Zuithoff N, Groenwold R, Moons K, Kwee A, Mol B, Global Obstetrics Network (GONet) collaboration (2015) Effectiveness of progestogens to improve perinatal outcome in twin pregnancies: an individual participant data meta-analysis. BJOG 122(1): 27
Sciscione AC (2010) Maternal activity restriction and the prevention of preterm birth. Am J Obstet Gynecol 202(3): 232.e1
Senat MV, Porcher R, Winer N, Vayssière C, Deruelle P, Capelle M, Bretelle F, Perrotin F, Laurent Y, Connan L, Langer B, Mantel A, Azimi S, Rozenberg P; Groupe de Recherche en Obstétrique et Gynécologie (2013) Prevention of preterm delivery by 17 alpha-hydroxyprogesterone caproate in asymptomatic twin pregnancies with a short cervix: a randomized controlled trial. Am J Obstet Gynecol 208(3): 194.e1–8
Serra V, Perales A, Meseguer J, Parrilla JJ, Lara C, Bellver J, Grifol R, Alcover I, Sala M, Martínez-Escoriza JC, Pellicer A (2013) Increased doses of vaginal progesterone for the prevention of preterm birth in twin pregnancies: a randomised controlled double-blind multicentre trial. BJOG 120(1): 50–57
Singer E, Pilpel S, Bsat F, Plevyak M, Healy A, Markenson G (2007) Accuracy of fetal fibronectin to predict preterm birth in twin gestations with symptoms of labor. Obstet Gynecol 109(5): 1083
Sotiriadis A, Papatheodorou S, Makrydimas G (2012) Perinatal outcome in women treated with progesterone for the prevention of preterm birth: a meta-analysis. Ultrasound Obstet Gynecol 40(3): 257–266
Tan H, Wen SW, Walker M, Fung KF, Demissie K, Rhoads GG, Mark W (2004) The association between fetal sex and preterm birth in twin pregnancies. Obstet Gynecol 103(2): 327
Trentacoste SV, Jean-Pierre C, Baergen R, Chasen ST (2008) Outcomes of preterm premature rupture of membranes in twin pregnancies. J Matern Fetal Neonatal Med 21(8): 555–557
Turton A, Arrowsmith S, Prescott J, Ballard C, Bricker L, Neilson J, Wray S (2013) A comparison of the contractile properties of myometrium from singleton and twin pregnancies. PLoS One 8(5): e63800
Vayssière C, Favre R, Audibert F, Chauvet MP, Gaucherand P, Tardif D, Grangé G, Novoa A, Descamps P, Perdu M, Andrini E, Janse-Marec J, Maillard F, Nisand I (2002) Cervical length and funneling at 22 and 27 weeks to predict spontaneous birth before 32 weeks in twin pregnancies: a French prospective multicenter study. Am J Obstet Gynecol 187: 1596
Yamasmit W, Chaithongwongwatthana S, Tolosa JE, Limpongsanurak S, Pereira L, Lumbiganon P (2015) Prophylactic oral betamimetics for reducing preterm birth in women with a twin pregnancy. Cochrane Database Syst Rev 12: CD004733
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Maul, H. (2017). Besonderheiten der Frühgeburtsprävention bei Zwillingen und höhergradigen Mehrlingen inklusive selektiver Mehrlingsreduktion. In: Toth, B. (eds) Fehlgeburten Totgeburten Frühgeburten. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-50424-6_30
Download citation
DOI: https://doi.org/10.1007/978-3-662-50424-6_30
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-50423-9
Online ISBN: 978-3-662-50424-6
eBook Packages: Medicine (German Language)