Skip to main content

Gesundheitsschädigende Wirkungen von Koffein

  • Chapter
  • First Online:
Koffein
  • 4181 Accesses

Zusammenfassung

Der Diskurs, ob Koffein gesundheitsfördernd oder gesundheitsschädlich sei, zieht sich schon über Jahrhunderte. Während in den letzten Jahren Meldungen über wissenschaftliche Studien, die positive Auswirkungen des Koffeinkonsums herausgefunden haben wollen, in den Medien stets präsent sind, tauchen jene, die über negative Auswirkungen berichten, kaum auf. Obwohl diese Studien selbstverständlich den gleichen wissenschaftlichen Interpretationsschwierigkeiten unterliegen, sollten sie genauso ernst genommen werden wie jene über die gesundheitsfördernde Wirkung. – Denn Koffein kann uns von der Zeugung bis ins Erwachsenenalter unter bestimmten Umständen auch schaden.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 24.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 34.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Literatur

  • Aepli A, Kurth S, Tesler N, Jennig, Huber R (2015) Caffeine consuming children and adolescents show altered sleep behavior and deep sleep. Brain Sci. 5:441–455

    Article  Google Scholar 

  • Alm B, Wennergren G, Norvenius G, Skjaerven R, Oyen N, Helweg-Larsen K, Lagercrantz H, Irgens LM (1999) Caffeine and alcohol as risk factors for sudden infant death syndrome. Nordic Epidemiological SIDS Study. Arch Dis Child 81(2):107–111

    Article  Google Scholar 

  • Alves MG, Martins AD, Silva BM, Oliveura PF (2015) Caffeine and male fertility: metabolic effects and oxidative profile in human Sertoli cells. Conference paper at encontro nacional pos-graduacao ciencias biologicas Universidade de Aveiro. DOI: 10.13140/RG.2.1.1323.6642

    Google Scholar 

  • Aref AA, Bussel II (2014) Dietary factors and the risk of glaucoma: a review. Therapeutic Advances Chronic Disease 5(4):188–194

    Article  Google Scholar 

  • Arria, MA, Caldeira KM, Kasperski SJ, Vincent KB, Griffiths RR, O´Grady KE (2011) Energy drink consumption and increased risk for alcohol dependence. Alcoholism 35(2):365–375

    Article  Google Scholar 

  • Aziz NAA, Ali ANA, Kamarudin MN, Shaari N, Hitam WHW, Yaakub A et al. (2015) Coffee intake and progression of glaucoma. Int J Clinical Nutrition 3(1):7–11

    Google Scholar 

  • Bailey DG, Malcolm J, Arnold O, Spence JD (1998) Grapefruit juice – drug interactions. Br J Clinical Pharmacology 46(2): 101–110

    Article  Google Scholar 

  • Bailey DN, Welbert RT, Naylor A (1982) A study of salicylate and caffeine excretion in the breast milk of two nursing mothers. J Anal Toxicol 6:64–86

    Article  Google Scholar 

  • Ballard TL, Halaweish FT, Stevermer CL, Agrawal P, Vukovich MD (2006) Naringin does not alter caffeine pharmacokinetics, energy expenditure, or cardiovascular haemodynamics in humans following caffeine consumption. Clin Exp Pharmacol Physiology 33(4):310–314

    Article  Google Scholar 

  • Banerjee P, Zabiullah A, Levien B, Fowler DR (2014) Fatal caffeine intoxication: A series of eight cases from 1999 to 2009. J Forensic Science. DOI: 10.1111/1556-4029.12387

    Google Scholar 

  • Beach CA, Bianchine JR, Gerber N (1984) The excretion of caffeine in the semen of men: Pharmacokinetics and comparison of the concentrations in blood and semen. J Clin Pharmacology 92:152–187

    Google Scholar 

  • Bekkhus M, Skjothaug T, Nordhagen R, Borge AIH (2010) Intrauterine exposure to caffeine and inattention/overactivity in children. Acta Paediatrica 99:925–928

    Article  Google Scholar 

  • Bennet JM, Rodrigues IM, Klein LC (2013) Effects of caffeine and stress on biomarkers of cardiovascular disease in healthy men and women with a family history of hypertension. Stress and Health 29:401–409

    Article  Google Scholar 

  • Berlin CM Jr, Denson HM, Daniel CH, Ward RM (1984) Disposition of dietary caffeine in milk, saliva, and plasma of lactating women. Pediatrics 73:59–63

    Google Scholar 

  • Bernstein GA, Carroll ME, Crosby RD, Perwien AR, Go FS, Benowitz NL (1994) Caffeine effects on learning, performance, and anxiety in normal school-age children. J American Acad Child & Adolescent Psychiatry 33:407–415

    Article  Google Scholar 

  • Bernstein GA, Carroll ME, Thuras PD, Cosgrove KP, Roth ME (1998) Caffeine withdrawal in school-age children. J American Acad Child & Adolescent Psychiatry 37:858–865

    Article  Google Scholar 

  • Bonaventura A, Rudant J, Goujon-Bellec St, Orsi L, Leverger G, Baruchel A et al. (2013) Childhood acute leukemia, maternal beverage intake during pregnancy, and metabolic polymorhisms. Cancer Causes Control 24:783–793

    Article  Google Scholar 

  • Bonsignore A1, Sblano S, Pozzi F, Ventura F, Dell’Erba A, Palmiere C (2014) A case of suicide by ingestion of caffeine. Forensic Sci Med Pathol.10(3):448–451

    Article  Google Scholar 

  • Bungum M (2012) Role of sperm DNA integrity in fertility, embryology – updates and highlights on classic topics. Pereira V (ed) InTech, http://www.intechopen.com/books/embryology-updates-and-highlights-on-classic-topics/role-of-sperm-dna-integrity-in-fertility (Zugriff: 06.06.2015)

    Google Scholar 

  • Calabrò RS, Italiano D, Gervasi G, Bramanti P (2012) Single tonic-clonic seizure after energy drink abuse. Epileps Behavior 23(3):384–385

    Article  Google Scholar 

  • Calamaro CJ, Yang K, Ratcliffe S, Chasens ER (2012) Wired at young age: the effect of caffeine and technology on sleep duration and body mass index in school-aged children. J Pediatric Health Care 26:276–282

    Article  Google Scholar 

  • Carrillo JA, Benitez J (2000) Clinically significant pharmacokinetic interactions between dietary caffeine and medications. Clinical Pharmacokinetics 39(2):127–153

    Article  Google Scholar 

  • Chandra P, Gaur A, Varma S (2011) Effect of caffeine on the intraocular pressure in patients with primary open angle glaucoma. Clin Ophthalmology 5:1623–1629

    Google Scholar 

  • Chavarro J, Karmon A, Sokol R (2014) IVF and alcohol and caffeine consumption in men. Presentation at the American Society for Reproductive Medicine. Annual meeting, Honolulu

    Google Scholar 

  • Chen L, Bell EM, Browne ML, Druschel CM, Romitti PA, Schmidt RJ et al. (2012) Maternal caffeine consumption and risk of congenital limb deficiencies. Birth Defects Research 95:1033–1034

    Article  Google Scholar 

  • Chen LW, Wu Y, Neelakantan N, Chong MF, Pan A, van Dam RM (2014) Maternal caffeine intake during pregnancy is associated with risk of low birth weight: a systematic review and dose-response meta-analysis. BMC Med 12:174. DOI:10.1186/s12916-014-0174-6

    Article  Google Scholar 

  • Chen LW, Wu Y, Neelakantan N, Chong MFF, Pan A, van Dam RM (2015) Maternal caffeine intake during pregnancy and risk of pregnancy loss: a categorical and dose-response meta-analysis of prospective studies. Public Health Nutrition. DOI: http://dx.doi.org/10.1017/S1368980015002463

    Google Scholar 

  • Chiu YH, Afeiche MC, Gaskins AJ, Williams PL, Mendiola J, Jorgensen N, Swan SH, Chavarro JE (2014) Sugar-sweetened beverage intake in relation to semen quality and reproductive hormone levels in young men. Human Reproduction 29(7):1575–1584

    Article  Google Scholar 

  • Choi JH, Ryan LM, Cramer DW, Hornstein MD, Missmer StA (2011) Effects of caffeine consumption by women and men on the outcome of in vitro fertilization. J Caffeine Research 1(1):29–34

    Article  Google Scholar 

  • Choi Y, Chang Y, Ryu S, Cho J, Rampal S, Zhang Y et al. (2015) Coffee consumption and coronary calcium in young and middle-aged asymptomatic adults. Heart. DOI:10.1136/heartjnl-2014-306663

    Google Scholar 

  • Chrościńska-Krawczyk M, Radzik I, Miziak B, Czuczwar SJ (2014) Safety considerations for patients with epilepsy taking antiepileptic drugs alongside caffeine or other methylxanthine derivatives. Expert Opin Drug Metab Toxicol. 10(7):981–989

    Article  Google Scholar 

  • Cirillo PM, Cohn BA, Krigbaum NY, Lee M, Brazil C, Factor-Livak P (2011) Effect of maternal coffee, smoking and drinking behavior on adult son´s semen quality: Prospective evidence from the Child Health and Development Studies. J Dev Orig Health Dis 2(6):375–386

    Article  Google Scholar 

  • Cole J (1833) On the delirious effects produced by drinking tea and coffee in excessive quantities. Lancet 2:274–278

    Article  Google Scholar 

  • Cooper C, Atkinson EJ, Wahner HW, O’Fallon WM, Riggs BL, Judd HL, Melton LJ III. (1992) Is caffeine consumption a risk factor for osteoporosis? J Bone Miner Res 7(4):465–471

    Article  Google Scholar 

  • Cornelis MC, El-Sohemy A, Kabagambe EK, Campos HC (2006) Coffee, CYP1A2 genotype and risk of myocardial infarction. JAMA 295(10):1135–1141

    Article  Google Scholar 

  • Davis NJ, Vaughan CP, Johnson TM, Goode PS, Burgio KL, Redden DT, Markland AD (2013) Caffeine intake and its association with urinary incontinence in United States men: results from National Health and Nutrition Examination Surveys 2005–2006 and 2007–2008. Journal Urology, 189(6):2170–2174

    Article  Google Scholar 

  • Deutsches Grünes Kreuz (2015) Kaffee und Gesundheit. http://dgk.de/das-dgk/arbeitsgemeinschaften-sektionen/kaffee-gesundheit.html (Zugriff: 22.11.2015)

    Google Scholar 

  • Dixon RE, Hwang, SJ, Britton FC, Sanders KM, Ward SM (2011) Inhibitory effect of caffeine on pacemaker activity in the oviduct is mediated by cAMP-regulated conductances. British Journal of Pharmacology 163:745–754

    Article  Google Scholar 

  • Dlugosz L, Bracken MB (1992) Reproductive effects of caffeine: A review. Epidemiological Review 14:83–98

    Google Scholar 

  • Dusseldorp M, Katan MB, van Vliet T, Demacker PM, Stalenhof AF(1991) Cholesterol-raising factor from boiled coffee does not pass a paper filter. Arteriosclerosis, Thrombosis, and Vascular Biology 11:586–593

    Article  Google Scholar 

  • EFSA (European Food Safety Authority) Scientific Opinion on the safety of caffeine. EFSA Journal 13(5):4102–1422 http://www.efsa.europa.eu/sites/default/files/scientific_output/files/main_documents/4102.pdf (Zugriff: 08.12.2015)

  • Eskenazi B (1993) Caffeine during pregnancy: Grounds for concern? JAMA 270(24):2973–2974

    Article  Google Scholar 

  • Ferraro PM, Taylor EN, Gambaro G, Curhan CC (2014) Caffeine intake and the risk of kidney stones. Am J Clinical Nutrition 100(6):1596–1603

    Article  Google Scholar 

  • Ford R, Schluter P, Mitchell E, Taylor B, Scragg R, Stewart A, The N, Osmond C (1998) Heavy caffeine intake in pregnancy and sudden infant death syndrome. Arch Dis Child 78(1):9–13

    Article  Google Scholar 

  • Fuchs P, Haefeli WE, Ledermann HR, Wenk M (1999) Xanthine oxidase inhibition by allopurinol affects the reliability of urinary caffeine metabolic ratios as markers for N-acetyltransferase 2 and CYP1A2 activities. Eur J Clin Pharmacol 54(11):869–876

    Article  Google Scholar 

  • Fuhr U, Wolff T, Harder S, Schymanski P, Staib AH (1990) Quinolone inhibition of cytochrome P-450-dependent caffeine metabolism in human liver microsomes. Drug Metabolism and Disposition 18(6):1005–1010

    Google Scholar 

  • Galéra C, Bernard JY, Van der Waerden J, Bouvard M-P, Lioret S, Forhan A et al. (2015) Prenatal caffeine exposure and child IQ at age 5.5 years: The EDEN Mother-Child Cohort. Biological Psychiatry: DOI:10.1016/j.biopsych.2015.08.034

    Google Scholar 

  • Giedd J (1999) Brain development, IX human brain growth. American J Psychiatry 156(1):4

    Article  Google Scholar 

  • Gleason JL, Richter HE, Redden DT, Goode PS, Burgio KL, Markland AD (2013) Caffeine and urinary incontinence in US women. International Urogynecology Journal, 24(2):295–302

    Article  Google Scholar 

  • Greenop KR1, Miller M, Attia J, Ashton LJ, Cohn R, Armstrong BK, Milne E (2014) Maternal consumption of coffee and tea during pregnancy and risk of childhood brain tumors: results from an Australian case-control study. Cancer Causes Control 25(10):1321–1327

    Article  Google Scholar 

  • Greenwood DC, Thatcher NJ, Ye L, Garrard L, Keogh G, King JG, Cade JE (2014) Caffeine intake during pregnancy and adverse birth outcomes: a systematic review and dose-response meta-analysis. Eur J Epidimiol 29:725–734

    Article  Google Scholar 

  • Guay DRP (2011) Quinolones In: Piscitelli SC, Rodvold KA, Pai MP (ed). Drug interactions in infectious diseases. Springer, New York

    Google Scholar 

  • Hahn KA, Wise LA, Rothman KJ, Mikkelsen EM, Brogly SB, Sorensen HAT et al. (2015) Caffeine and caffeinated beverage and risk of spontanous abortion. Human Reproduction: DOI:10.1093/humrep/dev063

    Google Scholar 

  • Hallström H, Byberg L, Glynn A, Lemming EW, Wolk A, Michaelsson K (2013) Long-term coffee consumption in relation to fracture risk and bone mineral density in women. Am J Epidemiology 178(6):898–909

    Article  Google Scholar 

  • Hallström H, Melhus H, Glynn A, Lind L, Syvänen A-C, Michaelsson K (2010) Coffee consumption and CYP1A2 genotype in relation to bone mineral density of the proximal femur in elderly men and women: a cohort study. Nutrition Metabolism 7:12. DOI:10.1186/1734-7075-7-12

    Article  Google Scholar 

  • Harnack L, Stang J, Story M (1999) Soft drink consumption among US children and adolescents: Nutritional consequences. J of the American Dietary Assoc 99:436–441

    Article  Google Scholar 

  • Hering-Hanit R, Gadoth N (2003) Caffeine-induced headache in children and adolescents. Cephalea 23:332–335

    Article  Google Scholar 

  • Hoyt AT, Browne M, Richardson S, Romitti P, Druschel Ch (2014) Maternal caffeine consumption and small for gestational age births: Results from a population based case-control study. Maternal and Child Health J 18(6):1540–1551

    Article  Google Scholar 

  • Infante S, Baeza ML, Calvo M, DeBarrio M, Rubio M, Herrero T (2002) Anaphylaxis due to caffeine. Allergy 58:681–682

    Article  Google Scholar 

  • Jargiello-Baszak M, Walek M, Tylus B, Czuczwar SJ (2011) Caffeine and the anticonvulsant potency of antiepileptic drugs: experimental and clinical data. Pharmacological Reports 63(1):12–18

    Article  Google Scholar 

  • Jensen, TK, Swan, ShH, Skakkebaek NE, Rasmussen S, Jorgenson N (2010) Caffeine intake and semen quality in a population of 2,554 young danish men. American Journal Epidemiology 171(8):883–891

    Article  Google Scholar 

  • Joeres R, Richter E (1987) Mexiletine and caffeine elimination. New Engl J Medicine 317(2):117

    Google Scholar 

  • Kapetanovic A, Avdic D (2014) Influence of coffee consumption on bone mineral density in postmenopausal women with estrogen deficiency in menstrual history. J Health Sciences 4(2):105–109

    Article  Google Scholar 

  • Klonoff-Cohen H, Bleha J, Lam-Kruglick P (2002) A prospective study of the effects of female and male caffeine consumption on the reproductive endpoints of IVF and gamete intra-Fallopian transfer. Human Reproduction 17(7):1746–1754

    Article  Google Scholar 

  • Kristjansson AF, Mann MJ, Sigfusdottir ID, James JE (2015) Mode of daily caffeine consumption among adolescents and the practice of mixing alcohol with energy drinks: Relationships to drunkenness. Journal Studies on Alcohol and Drugs 76(3):397–405

    Article  Google Scholar 

  • Larsson SC (2014) Coffee, tea, and cocoa and risk of stroke. Stroke 45:309–314

    Article  Google Scholar 

  • Larsson SC, Orsini N (2011) Coffee consumption and risk of stroke: A dose-response meta-analysis of prospective studies. Am J Epidemiol 174(9):993–1001

    Article  Google Scholar 

  • Leon de J (2004) Psychopharmacology: Atypical antipsychotic dosing: The effect of smoking and caffeine. Psychiatric Services 55(5): 491–493

    Article  Google Scholar 

  • Li D-K, Ferber JR, Odouli R (2015) Maternal caffeine intake during pregnancy and risk of obesity in offspring: A prospective cohort study. International Journal of Obesity 32:658–664

    Article  Google Scholar 

  • Li M, Wang M, Guo W, Wang J, Sun X (2011) The effect of caffeine on intraocular pressure: A systematic review and meta-analysis. Graefes Archive Exp Clin Ophtamology 249:435–442

    Article  Google Scholar 

  • Linnet KM, Wisborg K, Secher NJ, Thomsen PH, Obel C, Dalsgaard S, Henriksen TB (2009) Coffee consumption during pregnancy and the risk of hyperkinetic disorder and ADHD: A prospective cohort study. Acta Paediatr 98(1):173–179

    Article  Google Scholar 

  • Lorist MM, Snel J (2008) Caffeine, sleep and quality of life. In: Verster JC, Pandi Perumal SR, Streiner JD(ed.) Sleep and quality of life in clinical medicine. Springer, New York

    Google Scholar 

  • Macedo RM, Brenetagnis LG, De Lacerda SA (2015) Effects of coffee intake and intraperitoneal caffeine on bone repair process – A histologic and aistometric study. Brazilian Dental J 26(2):175–180

    Article  Google Scholar 

  • Marczinski CA, Stamates AL, Ossege J, Maloney SF, Bardgett ME, Brown CJ (2014) Subjective state, blood pressure and behavioral control changes procuced by an „energy shot“. J Caffeine Research 4(2):57–63

    Article  Google Scholar 

  • Martin CA, Cook C, Woodring JH, Burkhardt G, Guenthner G, Omar HA, Kelly TH (2008) Caffeine use: Association with nicotine use, aggression, and other psychopathology in psychiatric an pediatric outpatient adolescents. Scientific World Journal 22:512–516

    Article  Google Scholar 

  • Martin I, Lopez-Vilchez MA, Mur A et al. (2007) Neonatal withdrawal syndrome after chronic maternal drinking of mate. Ther Drug Monitor 29:127–129

    Article  Google Scholar 

  • Maslova E, Bhattacharya S, Lin S-W, Michels KB (2010) Caffeine consumption during pregnancy and risk of preterm birth: a meta-analysis. Am J Clin Nutr. DOI:10.3945/ajcn.2010.29789

    Google Scholar 

  • Mays DC, Camisa C, Cheney P, Pacula CM, Nawoot S, Gerber N (1987) Methoxsalen is a potent inhibitor of the metabolism of caffeine in humans. Clinical Pharmacology Therapeutics 42(6):621–626

    Article  Google Scholar 

  • Melchert H-U, Knopf H, Braemer-Hauth M, Gerding B, Pabel E. Association of serum caffeine concentrations with blood lipids in caffeine-drug users and nonusers – Results of German National Health Surveys from 1984–1999. Europ J Epidemiology 20(4):311–316

    Google Scholar 

  • Mester R, Toren P, Mizrachi I, Wolmer L, Karni N, Weizman A (1995) Caffeine withdrawal increases lithium blood levels. Biological Psychiatry 37(5):348–350

    Article  Google Scholar 

  • Mindell JA, Meltzer LJ, Carskadon MA, Chervin RD (2009) Developmental aspects of sleep hygiene: Findings from the 2004 National Sleep Foundation Sleep in America Poll. Sleep Med 10(7):771–779

    Article  Google Scholar 

  • Mioranza S, Nunes F, Marques DM, Fioreze GT, Rocha AS, Botton PHS et al. (2014) Prenatal caffeine intake differently affects synaptic proteins during fetal brain development. Int J Developmental Neuroscience 36:45–52

    Article  Google Scholar 

  • Mos L, Vriz O, Martina S (2015) Long-term cardiovascular and metabolic effects of coffee consumption in young hypertensive subjects: Results from the HARVEST study. Europ. Soc Cardiology 2015 Congress, Abstract 899 http://www.medscape.com/viewarticle/850629 (Zugriff: 10.11.2015)

  • Moussa MM (1983) Caffeine and sperm motility. Fertility and Sterility 39(6):845–848

    Article  Google Scholar 

  • Mueller NT, Jacobs Jr. DR, MacLehose RF, Demerath EW, Kelly SP, Dreyfus JG, Pereira MA (2015) Consumption of caffeinated and artificially sweetened soft drinks is associated with risk of early menarche. American J Clinical Nutrition. DOI:10.3945/ajcn.114.100958

    Google Scholar 

  • Munoz LM, Lonnerdal B, Keen CL, Dewey KG (1988) Coffee consumption as a factor in iron deficiency anemia among pregnant women and their infants in Costa Rica. Am J Clin Nutr 48:645–651

    Google Scholar 

  • Noguchi K, Matsuzaki T, Sakanashi M, Hamadate N, Uchida T, Kina-Tanada M et el. (2015) Effect of caffeine contained in a cup of coffee on microvascular function in healthy subjects. J Pharm Sc 127:217–222

    Article  Google Scholar 

  • O’Brien MC, McCoy TP, Rhodes SD, Wagoner A, Wolfson M (2008) Caffeinated cocktails: energy drink consumption, high-risk drinking, and alcohol-related consequences among college students. Acad Emerg Med 15(5):453–460

    Article  Google Scholar 

  • O´Keefe JH, Bhatti SK, Patil HR, DiNicolanonio JJ, Lucan SC, Lavie CJ (2013) Effects of habitual consumption on cardiometabolic disease, cardiovascular health, and all-cause mortality. J Am Coll Cardiol 62(12):1043–1051

    Article  Google Scholar 

  • Okubo H, Miyake Y, Tanaka K, Sasaki S, Hirota Y (2015) Maternal total caffeine intake, mainly from Japanese and Chinese tea, during pregnancy was associated with risk of preterm birth: the Osaka Maternal and Child Health Study. Nutrition research. DOI: http://dx.doi.org/10.1016/j.nutres.2015.02.009

    Google Scholar 

  • Olini N, Kurth S, Huber R (2013) The effects of caffeine on sleep and maturational markers in the rat. PLOS One. DOI:10.1371/journal.pone.0072539

    Google Scholar 

  • Olsen J (1991) Cigarette smoking, tea and coffee drinking, and subfecundity. American Journal of Epidemiology 133(7):734–739

    Google Scholar 

  • O’Neill CE, Levis SE, Schreiner DC, Amat J, Maier StF, Bachtel RK (2014) Effects of adolescent caffeine consumption on cocaine sensitivity. Neuropsychopharmacology. DOI:10.1038/npp.2014.278

    Google Scholar 

  • Oo CY, Burgio DE, Kuhn RC Desai N, McNamara PJl (1995) Pharmacokinetics of caffeine and its demethylated metabolites in lactation: Predictions of milk to serum concentration ratios. Pharm Res 12:313–316

    Article  Google Scholar 

  • Orbeta RL, Overpeck MD, Ramcharran D, Kogam MD, Ledsky R (2006) High caffeine intake in adolescents: Associations with difficulty sleeping an feeling tired in the morning. J of Adolescent Health 38:451–453

    Article  Google Scholar 

  • Owens JA, Mindell J, Baylor A (2014) Effect of energy drinks and caffeinated beverage consumption on sleep, mood, and performance in children and adolescents. Nutrition reviews. DOI:10.1111/nure.12150

    Google Scholar 

  • Pallanti S, Bernardi S, Quercioli L (2006) The shorter PROMIS Questionnaire and the internet addiction scale in the assessment of multiple addictions in a high-school population: Prevalence and related disability. CNS Spectrum 11:966–974

    Article  Google Scholar 

  • Pasquale LR, Wiggs JL, Willett WC, Kang JH (2012) The relationship between caffeine and coffee consumption and exfoliation glaucoma or glaucoma suspect: A prospective study in two cohorts. Investigative Ophthalmology Visual Science 53(10):6427–6433

    Article  Google Scholar 

  • Pauli S, James R (1746) A treatise on tobacco, tea, coffee, and chocolate: in which the advantages and disadvantages attending the use of these commodities, are not only impartially considered. Thomson Gale, Farmington Hill

    Google Scholar 

  • Plichart M, Menegaux F, Lacour B, Hartmann O, Frappaz D, Doz F et al. (2008) Parental smoking, maternal alcohol, coffee and tea consumption during pregnancy and childhood malignant central nervous system tumours: the ESCALE study (SFCE). Eur J Cancer Prev 17(4):376–383

    Article  Google Scholar 

  • Pohler H (2010) Caffeine intoxication and addiction. J nurse Practitioners 6(1):49–52

    Article  Google Scholar 

  • Pollak CP, Bright D (2003) Caffeine consumption and weekly sleep patterns in US seventh-, eight-, and ninth-grader. Pediatrics 111:42–46

    Article  Google Scholar 

  • Pomm D, Svikis D, Dillon P, Dick D, Kendler K (2015) Caffeine withdrawal in college students: Differences by gender and beverage type. Drug Alcohol Dependence e34–e117. DOI: http://dx.doi.org/101016/j.drugalcdep.2014.09.565

  • Price StR, Hilchey CA, Darredeau C, Fulton HG, Barrett SP (2010) Energy drink co-administration is associated with increased reported alcohol ingestion. Drug and Alcohol Review 29:331–333

    Article  Google Scholar 

  • Raaska K, Raitasuo V, Laitilia J, Neuvonen PJ (2004) Effect of caffeine-containing versus decaffeinated coffee on serum clozapine concentrations in hospitalised patients. Basic Clinical Pharmacology Toxicology 94:13–18

    Article  Google Scholar 

  • Rapaport JL, Elkins R, Neims A, Zahn T, Berg CJ (1984) Behavioral and autonomic effects of caffeine in normal boys. Dev Of Pharmacological Therapy 3:74–82

    Google Scholar 

  • Reissig CJ, Strain, EC, Griffiths RR (2009) Caffeinated energy drinks – A growing problem. Drug Alcohol Dependence 99(1–3):1–10

    Article  Google Scholar 

  • Rhee J, Kim R, Kim Y, Tam M, Lai Y, Keum N et al. (2015) Maternal caffeine consumption during pregnancy and risk of low birth weight: A dose-response meta-analysis of observational studies. PLoS ONE 10(7):e0132334. DOI:10.1371/journal.pone.0132334

    Google Scholar 

  • Richards G, Smith A (2015) Caffeine consumption and self-assessed stress, anxiety, and depression in secondary school children. J Psychopharmacology. DOI:10.117/0269881115612404

    Google Scholar 

  • Riemann D, Nissen C (2011) Substanzinduzierte Schlafstörungen und Schlafmittelmissbrauch. Bundesgesundheitsblatt 54:1325–1331

    Article  Google Scholar 

  • Riou LM, Ruiz M, Rieger JM, Macdonald TL, Watson DD, Linden J et al. (2002) Influence of propranolol, enalaprilat, verapamil, and caffeine on adenosine A2A-receptor–mediated coronary vasodilatation. J American College of Cardiology 40(9):1687–1694

    Article  Google Scholar 

  • Rivera-Calimlim L (1977) Drugs in breast milk. Drug Therapy 7:59–66

    Google Scholar 

  • Robillard R, Bouchard M, Cartier A, Nicolau L, Carrier J (2015) Sleep is more sensitive to high doses of caffeine in the middle years of life. J Psychopharmacol. 29(6):688–697

    Article  Google Scholar 

  • Ruxton CHS (2013) The suitability of caffeinated drinks for children: a systematic review of randomised controlled trials, observational studies and expert panel guidelines. J of Hum Nutrition & Dietetics. DOI:10.1111/jhn.12172

    Google Scholar 

  • Saadat SH, Ahmadi K, Panahi Y (2015) The effect of on-demand caffeine consumption on treating patients with premature ejaculation: a double-blind randomized clinical trial. Current Pharmaceutical Biotechnology 16(3):281–287

    Article  Google Scholar 

  • Samsonsen C, Bratehn G, Reimers A, Helde G, Brodtkorb E (2013) Is dietary caffeine involved in seizure precipitation? Epileps Behavior 28(2):147–150

    Article  Google Scholar 

  • Santos IS, Matijasevich A, Domingues MR (2012) Maternal caffeine consumption and infant nighttime waking: prospective cohort study. Pediatrics 129:860–868

    Article  Google Scholar 

  • Savoca MR, Evans CD, Wilson ME, Harshfield GA, Ludwig DA (2004) The Association of caffeinated beverages with blood pressure in adolescents. Arch Pediatr Adolesc Med 158: 473–477

    Article  Google Scholar 

  • Schmid TE, Eskenazi B, Baumgartner A, Marchetti F, Young S, Weldon R, Anderson D, Wyrobek AJ (2007) The effects of male age on sperm DNA damage in healthy non-smokers. Human Reproduction 22(1):180–187

    Article  Google Scholar 

  • Schmidt RJ, Romitti PA, Burns TL, Browne ML, Druschel CM, Olney RS (2009) National birth defects prevention study: maternal caffeine consumption and risk of neural tube defects. Research Clin Mol Neonatatology 85:879–889

    Google Scholar 

  • Seifert SM, Schaechter JL, Hershorin ER, Lipshultz StE (2011) Health effects of energy drinks on children, adolescents, and young adults. Pediatrics 127(3):511–528

    Article  Google Scholar 

  • Senspiel V, Elind E, Bacelis J, Staffan N, Gove J, Myhre R et al. (2013) Maternal caffeine intake during pregnancy is associated with birthweight but not with gestational length: results from a large prospective observational cohort study. BMC Medicine 11:42 http://www.biomedcentral.com/1741-7015/11/42 (Zugriff: 06.06.2015)

    Article  Google Scholar 

  • Shapiro RE (2007) Caffeine and headaches. Neurological Science 28:179–183

    Article  Google Scholar 

  • Shen J, Qu X, Zhang X (2014) Coffee, tea, and the risk of hip fracture: a meta-analysis. Osteoporosis International 25(1):141–150

    Article  Google Scholar 

  • Shirley KL, Hon YY, Penzak SR, Lam YWF, Spratlin V and Jann MW (2003) Correlation of cytochrome P450 (CYP) 1A2 activity using caffeine phenotyping and olanzapine disposition in healthy volunteers. Neuropsychopharmacology 28:961–966

    Google Scholar 

  • Spigset O (1998) Are adverse drug reactions from fluvoxamine caused by concomitant intake of caffeine? European J Clinical Pharmacology 54(8):665–666

    Article  Google Scholar 

  • Sowell ER, Thompson PM, Holmes CJ, Jernigan TL, Toga AW (1999) In vivo evidence for post-adolescent brain maturation in frontal and striatal regions. Nature Neuroscience 2:859–861

    Article  Google Scholar 

  • Stavchansky S, Combs A, Sagraves R et al. (1988) Pharmacokinetics of caffeine in breast milk and plasma after single oral administration of caffeine to lactating mothers. Biopharm Drug Dispos 9:285–299

    Article  Google Scholar 

  • Sun T, Guo J, Chen H, Zhang J, Zhang X, Jiang X, Wang F, Xu Z, Huang X, Sha J, Chan HC (2014) Maternal caffeine exposure impairs insulin secretion by pancreatic β-cells and increases the risk of type II diabetes mellitus in offspring. Cell Biol Int 38(10):1183–1193

    Article  Google Scholar 

  • Svartberg J, Midtby M, Bönaa KH, Sundsfjord J, Joakimsen RM, Jorde R (2003) The associations of age, lifestyle factors and chronic disease with testosterone in men: the Tromsö Study. Europ J of Endocrinology 149:145–152

    Article  Google Scholar 

  • Temple JL (2009) Caffeine use in children: What we know, what we have left to learn, and why we should worry. Neuroscience Biobehavioral Res 33(6):793–806

    Article  Google Scholar 

  • Thomas DB (1988) Neonatal abstinence syndrom. Medical Journal of Australia 148:598

    Google Scholar 

  • Thompolos ThP, Ntouvelis E, Diamantaras AA, Tzanoudaki M, Baka M, Hatzipantelis E et al. (2015) Maternal and childhood consumption of coffee, tea and cola beverages in association with childhood leukemia: a meta analysis. Cancer Epidemiology. DOI: http://dx.doi.org/10.1016/j.canep.2015.08.009

    Google Scholar 

  • Tuomilehto J, Tuomilehto-Wolf E, Virtala E, LaPorte R (1990) Coffee consumption as trigger for insulin dependent diabetes mellitus in childhood. British Medical Journal 300(6725):642–643

    Article  Google Scholar 

  • Ulbricht C, Conquer J, D’Auria D, Isaac R, Lynch M, Rusie et al. (2012) Caffeine clinical bottom line: An evidence-based systematic review by the National Standard Research Collaboration. Alternative Complementary Therapies18(6):324–328

    Article  Google Scholar 

  • Vasanti SM, Schulze MB, Hu FB (2006) Intake of sugar-sweetened beverages and weight gain: A systematic review. Am J Clinical Nutrition 84(2):274–288

    Google Scholar 

  • Vida K, Rácz J (2015) Prevalence and consequences of the consumption of alcohol mixed with energy drinks: A literature review. J Caffeine Research 5(1):11–29

    Article  Google Scholar 

  • Wahlländer A, Paumgartner G (1989) Effect of ketoconazole and terbinafine on the pharmacokinetics of caffeine in healthy volunteers. European J Clinical Pharmacology 37(3):279–283

    Article  Google Scholar 

  • Waizenegger J, Castriglia S, Winkler G, Schneider R, Ruge W, Kersting M, Alexy U, Lachenmeier DW (2011) Caffeine exposure in children and adolescents consuming ready-to-drink coffee products. J of Caffeine Res 1(4):200–205

    Article  Google Scholar 

  • Warzak WJ, Evans S, Floress MT, Gross AC, Stoolman S (2011) Caffeine consumption in young children. Journal Pediatrics 158:508–509

    Article  Google Scholar 

  • Winkelmayer WC, Stampfer MJ, Willett WC, Curhan GC (2005) Habitual caffeine intake and the risk of hypertension in women. JAMA 294(18):2330–2335

    Article  Google Scholar 

  • Ying HJ, Townsend MK, Curhan GC, Resnick NM, Grodstein F (2011) Caffeine intake and risk of stress, urgency, and mixed urinary incontinence. Journal Urology 185(5):1775–1780

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Beiglböck, W. (2016). Gesundheitsschädigende Wirkungen von Koffein. In: Koffein. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-49564-3_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-49564-3_4

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-49563-6

  • Online ISBN: 978-3-662-49564-3

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics