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The Utility of Genomics for Studying Primate Biology

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Genome Mapping and Genomics in Human and Non-Human Primates

Part of the book series: Genome Mapping and Genomics in Animals ((MAPPANIMAL,volume 5))

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Abstract

An overall theme of this volume is the utility of genomic approaches for the examination of primate (both human and nonhuman) biology. This volume also emphasizes biological characteristics that are relevant for risk of disease. Utilizing an evolutionary framework, the genomic study of nonhuman primates is shown to inform our knowledge of human biology. In this chapter, we supply a brief integrative synopsis of those chapters that most directly focus on nonhuman primate genomics and speculate upon where the post-genomic era may lead us.

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References

  • Aitman TJ, Boone C, Churchill GA, Hengartner MO, Mackay TF, Stemple DL (2011) The future of model organisms in human disease research. Nat Rev Genet 12:575–582

    Article  CAS  PubMed  Google Scholar 

  • Blangero J, MacCluer JW, Kammerer CM, Mott GE, Dyer TD, McGill HC Jr (1990) Genetic analysis of apolipoprotein A-I in two dietary environments. Am J Hum Genet 47:414–428

    PubMed Central  CAS  PubMed  Google Scholar 

  • Bozek K, Wei Y, Yan Z, Liu X, Xiong J, Sugimoto M, Tomita M, Pääbo S, Pieszek R, Sherwood CC, Hof PR, Ely JJ, Steinhauser D, Willmitzer L, Bangsbo J, Hansson O, Call J, Giavalisco P, Khaitovich P (2014) Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness. PLoS Biol 12(5):e1001871

    Google Scholar 

  • Chimpanzee Sequencing and Analysis Consortium (2005) Initial sequence of the chimpanzee genome and comparison with the human genome. Nature 437:69–87

    Article  Google Scholar 

  • Jaquish CE, Leland MM, Dyer T, Towne B, Blangero J (1997) Ontogenetic changes in genetic regulation of fetal morphometrics in baboons (Papio hamadryas subspp.). Hum Biol 69:831–848

    CAS  PubMed  Google Scholar 

  • Jasinska AJ, Lin MK, Service S, Choi OW, DeYoung J, Grujic O, Kong SY, Jung Y, Jorgensen MJ, Fairbanks LA, Turner T, Cantor RM, Wasserscheid J, Dewar K, Warren W, Wilson RK, Weinstock G, Jentsch JD, Freimer NB (2012) A non-human primate system for large-scale genetic studies of complex traits. Hum Mol Genet 21:3307–3316

    Google Scholar 

  • Liu X, Somel M, Tang L, Yan Z, Jiang X, Guo S, Yuan Y, He L, Oleksiak A, Zhang Y, Li N, Hu Y, Chen W, Qiu Z, Pääbo S, Khaitovich P (2012) Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques. Genome Res 22:611–622

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Mahaney MC, Williams-Blangero S, Blangero J, Leland MM (1993) Quantitative genetics of relative organ weight variation in captive baboons. Hum Biol 65:991–1003

    CAS  PubMed  Google Scholar 

  • Martin LJ, Mahaney MC, Bronikowski AM, Carey KD, Dyke B, Comuzzie AG (2002) Lifespan in captive baboons is heritable. Mech Ageing Dev 123:1461–1467

    Article  PubMed  Google Scholar 

  • Oler JA, Fox AS, Shelton SE, Rogers J, Dyer TD, Davidson RJ, Shelledy W, Oakes TR, Blangero J, Kalin NH (2010) Amygdalar and hippocampal substrates of anxious temperament differ in their heritability. Nature 466:864–868

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Rhesus Macaque Sequencing and Analysis Consortium (2007) The rhesus macaque genome. Science 316:235–237

    Article  Google Scholar 

  • Rogers J, Kochunov P, Lancaster J, Shelledy W, Glahn D, Blangero J, Fox P (2007) Heritability of brain volume, surface area and shape: an MRI study in an extended pedigree of baboons. Hum Brain Mapp 28:576–583

    Article  PubMed  Google Scholar 

  • Rogers J, Martin LJ, Comuzzie AG, Mann JJ, Manuck SB, Leland M, Kaplan JR (2004) Genetics of monoamine metabolites in baboons: overlapping sets of genes influence levels of 5-hydroxyindolacetic acid, 3-hydroxy-4-methoxyphenylglycol, and homovanillic acid. Biol Psychiatry 55:739–744

    Article  CAS  PubMed  Google Scholar 

  • Williams-Blangero S, Blangero J (1995) Heritability of age of first birth in captive olive baboons. Am J Primat 37:233–239

    Article  Google Scholar 

  • Williams-Blangero S, Blangero J, Murthy KK, Lanford RE (1996) Genetic analysis of serum alanine transaminase activity in normal and hepatitis C virus infected chimpanzees: an application of research-oriented genetic management. Lab Anim Sci 46:26–30

    Google Scholar 

  • Williams-Blangero S, Brasky K, Butler T, Dyke B (1993) Genetic analysis of hematological traits in chimpanzees (Pan troglodytes). Hum Biol 65:1013–1024

    CAS  PubMed  Google Scholar 

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Correspondence to Sarah Williams-Blangero .

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Williams-Blangero, S., Blangero, J. (2015). The Utility of Genomics for Studying Primate Biology. In: Duggirala, R., Almasy, L., Williams-Blangero, S., Paul, S., Kole, C. (eds) Genome Mapping and Genomics in Human and Non-Human Primates. Genome Mapping and Genomics in Animals, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-46306-2_1

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