Skip to main content

Fetale Programmierung

  • Chapter
  • First Online:
Fehlgeburten Totgeburten Frühgeburten
  • 4492 Accesses

  • Dieses Kapitel ist eine leicht modifizierte Version eines von den Autoren in der Fachzeitschrift „Bundesgesundheitsblatt – Gesundheitsforschung – Gesundheitsschutz“ publizierten Artikels (DOI 10.1007/s00103-014-2015-3), dessen Reproduktion durch den Verlag genehmigt wurde.

Zusammenfassung

Die Zunahme immunologischer und psychischer Erkrankungen in der Bevölkerung kann möglicherweise auf die pränatale Programmierung zurückgeführt werden. Wie Studien am Tiermodell und am Menschen zeigen, stehen mütterliche Umwelt und heranwachsender Fetus in Interaktion. Umwelteinflüsse (z.B. Stress, Hormone, Ernährung), die vor und während der Schwangerschaft ihre Wirkung entfalten, können die vorgeburtliche Entwicklung des Fetus im Hinblick auf ein späteres Krankheitsrisiko beeinflussen.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 64.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 84.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Notes

  1. 1.

    Deutsche Übersetzung: Jean-Baptiste de Lamarck (2002) Zoologische Philosophie. Deutsch Harri

Literatur

  • Andersson IJ, Jiang YY, Davidge ST (2009) Maternal stress and development of atherosclerosis in the adult apolipoprotein E-deficient mouse offspring. Am J Physiol Regul Integr Comp Physiol 296: R663–R671

    Article  Google Scholar 

  • Arck PC, Hecher K (2013) Fetomaternal immune cross-talk and its consequences for maternal and offspring’s health. Nat Med 19: 548–556

    Article  CAS  PubMed  Google Scholar 

  • Bach JF (2002) The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med 347: 911–920

    Article  PubMed  Google Scholar 

  • Barker DJ, Osmond C, Law CM (1989) The intrauterine and early postnatal origins of cardiovascular disease and chronic bronchitis. J Epidemiol Community Health 43: 237–240

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Barker DJ, Thornburg KL (2013) Placental programming of chronic diseases, cancer and lifespan: a review. Placenta 34: 841–845

    Article  CAS  PubMed  Google Scholar 

  • Beversdorf DQ, Manning SE, Hillier A, Anderson SL, Nordgren RE,Walters SE, Nagaraja HN, Cooley WC, Gaelic SE, Bauman ML (2005) Timing of prenatal stressors and autism. J Autism Dev Disord 35: 471–478

    Article  CAS  PubMed  Google Scholar 

  • Cottrell EC, Seckl JR (2009) Prenatal stress, glucocorticoids and the programming of adult disease. Front Behav Neurosci 3: 19

    Article  PubMed  PubMed Central  Google Scholar 

  • Darwin C (1859) On the origins of species by means of natural selection or the preservation of favoured races in the struggle for life. http://en.wikisource.org/wiki/The_Origin_of_Species_(1872) (Zugriff: 16.01.2014)

  • Epstein FH (1996) Cardiovascular disease epidemiology: a journey from the past into the future. Circulation 93: 1755–1764

    Article  CAS  PubMed  Google Scholar 

  • Forsdahl A (1977) Are poor living conditions in childhood and adolescence an important risk factor for arteriosclerotic heart disease? Br J Prev Soc Med 31: 91–95

    CAS  PubMed  Google Scholar 

  • Gale CR, Martyn CN (2004) Birth weight and later risk of depression in a national birth cohort. Br J Psychiatry 184: 28–33

    Article  PubMed  Google Scholar 

  • Gerardin P,Wendland J, Bodeau N, Galin A, Bialobos S, Tordjman S, Mazet P, Darbois Y, Nizard J, Dommergues M, Cohen D (2011) Depression during pregnancy: Is the developmental impact earlier in boys? a prospective case-control study. J Clin Psychiatry 72: 378–387

    Article  PubMed  Google Scholar 

  • Gilbert SF (2001) Ecological developmental biology: developmental biology meets the real world. Dev Biol 233: 1–12

    Article  CAS  PubMed  Google Scholar 

  • Gilbert SF (2002) The genome in its ecological context: philosophical perspectives on interspecies epigenesis. Ann N Y Acad Sci 981: 202–218

    Article  PubMed  Google Scholar 

  • Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, Dai S, Ford ES, Fox CS, Franco S, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Huffman MD, Judd SE, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Mackey RH, Magid DJ, Marcus GM, Marelli A, Matchar DB, McGuire DK, Mohler ER 3rd, Moy CS, Mussolino ME, Neumar RW, Nichol G, Pandey DK, Paynter NP, Reeves MJ, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Wong ND, Woo D, Turner MB; on behalf of the American Heart Association Statistics Committee and Stroke Statistics Subcommittee (2002) Heart disease and stroke statistics - 2014 update: a report from the American Heart Association. Circulation 129: e28–e292

    Google Scholar 

  • Gore AC (2008) Developmental programming and endocrine disruptor effects on reproductive neuroendocrine systems. Front Neuroendocrinol 29: 358–374

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hartwig IR, Pincus MK, Diemert A, Hecher K, Arck PC (2013) Sex-specific effect of first-trimester maternal progesterone on birthweight. Hum Reprod 28: 77–86

    Article  CAS  PubMed  Google Scholar 

  • Hartwig IR, Sly PD, Schmidt LA, van Lieshout R, Bienenstock J, Holt PG, Arck PC (2014) Prenatal adverse life events increase the risk for atopic diseases in children, which is enhanced in the absence of a maternal atopic predisposition. J All Clin Immunol (in press)

    Google Scholar 

  • Hemmings DG, Williams SJ, Davidge ST (2005) Increased myogenic tone in 7-month-old adult male but not female offspring from rat dams exposed to hypoxia during pregnancy. Am J Physiol Heart Circ Physiol 289: H674–H682

    Article  Google Scholar 

  • Hickey RJ, Clelland RC, Bowers EJ (1978) Maternal smoking, birth weight, infant death, and the self-selection problem. Am J Obstet Gynecol 131: 805–811

    Article  CAS  PubMed  Google Scholar 

  • Jaddoe VW, de Jonge LL, Hofman A, Franco OH, Steegers EA, Gaillard R (2014) First trimester fetal growth restriction and cardiovascular risk factors in school age children: population based cohort study. BMJ 348: g14

    Article  Google Scholar 

  • Johnstone S (2010) Stress and the epigenetic landscape: a link to the pathobiology of human diseases? Nature Rev Gen 11: 806–812

    Article  CAS  Google Scholar 

  • Jones A, Godfrey KM, Wood P, Osmond C, Goulden P, Phillips DI (2006) Fetal growth and the adrenocortical response to psychological stress. J Clin Endocrinol Metab 91: 1868–1871

    Article  CAS  PubMed  Google Scholar 

  • Kermack WO, McKendrick AG, McKinlay PL (1934) Death rates in Great Britain and Sweden; some general regularities and their significance. Lancet 31: 698–703

    Article  Google Scholar 

  • Kermack WO, McKendrick AG, McKinlay PL (2001) Death-rates in Great Britain and Sweden. Some general regularities and their significance. Int J Epidemiol 30: 678–683

    CAS  PubMed  Google Scholar 

  • Khan IY, Taylor P D, Dekou V, Seed PT, Lakasing L, Graham D, Dominiczak AF, Hanson MA, Poston L (2003) Gender-linked hypertension in offspring of lard-fed pregnant rats. Hypertension 41: 168–175

    Article  CAS  PubMed  Google Scholar 

  • Lampl M, Jeanty P (2003) Timing is everything: a reconsideration of fetal growth velocity patterns identifies the importance of individual and sex differences. Am J Hum Biol 15: 667–680

    Article  PubMed  Google Scholar 

  • Langley-Evans SC1, McMullen S (2010) Developmental origins of adult disease. Med Princ Pract 19: 87–98

    Article  PubMed  Google Scholar 

  • Lawlor DA, Lichtenstein P, Langstrom N (2011) Association of maternal diabetes mellitus in pregnancy with offspring adiposity into early adulthood: sibling study in a prospective cohort of 280,866 men from 248,293 families. Circulation 123: 258–265

    Article  PubMed  PubMed Central  Google Scholar 

  • McFall-Ngai MJ (2002) Unseen forces: the influence of bacteria on animal development. Dev Biol 242: 1–14

    Article  CAS  PubMed  Google Scholar 

  • Mueller BR, Bale TL (2008) Sex-specific programming of offspring emotionality after stress early in pregnancy. J Neurosci 28: 9055–9065

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • von Mutius E, Vercelli D (2010) Farm living: effects on childhood asthma and allergy. Nat Rev Immunol 10: 861–868

    Article  Google Scholar 

  • Nuyt AM, Alexander BT (2009) Developmental programming and hypertension. Curr Opin Nephrol Hypertens 18: 144–152

    Article  PubMed  PubMed Central  Google Scholar 

  • O’Regan D, Kenyon CJ, Seckl JR, Holmes MC (2004) Glucocorticoid exposure in late gestation in the rat permanently programs gender-specific differences in adult cardiovascular and metabolic physiology. Am J Physiol Endocrinol Metab 287: E863–E870

    Article  Google Scholar 

  • van Os J, Selten JP (1998) Prenatal exposure to maternal stress and subsequent schizophrenia: The May 1940 invasion of the Netherlands. Br J Psychiatry 172: 324–326

    Article  PubMed  Google Scholar 

  • Pincus M, Arck P (2012) Developmental programming of allergic diseases. Chem Immunol Allergy 98: 70–84

    Article  CAS  PubMed  Google Scholar 

  • Pincus M, Keil T, Rücke M, Bruenahl C, Magdorf K, Klapp BF, Douglas AJ, Paus R, Wahn U, Arck P (2010) Fetal origin of atopic dermatitis. J Allergy Clin Immunol 125: 273–275

    Article  PubMed  Google Scholar 

  • Plagemann A (2008) A matter of insulin: developmental programming of body weight regulation. J Matern Fetal Neonatal Med 21: 143–148

    Article  CAS  PubMed  Google Scholar 

  • Plagemann A (2011) Maternal diabetes and perinatal programming. Early Hum Dev 87: 743–747

    Article  CAS  PubMed  Google Scholar 

  • Prior LJ, Armitage JA (2009) Neonatal overfeeding leads to developmental programming of adult obesity: you are what you ate. J Physiol 587: 2419

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ravelli GP, Stein ZA, Susser MW (1976) Obesity in young men after famine exposure in utero and early infancy. N Engl J Med 295: 349–353

    Article  CAS  PubMed  Google Scholar 

  • Ray PF, Conaghan J, Winston RML, Handyside AH (1995) Increased number of cells and metabolic activity in male human preimplantation embryos following in vitro fertilization. J Reprod Fertil 104: 165–171

    Article  CAS  PubMed  Google Scholar 

  • Renz H, von Mutius E, Brandtzaeg P, Cookson WO, Autenrieth IB, Haller D (2011) Gene-environment interactions in chronic inflammatory disease. Nat Immunol 12: 273–277

    Article  CAS  PubMed  Google Scholar 

  • Reynolds RM (2010) Corticosteroid-mediated programming and the pathogenesis of obesity and diabetes. J Steroid Biochem Mol Biol 122: 3–9

    Article  CAS  PubMed  Google Scholar 

  • Schaub B, Liu J, Höppler S, Schleich I, Huehn J, Olek S, Wieczorek G, Illi S, von Mutius E (2009) Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells. J Allergy Clin Immunol 123: 774–782

    Article  CAS  PubMed  Google Scholar 

  • Seckl JR, Holmes MC (2007) Mechanisms of disease: glucocorticoids, their placental metabolism and fetal ‘programming’ of adult pathophysiology. Nat Clin Pract Endocrinol Metab 3: 479–488

    Article  CAS  PubMed  Google Scholar 

  • Shankar K, Harrell A, Liu X, Gilchrist JM, Ronis MJ, Badger TM (2008) Maternal obesity at conception programs obesity in the offspring. Am J Physiol Regul Integr Comp Physiol 294: R528–R538

    Article  Google Scholar 

  • Szyf M (2013) Lamarck revisited: epigenetic inheritance of ancestral odor fear conditioning. Nat Neurosci 17: 2–4

    Article  Google Scholar 

  • Thiele K, Kessler T, Arck P, Erhardt A, Tiegs G (2013) Acetaminophen and pregnancy: short- and long-term consequences for mother and child. J Reprod Immunol 97: 128–139

    Article  CAS  PubMed  Google Scholar 

  • Trivers RL, Willard DE (1973) Natural selection of parental ability to vary the sex ratio of offspring. Science 179: 90–92

    Article  CAS  PubMed  Google Scholar 

  • Xue Q, Zhang L (2009) Prenatal hypoxia causes a sex-dependent increase in heart susceptibility to ischemia and reperfusion injury in adult male offspring: role of protein kinase C epsilon. J Pharmacol Exp Ther 330: 624–632

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Arck, P.C., Hecher, K. (2017). Fetale Programmierung. In: Toth, B. (eds) Fehlgeburten Totgeburten Frühgeburten. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-50424-6_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-50424-6_2

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-50423-9

  • Online ISBN: 978-3-662-50424-6

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics