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Die fetomaternale Grenzzone

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Fehlgeburten Totgeburten Frühgeburten

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Zusammenfassung

Die Organismen von Mutter und Fetus werden während der Schwangerschaft durch die fetale Grenzschicht voneinander getrennt. Es wird beschrieben, wie sich diese Grenzschicht auf zellulärer Ebene herausbildet, wobei insbesondere auf Plazentation, Plazenta, extravillöse Trophoblasten und trophoblastäre extrazelluläre Vesikel eingegangen wird. Von der Interaktion von Trophoblastzellen und maternalen uterinen Immunzellen hängen Schwangerschaft und plazentare Entwicklung maßgeblich ab.

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Literatur

  • Abrahams VM et al. (2005) A role for TLRs in the regulation of immune cell migration by first trimester trophoblast cells. J Immunol 175(12): 8096–8104

    Article  CAS  PubMed  Google Scholar 

  • Armant DR (2005) Blastocysts don’t go it alone. Extrinsic signals fine-tune the intrinsic developmental program of trophoblast cells. Developmental Biology 280(2): 260–280

    CAS  PubMed  Google Scholar 

  • Benirschke K (2006) Pathology of the human placenta. Springer, New York

    Google Scholar 

  • Bulmer JN, Morrison L, Johnson PM (1988) Expression of the proliferation markers Ki67 and transferrin receptor by human trophoblast populations. J Reprod Immunol 14(3): 291–302

    Article  CAS  PubMed  Google Scholar 

  • Bulmer JN, Pace D, Ritson A (1988) Immunoregulatory cells in human decidua: morphology, immunohistochemistry and function. Reprod Nutr Dev 28(6B): 1599–1613

    Article  CAS  PubMed  Google Scholar 

  • Bulmer JN, Williams PJ, Lash GE (2010) Immune cells in the placental bed. Int J Dev Biol 54(2-3): 281–294

    Article  PubMed  Google Scholar 

  • Chamley LW et al. (2014) Review: where is the maternofetal interface? Placenta 35 (suppl): S74–80

    Article  Google Scholar 

  • Daya D, Sabet L (1991) The use of cytokeratin as a sensitive and reliable marker for trophoblastic tissue. Am J Clin Pathol 95(2): 137–141

    Article  CAS  PubMed  Google Scholar 

  • Delorme-Axford E et al. (2013) Human placental trophoblasts confer viral resistance to recipient cells. Proc Natl Acad Sci U S A 110(29): 12048–12053

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • De Wolf F, Brosens I, Renaer M (1980) Fetal growth retardation and the maternal arterial supply of the human placenta in the absence of sustained hypertension. Br J Obstet Gynaecol 87(8): 678–685

    Article  CAS  PubMed  Google Scholar 

  • Gardner L, Moffett A (2003) Dendritic cells in the human decidua. Biol Reprod 69(4): 1438–1446

    Article  CAS  PubMed  Google Scholar 

  • Gohner C et al. (2015) A new enzyme-linked sorbent assay (ELSA) to quantify syncytiotrophoblast extracellular vesicles in biological fluids. Am J Reprod Immunol 73(6): 582–588

    Article  PubMed  Google Scholar 

  • Haig D (1993) Genetic conflicts in human pregnancy. Quarterly Review of Biology 68(4): 495–532

    Article  CAS  PubMed  Google Scholar 

  • Houser BL (2012) Decidual macrophages and their roles at the maternal-fetal interface. Yale J Biol Med 85(1): 105–118

    CAS  PubMed  PubMed Central  Google Scholar 

  • Huppertz B (2008) Placental origins of preeclampsia - Challenging the current hypothesis. Hypertension 51(4): 970–975

    Article  CAS  PubMed  Google Scholar 

  • Kabawat, S.E., et al., Implantation site in normal pregnancy. A study with monoclonal antibodies. Am J Pathol, 1985. 118(1): p. 76–84.

    CAS  PubMed  Google Scholar 

  • Kammerer U, von Wolff M, Markert UR (2004) Immunology of human endometrium. Immunobiology 209(7): 569–574

    Article  PubMed  Google Scholar 

  • Kammerer U et al. (2000) Human decidua contains potent immunostimulatory CD83(+) dendritic cells. Am J Pathol 157(1): 159–169

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kaufmann P, Castelluci M (1997) Extravillous trophoblast in the human placenta. Trophoblast Research 10: 21–65

    Google Scholar 

  • Khong TY, Lane EB, Robertson WB (1986) An immunocytochemical study of fetal cells at the maternal-placental interface using monoclonal antibodies to keratins, vimentin and desmin. Cell Tissue Res 246(1): 189–195

    Article  CAS  PubMed  Google Scholar 

  • Labarrere CA, Althabe OH (1987) Inadequate maternal vascular response to placentation in pregnancies complicated by preeclampsia and by small-for-gestational-age infants. Br J Obstet Gynaecol 94(11): 1113–1116

    Article  CAS  PubMed  Google Scholar 

  • Lunghi L et al. (2007) Control of human trophoblast function. Reproductive Biology and Endocrinology 5

    Google Scholar 

  • Mincheva-Nilsson L et al. (1994) Immunomorphologic studies of human decidua-associated lymphoid cells in normal early pregnancy. J Immunol 152(4): 2020–2032

    CAS  PubMed  Google Scholar 

  • Moore KL, Persaud TVN (1996, 2007) Embryologie. Schattauer, Stuttgart

    Google Scholar 

  • Mor G (2008) Inflammation and pregnancy: the role of toll-like receptors in trophoblast-immune interaction. Ann N Y Acad Sci 1127: 121–128

    Article  CAS  PubMed  Google Scholar 

  • Mor G, Cardenas I (2010) The immune system in pregnancy: a unique complexity. Am J Reprod Immunol 63(6): 425–433

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mor G, Straszewski-Chavez SL, Abrahams VM (2006) Macrophage-trophoblast interactions. Methods Mol Med 122: 149–163

    PubMed  Google Scholar 

  • Morales-Prieto DM et al. (2014) Elsevier Trophoblast Research Award Lecture: origin, evolution and future of placenta miRNAs. Placenta 35(suppl): S39–45

    Google Scholar 

  • Ospina-Prieto S et al. (2016) MicroRNA-141 is upregulated in preeclamptic placentae and regulates trophoblast invasion and intercellular communication. Transl Res

    Google Scholar 

  • Redman CW, Sacks GP, Sargent IL (1999) Preeclampsia: an excessive maternal inflammatory response to pregnancy. Am J Obstet Gynecol 180(2 Pt 1): 499–506

    Article  CAS  PubMed  Google Scholar 

  • Salafia C, Shiverick K (1999) Cigarette smoking and pregnancy II: vascular effects. Placenta 20(4): 273–279

    Article  CAS  PubMed  Google Scholar 

  • Schmorl G (1893) Pathologisch-anatomische Untersuchungen über Puerperal-Eklampsie. Vogel

    Google Scholar 

  • Scipiades E, Burg E (1930) Über die Morphoiogie der menschlichen Placenta mit besonderer Rücksicht auf unsere eigenen Studien. Arch Gynecol, 577–619

    Google Scholar 

  • Seshadri S, Sunkara SK (2014) Natural killer cells in female infertility and recurrent miscarriage: a systematic review and meta-analysis. Hum Reprod Update 20(3): 429–438

    Article  PubMed  Google Scholar 

  • Shimada S et al. (2006) Natural killer, natural killer T, helper and cytotoxic T cells in the decidua from sporadic miscarriage. Am J Reprod Immunol 56(3): 193–200

    Article  CAS  PubMed  Google Scholar 

  • Trundley A, Moffett A (2004) Human uterine leukocytes and pregnancy. Tissue Antigens 63(1): 1–12

    Article  CAS  PubMed  Google Scholar 

  • Tuckerman E. et al. (2010) Uterine natural killer cells in peri-implantation endometrium from women with repeated implantation failure after IVF. J Reprod Immunol 87(1–2): 60–66

    Article  CAS  PubMed  Google Scholar 

  • VanWijk MJ et al. (2002) Microparticle subpopulations are increased in preeclampsia: possible involvement in vascular dysfunction? Am J Obstet Gynecol 187(2): 450–456

    Article  PubMed  Google Scholar 

  • Wira CR, Grant-Tschudy KS, Crane-Godreau MA (2005) Epithelial cells in the female reproductive tract: a central role as sentinels of immune protection. Am J Reprod Immunol 53(2): 65–76

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Klinik für Frauenheilkunde und Geburtshilfe- Abteilung für Geburtshilfe, Placentalabor Universität Jena, Bachstraße 18, 07743, Jena, Deutschland

    Udo R. Markert

  2. Klinik für Frauenheilkunde und Geburtshilfe Abteilung für Geburtshilfe, Placentalabor Universität Jena, Bachstraße 18, 07743, Jena, Deutschland

    Theresa Wagner

  3. Klinik für Frauenheilkunde und Geburtshilfe- Abteilung für Geburtshilfe, Placentalabor Jena, Bibliotheksweg 1, 07743, Jena, Deutschland

    Stephanie Biennek

  4. Praxis für Allgemeinmedizin, Ahornstraße 2a, 7549, Gera, Deutschland

    Sebastian Grosse

Authors
  1. Udo R. Markert
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  2. Theresa Wagner
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  3. Stephanie Biennek
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  4. Sebastian Grosse
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Editors and Affiliations

  1. Gynäkologische Endokrinologie und Reproduktionsmedizin, Medizinische Universität Innsbruck, Innsbruck, Austria

    Bettina Toth

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Markert, U.R., Wagner, T., Biennek, S., Grosse, S. (2017). Die fetomaternale Grenzzone. In: Toth, B. (eds) Fehlgeburten Totgeburten Frühgeburten. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-50424-6_3

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  • DOI: https://doi.org/10.1007/978-3-662-50424-6_3

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-50423-9

  • Online ISBN: 978-3-662-50424-6

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