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Endokrinologie

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Fehlgeburten Totgeburten Frühgeburten

Zusammenfassung

Hormonelle Störungen stellen eine häufige Ursache für frühe Schwangerschaftsverluste dar. Endokrine Faktoren, die am Abortgeschehen beteiligt sind, sind u.a. Diabetes mellitus, polycystisches Ovar-Syndrom (PCOS), Schilddrüsenfunktionsstörungen, Hyperprolaktinämie und luteale Insuffizienz. Es werden verschiedene Behandlungsmöglichkeiten aufgezeigt und Praxistipps gegeben.

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Literatur

  • Andersen SL, Olsen J, Wu CS, Laurberg P (2014) Spontaneous abortion, stillbirth and hyperthyroidism: a danish population-based study. Eur Thyroid J 3: 164–167

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Angioni S, Sanna S, Magnini R, Melis GB, Fulghesu AM (2011) The quantitative insulin sensitivity check index is not able to detect early metabolic alterations in young patients with polycystic ovarian syndrome. Gynecol Endocrinol 27: 468–474

    Article  CAS  PubMed  Google Scholar 

  • Anselmo J, Cao D, Karrison T, Weiss RE, Refetoff S (2004) Fetal loss associated with excess thyroid hormone exposure. JAMA 292: 691–695

    Article  CAS  PubMed  Google Scholar 

  • Artini PG, Uccelli A, Papini F, Simi G, Di Berardino OM, Ruggiero M, Cela V (2013) Infertility and pregnancy loss in euthyroid women with thyroid autoimmunity. Gynecol Endocrinol 29: 36–41

    Article  CAS  PubMed  Google Scholar 

  • Bernardi LA, Cohen RN, Stephenson MD (2013) Impact of subclinical hypothyroidism in women with recurrent early pregnancy loss. Fertil Steril 100: 1326–1331

    Article  CAS  PubMed  Google Scholar 

  • Bonney RC, Franks S (1990) The endocrinology of implantation and early pregnancy. Baillieres Clin Endocrinol Metab 4: 207–231

    Article  CAS  PubMed  Google Scholar 

  • Bussen S, Steck T (1995) Thyroid autoantibodies in euthyroid non-pregnant women with recurrent spontaneous abortions. Hum Reprod 10: 2938–2940

    CAS  PubMed  Google Scholar 

  • Carp H (2015) A systematic review of dydrogesterone for the treatment of recurrent miscarriage. Gynecol Endocrinol 31: 422–430

    Article  CAS  PubMed  Google Scholar 

  • Christiansen OB (2006) Evidence-based investigations and treatments of recurrent pregnancy loss. Curr Opin Obstet Gynecol 18: 304–312

    Article  PubMed  Google Scholar 

  • Cocksedge KA, Saravelos SH, Metwally M, Li TC (2009) How common is polycystic ovary syndrome in recurrent miscarriage? Reprod Biomed Online 19: 572–576

    Article  CAS  PubMed  Google Scholar 

  • Coomarasamy A, Williams H, Truchanowicz E, Seed PT, Small R, Quenby S, Gupta P, Dawood F, Koot YE, Bender Atik R, Bloemenkamp KW, Brady R, Briley AL, Cavallaro R, Cheong YC, Chu JJ, Eapen A, Ewies A, Hoek A, Kaaijk EM, Koks CA, Li TC, MacLean M, Mol BW, Moore J, Ross JA, Sharpe L, Stewart J, Vaithilingam N, Farquharson RG, Kilby MD, Khalaf Y, Goddijn M, Regan L, Rai R (2015) A randomized trial of progesterone in women with recurrent miscarriages. N Engl J Med 373(22): 2141–2148

    Article  CAS  PubMed  Google Scholar 

  • Craig LB, Ke RW, Kutteh WH (2002) Increased prevalence of insulin resistance in women with a history of recurrent pregnancy loss. Fertil Steril 78: 487–490

    Article  PubMed  Google Scholar 

  • Glinoer D (1998) Thyroid hyperfunction during pregnancy. Thyroid 8: 859–864

    Article  CAS  PubMed  Google Scholar 

  • Glueck CJ, Phillips H, Cameron D, Sieve-Smith L, Wang P (2001) Continuing metformin throughout pregnancy in women with polycystic ovary syndrome appears to safely reduce first-trimester spontaneous abortion: a pilot study. Fertil Steril 75: 46–52

    Article  CAS  PubMed  Google Scholar 

  • Glueck CJ, Wang P, Goldenberg N, Sieve-Smith L (2002) Pregnancy outcomes among women with polycystic ovary syndrome treated with metformin. Hum Reprod 17: 2858–2864

    Article  CAS  PubMed  Google Scholar 

  • Glueck CJ, Goldenberg N, Pranikoff J, Khan Z, Padda J, Wang P (2013) Effects of metformin-diet intervention before and throughout pregnancy on obstetric and neonatal outcomes in patients with polycystic ovary syndrome. Curr Med Res Opin 29: 55–62

    Article  CAS  PubMed  Google Scholar 

  • Greene MF, Hare JW, Cloherty JP et al. (1989) First-trimester hemoglobin A1 and risk for major malformation and spontaneous abortion in diabetic pregnancy. Teratology 39: 225–231

    Article  CAS  PubMed  Google Scholar 

  • Haas DM, Ramsey PS (2013) Progestogen for preventing miscarriage. Cochrane Database Syst Rev 10: CD003511

    PubMed  Google Scholar 

  • Halasz M, Szekeres-Bartho J (2013) The role of progesterone in implantation and trophoblast invasion. J Reprod Immunol 97: 43–50

    Article  CAS  PubMed  Google Scholar 

  • Hirahara F, Andoh N, Sawai K, Hirabuki T, Uemura T, Minaguchi H (1998) Hyperprolactinemic recurrent miscarriage and results of randomized bromocriptine treatment trials. Fertil Steril 70: 246–252

    Article  CAS  PubMed  Google Scholar 

  • Jakubowicz DJ, Iuorno MJ, Jakubowicz S, Roberts KA, Nestler JE (2002) Effects of metformin on early pregnancy loss in the polycystic ovary syndrome. J Clin Endocrinol Metab 87: 524–529

    Article  CAS  PubMed  Google Scholar 

  • Kitzmiller JL, Wallerstein R, Correa A, Kwan S (2010) Preconception care for women with diabetes and prevention of major congenital malformations. Birth Defects Res A Clin Mol Teratol 88: 791–803

    Article  CAS  PubMed  Google Scholar 

  • Li TC, Spuijbroek MDEH, Tuckerman E, Anstie B, Loxley M, Laird SM (2000) Endocrinological and endometrial factors in recurrent miscarriage. Br J Obstet Gynaecol 107: 1975–1980

    Article  Google Scholar 

  • Matalon ST, Blank M, Ornoy A, Shoenfeld Y (2001) The association between anti-thyroid antibodies and pregnancy loss. Am J Reprod Immunol 45: 72–77

    Article  CAS  PubMed  Google Scholar 

  • Melamed N, Hod M (2009) Perinatal mortality in pregestational diabetes. Int J Gynaecol Obstet 104 (suppl 1): 20-24

    Article  Google Scholar 

  • Miller E, Hare JW, Cloherty JP et al. (1981) Elevated maternal hemoglobin A1c in early pregnancy and major congenital anomalies in infants of diabetic mothers. N Engl J Med 304: 1331–1334

    Article  CAS  PubMed  Google Scholar 

  • Mills JL, Simpson JL, Driscoll SG, Jovanovic-Peterson L, Van Allen M, Aarons JH, Metzger B, Bieber FR, Knopp RH, Holmes LB et al. (1988) Incidence of spontaneous abortion among normal women and insulin-dependent diabetic women whose pregnancies were identified within 21 days of conception. N Engl J Med 319: 1617–1623

    Article  CAS  PubMed  Google Scholar 

  • Misso ML, Costello MF, Garrubba M, Wong J, Hart R, Rombauts L, Melder AM, Norman RJ, Teede HJ (2013) Metformin versus clomiphene citrate for infertility in non-obese women with polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod Update 19: 2–11

    Article  CAS  PubMed  Google Scholar 

  • Morin-Papunen L, Rantala AS, Unkila-Kallio L, Tiitinen A, Hippeläinen M, Perheentupa A, Tinkanen H, Bloigu R, Puukka K, Ruokonen A, Tapanainen JS (2012) Metformin improves pregnancy and live-birth rates in women with polycystic ovary syndrome (PCOS): a multicenter, double-blind, placebo-controlled randomized trial. J Clin Endocrinol Metab 97:1492–1500

    Article  CAS  PubMed  Google Scholar 

  • Negro R, Stagnaro-Green A (2014) Diagnosis and management of subclinical hypothyroidism in pregnancy. BMJ 349: g4929

    Article  PubMed  Google Scholar 

  • Negro R, Formoso G, Mangieri T, Pezzarossa A, Dazzi D, Hassan H (2006) Levothyroxine treatment in euthyroid pregnant women with autoimmune thyroid disease: effects on obstetrical complications. J Clin Endocrinol Metab 91: 2587–2591

    Article  CAS  PubMed  Google Scholar 

  • Okon MA, Laird SM, Tuckerman EM, Li TC (1998) Serum androgen levels in women who have recurrent miscarriages and their correlation with markers of endometrial function. Fertil Steril 69: 682–690

    Article  CAS  PubMed  Google Scholar 

  • Palomba S, Orio F Jr, Falbo A, Russo T, Tolino A, Zullo F (2007) Clomiphene citrate versus metformin as first-line approach for the treatment of anovulation in infertile patients with polycystic ovary syndrome. J Clin Endocrinol Metab 92: 3498–3503

    Article  CAS  PubMed  Google Scholar 

  • Palomba S, Falbo A, Orio F Jr, Zullo F (2009) Effect of preconceptional metformin on abortion risk in epolycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. Fertil Steril 92: 1646–1658

    Article  CAS  PubMed  Google Scholar 

  • Pluchino N, Drakopoulos P, Wenger JM, Petignat P, Streuli I, Genazzani AR (2014) Hormonal causes of recurrent pregnancy loss (RPL). Hormones 13: 314–322

    Article  PubMed  Google Scholar 

  • Practice Committee of the American Society for Reproductive Medicine (2015) Current clinical irrelevance of luteal phase deficiency: a committee opinion. Fertil Steril 103: e27–32

    Google Scholar 

  • Praprotnik S, Agmon-Levin N, Porat-Katz BS, Blank M, Meroni PL, Cervera R, Miesbach W, Stojanovich L, Szyper-Kravitz M, Rozman B, Tomsic M, Shoenfeld Y (2010) Prolactin′s role in the pathogenesis of the antiphospholipid syndrome. Lupus 19: 1515–1519

    Article  CAS  PubMed  Google Scholar 

  • Rai R, Backos M, Rushworth F, Regan L (2000) Polycystic ovaries and recurrent miscarriage - a reappraisal. Hum Reprod 15: 612–615

    Article  CAS  PubMed  Google Scholar 

  • Sibai BM (2000) Risk factors, pregnancy complications, and prevention of hypertensive disorders in women with pregravid diabetes mellitus. J Matern Fetal Med 9: 62–65

    Article  CAS  PubMed  Google Scholar 

  • Smith ML, Schust DJ (2011) Endocrinology and recurrent early pregnancy loss. Semin Reprod Med 29: 482–490

    Article  PubMed  Google Scholar 

  • Stagnaro-Green A, Glinoer D (2004) Thyroid autoimmunity and the risk of miscarriage. Best Pract Res Clin Endocrinol Metab 18: 167–181

    Article  CAS  PubMed  Google Scholar 

  • Stagnaro-Green A, Roman SH, Cobin RH, el-Harazy E, Alvarez-Marfany M, Davies TF (1990) Detection of at-risk pregnancy by means of highly sensitive assays for thyroid autoantibodies. JAMA 264: 1422–1425

    Article  CAS  PubMed  Google Scholar 

  • Taylor PN, Minassian C, Rehman A, Iqbal A, Draman MS, Hamilton W, Dunlop D, Robinson A, Vaidya B, Lazarus JH, Thomas S, Dayan CM, Okosieme OE (2014) TSH levels and risk of miscarriage in women on long-term levothyroxine: a community-based study. J Clin Endocrinol Metab 99: 3895–3902

    Article  CAS  PubMed  Google Scholar 

  • Thatcher SS, Jackson EM (2006) Pregnancy outcome in infertile patients with polycystic ovary syndrome who were treated with metformin. Fertil Steril 85: 1002–1009

    Article  CAS  PubMed  Google Scholar 

  • The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group (2004) Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 81: 19–25

    Google Scholar 

  • Tulandi T, Al-Fozan HM (2015) Definition and etiology of recurrent pregnancy loss. Up to date, Version 20.0 Wolters Kluwer 2016

    Google Scholar 

  • Vissenberg R, van den Boogaard E, van Wely M, van der Post JA, Fliers E, Bisschop PH, Goddijn M (2012) Treatment of thyroid disorders before conception and in early pregnancy: a systematic review. Hum Reprod Update 18: 360–373

    Article  CAS  PubMed  Google Scholar 

  • Wang JX, Davies MJ, Norman RJ (2002) Obesity increases the risk of spontaneous abortion during infertility treatment. Obes Res 10: 551–554

    Article  PubMed  Google Scholar 

  • Ylinen K, Aula P, Stenman UH, Kesäniemi-Kuokkanen T, Teramo K (1984) Risk of minor and major fetal malformations in diabetics with high haemoglobin A1c values in early pregnancy. Br Med J 289: 345–346

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Gynäkologishe Endokrinologie und Fertilitätsstörungen, Im Neuenheimer Feld 440, 69120, Heidelberg, Deutschland

    Thomas Strowitzki

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  1. Thomas Strowitzki
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  1. Gynäkologische Endokrinologie und Reproduktionsmedizin, Medizinische Universität Innsbruck, Innsbruck, Austria

    Bettina Toth

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Strowitzki, T. (2017). Endokrinologie. In: Toth, B. (eds) Fehlgeburten Totgeburten Frühgeburten. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-50424-6_14

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  • DOI: https://doi.org/10.1007/978-3-662-50424-6_14

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  • Publisher Name: Springer, Berlin, Heidelberg

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  • Online ISBN: 978-3-662-50424-6

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