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History of Neuroendocrine Tumors

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Neuroendocrine Tumours

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Abstract

Neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms that arise in many tissues throughout the body. They share common pathologic features but have a broad spectrum of clinical presentations and malignant behavior [1]. The history of NETs, their discovery and classification, the evolution of their treatment, and the scientists who were responsible for these advancements over the past two centuries are the background upon which we now base our modern understanding of these cancers. This chapter will highlight the contributions of scientists in the field of NETs and the gastrointestinal neuroendocrine system from which they derive.

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References

  1. Oberg K, Castellano D (2011) Current knowledge on diagnosis and staging of neuroendocrine tumors. Cancer Metastasis Rev 30:33–37

    Article  Google Scholar 

  2. Martin C (1927) Ernest Henry Starling: life and work. BMJ 1:900–904

    Article  Google Scholar 

  3. Pavlov I (1888) Die Innervation des Pankreas. Klin Wochenzeitung 32:667–675

    Google Scholar 

  4. Pavlov I (1897) Lektsii o rabote glavnykh pischchevaritel’nykh zhelez. Piroda, St. Petersburg

    Google Scholar 

  5. Pavlov I (1910) Lectures on the work of digestive glands. Charles Griffin and Company, London

    Google Scholar 

  6. Pavlov I (1940) Poln Sobr Trudov 1:410

    Google Scholar 

  7. Liu E, Oberg K (2010) The history and development of the gastroenteropancreatic endocrine axis. Endocrinol Metab Clin North Am 39(4):697–711

    Article  CAS  PubMed  Google Scholar 

  8. Modlin I (1990) From prout to the proton pump – a history of the science of gastric acid secretion and the surgery of peptic ulcer. Surg Gynecol Obstet 170:81–96

    CAS  PubMed  Google Scholar 

  9. Modlin I, Kidd M (2001) Ernest Starling and the discovery of secretin. J Clin Gastroenterol 32:187–192

    Article  CAS  PubMed  Google Scholar 

  10. Modlin IM, Shapiro MD, Kidd M (2004) Siegfried oberndorfer: origins and perspectives of carcinoid tumors. Hum Pathol 35(12):1440–1451

    Article  PubMed  Google Scholar 

  11. Bayliss W, Starling E (1902) The mechanism of pancreatic secretion. J Physiol 28:325–352

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  12. Babkin B (1951) Pavlov – a biography,Victor Gollancz, Ltd. London

    Google Scholar 

  13. Hirst B (2004) Secretin and the exposition of hormonal control. J Physiol 560:339

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  14. Gunga H-C (2005) Nathan Zuntz: his life and work in the fields of high altitude physiology and aviation medicine. Oxford University Press, Inc., New York

    Google Scholar 

  15. Henderson J (2005) Ernest Starling and ‘Hormones’: an historical commentary. J Endocrinol 184:5–10

    Article  CAS  PubMed  Google Scholar 

  16. Starling E (1905) The chemical correlation of the functions of the body. In: Meeting of the Royal College of Physicians. London

    Google Scholar 

  17. Moorison H (1869) Contributions to the microscopic anatomy of the pancreas, Jhons Hopkins Press, Baltimore. Berlin

    Google Scholar 

  18. Banting F, Best C (1922) The internal secretion of the pancreas. J Lab Clin Med 7:251–266

    CAS  Google Scholar 

  19. Sakura A (1988) Paul Langerhans (1847–1888): a centenary tribute. J R Soc Med 81:414–415

    Google Scholar 

  20. Heidenhain R (1870) Untersuchungen uber den Bau der Labdrusen. Arch Mikr Anat 6:368

    Article  Google Scholar 

  21. Drozdov I, Modlin I, Kidd M, Goloubinov V (2009) From Leningrad to London: the saga of Kulchitsky and the legacy of the enterochromaffin cell. Neuroendocrinology 89:1–12

    Article  PubMed  Google Scholar 

  22. Nikolas A (1891) Recherches sur l’epithelium de l-intestin grele. Intern Monatssch Anat Physiol 8:1

    Google Scholar 

  23. Kulchitsky N (1897) Zur Frage uber den Bau des Darmkanals. Arch Mikr Anat 49:7–35

    Google Scholar 

  24. Simard L, Campenhout T (1932) The embryonic development of argentaffin cells in the chick intestine. Anat Rec 53:141–159

    Google Scholar 

  25. Ciaccio M (1906) Sur une nouvelle espece cellulaire dans les glandes de Lieberkuhn. C R Seances Soc Biol Fil 60:76–77

    Google Scholar 

  26. Langhans T (1867) Uber einen Drusenpolyp im ileum. Virchows Arch Pathol Anat Physiol Klin Med 38:550–560

    Google Scholar 

  27. Lubarsch O (1888) Uber dem primaren Krebs des ileum nebst bemerkungen uber das gleichzeitige Vorkommen van Krebs und Tuberculose. Virchows Arch 111:280–317

    Article  Google Scholar 

  28. Ransom W (1890) A case of primary carcinoma of the ileum. Lancet 2:1020–1023

    Article  Google Scholar 

  29. Oberndorfer S (1907) Karzinoid Tumoren des Dunndarms. Frankf Z Pathol 1:426–432

    Google Scholar 

  30. Oberndorfer S (1928) Karzinoide Handbuch der Speziellen. In: Handbuch der Speziellen Pathologischen Anatomie und Histologie. Verlag von Julius Springer, Berlin, pp 814–847

    Google Scholar 

  31. Gosset A, Masson P (1914) Tumeurs endocrines se lappendice. Presse Med 25:237–240

    Google Scholar 

  32. Kull H (1925) Die chromaffinen Zellen des Verdauungstraktus. Z Mikr Anat Forsch 2:163

    Google Scholar 

  33. Feyter F (1938) Ueber diffuse endokrine epitheliale Organe. Zentralbl Innere Med 545:31–41

    Google Scholar 

  34. Rindi G, Leiter A, Kopin A, Bordi C, Solcia E (2004) The ‘normal’ endocrine cell of the gut: changing concepts and new evidence. Ann N Y Acad Sci 1014:1–12

    Article  CAS  PubMed  Google Scholar 

  35. Bartholin T (1668) Bartholinus anatomy in four books and four manuals. N Culpepper, London

    Google Scholar 

  36. Lindholm J (2000) Cushing’s syndrome: historical aspects. Pituitary 3:97–104

    Google Scholar 

  37. Coxe J (1827) On the function of the capsule renales. Am J Med Sci 6:40–49

    Article  Google Scholar 

  38. Schneider C (1655) Dissertatio de osse cribriformi. Wittenberg

    Google Scholar 

  39. Cunningham E (1879) A large sub-arachnoid cyst involving the greater part of the parietal lobe of the brain. J Anat Physiol 13:508–517

    PubMed Central  CAS  PubMed  Google Scholar 

  40. Fritsche C, Klebs E (1884) Ein Beitrag zur Pathologie des Riesenwuchses. Vogel, Leipzig

    Google Scholar 

  41. Landolt A, Zachmann M (1980) The Irish Giant: new observations concerning the nature of his ailment. Lancet 1:1311–1312

    Article  CAS  PubMed  Google Scholar 

  42. Schaefer E, Hering P (1908) The action of pituitary extracts upon the kidney. Philos Trans R Soc London Series B 199:1–29

    Article  Google Scholar 

  43. Bulloch W, Sequeira J (1905) On the relation of the suprarenal capsules to the sexual organs. Trans Path Soc London 56:189–208

    Google Scholar 

  44. Guthrie L, Emery W (1907) Precocious obesity, premature sexual and physical development, and hirsuties in relation to hypernephroma and other morbid conditions. Trans Clin Soc Lond 40:175–202

    Google Scholar 

  45. Cushing H (1912) The pituitary body and its disorders. Lippincott Comp, Philadelphia/London

    Google Scholar 

  46. Cushing H (1914) Surgical experiences with pituitary disorders. JAMA 63:1515–1525

    Article  Google Scholar 

  47. Carney J (1995) The search for Harvey Cushing’s patient, Minnie G., and the cause of her hypercortisolism. Am J Surg Pathol 19:100–108

    Article  CAS  PubMed  Google Scholar 

  48. Young WJ, Carney J, Musa B, Wulffstraat N, Lens J, Drexhage H (1989) Familial Cushing’s Syndrome due to primary pigmented nodular adrenocortical disease. Reinvestigation 50 years later. N Engl J Med 321:1659–1664

    Article  PubMed  Google Scholar 

  49. Reichman V (1919) Uber ein ungewohlisches Krankheitsbild bei Hypophysenadenom. Dtsch Arch Klin Med 130:133–150

    Google Scholar 

  50. Cushing H (1932) The basophilic adenomas of the pituitary body and their clinical manifestations (pituitary basophilism). Bull Johns Hopkins Hosp 50:137–195

    Google Scholar 

  51. Cushing H (1932) Further notes on pituitary basophilism. JAMA 99:281–284

    Article  Google Scholar 

  52. Cushing H (1933) Dyspituitarism: twenty years later; with special consideration of the pituitary adenomas. Arch Intern Med 51:487–557

    Article  CAS  Google Scholar 

  53. Thompson K, Cushing H (1932) Experimental pituitary basophilism. Proc Royal Soc Lond (Series B) 115:88–100

    Article  Google Scholar 

  54. Oppenheimer B, Fishberg A (1924) The association of hypertension with suprarenal tumors. Arch Intern Med 34:631–644

    Article  Google Scholar 

  55. Bishop P, Close H (1932) A case of basophil adenoma of the anterior lobe of the pituitary; “Cushing’s syndrome”. Guys Hosp Rep 82:143–153

    Google Scholar 

  56. Jores A (1935) Uber Hormonuntersuchungen bei Morbus Cushing. Klin Wochensch 14:1348–1352

    Article  Google Scholar 

  57. Collip J, Anderson E, Thomson D (1933) The adrenotropic hormone of the anterior pituitary lobe. Lancet 2:347–348

    Article  Google Scholar 

  58. Bauer J (1950) The so-called Cushing’s syndrome, its history, terminology, and differential diagnosis. Acta Med Scand 137:411–416

    Article  CAS  PubMed  Google Scholar 

  59. Belsky J, Cuello B, Svanson L, Simmons D, Jarrett R, Brasa F (1985) Cushing’s syndrome due to ectopic production of corticotropin-releasing factor. J Clin Endocrinol Metab 60:496–500

    Article  CAS  PubMed  Google Scholar 

  60. Carey R, Varma S, Drake C, Thorner M, Kovaces K, Rivier J, Vale W (1984) Ectopic secretion of corticotropin-releasing factor as a cause of Cushing’s syndrome. N Engl J Med 311:13–20

    Article  CAS  PubMed  Google Scholar 

  61. Christy N (1961) Adrenocorticotrophic activity in the plasma of patients with Cushing’s syndrome associated with pulmonary neoplasms. Lancet 1:85–86

    Article  CAS  PubMed  Google Scholar 

  62. Meador C, Liddle G, Island D (1962) Cause of Cushing’s syndrome in patients with tumors arising from “nonendocrine” tissue. J Clin Endocrinol Metab 22:693–703

    Article  CAS  PubMed  Google Scholar 

  63. Christy N (1971) Cushing’s syndrome: the natural disease. In: The human adrenal cortex. Harper & Row, New York, pp 360–364

    Google Scholar 

  64. The Discovery of Insulin (2009) In Nobelprize.org. Nobel Media AB 2014 Web.25 Feb 2015. http://www.nobelprize.org/educational/medicine/insulin/discovery-insulin.html

  65. Best C, Scott D (1923) The preparation of insulin. J Biol Chem 57:709–723

    CAS  Google Scholar 

  66. Simoni R, Hill R, Vaughan M (2002) The discovery of insulin: the work of Frederick Banting and Charles best. J Biol Chem 277:31–32

    Google Scholar 

  67. Harris S (1924) Hyperinsulinism and dysinsulinism. JAMA 83:729

    Article  Google Scholar 

  68. Liu S, Loucks H, Chou S, Chen K (1936) Adenoma of pancreatic islet cells with hypoglycemia and hyperinsulinism. J Clin Invest 15:249–260

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  69. Wilder R, Allan F, Power M, Robertson H (1927) Carcinoma of the islands of the pancreas. Hyperinsulinism and hypoglycemia. JAMA 89:348

    Article  CAS  Google Scholar 

  70. Howland G, Campbell W, Maltby E, Robinson W (1929) Dysinsulinism: convulsions and coma due to islet cell tumor of pancreas with operation and cure. JAMA 93:674

    Article  Google Scholar 

  71. Whipple A (1938) The surgical therapy of hyperinsulinism. J Int Chir 3:237–276

    Google Scholar 

  72. Whipple A, Frantz V (1935) Adenoma of islet cells with hyperinsulinism. A review. Ann Surg 101:1299

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  73. Sailer S (1946) Massive islet cell tumor of the pancreas without hypoglycemia. Surg Gynecol Obstet 82:301–305

    CAS  PubMed  Google Scholar 

  74. Yeung M, Pasieka J (2009) Gastrinomas: a historical perspective. J Surg Oncol 100:425–433

    Article  PubMed  Google Scholar 

  75. Zollinger R, Ellison E (1955) Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas. Ann Surg 142:709–723

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  76. Eiseman B, Maynard R (1956) A noninsulin producing islet cell adenoma associated with progressive peptic ulceration (the Zollinger-Ellison syndrome). Gastroenterology 31:296–304

    CAS  PubMed  Google Scholar 

  77. Ellison E, Wilson S (1967) The Zollinger-Ellison syndrome updated. Surg Clin North Am 47:1115–1124

    CAS  PubMed  Google Scholar 

  78. Komaroz S (1942) Methods of isolation of a specific gastric secretagogue from the pyloric mucous membrane and its chemical properties. Rev Can Biol 1:191–207

    Google Scholar 

  79. Gregory R, Grossman M, Tracy H (1967) Nature of the gastric secretagogue in Zollinger-Ellison tumours. Lancet 2:543–544

    Article  CAS  PubMed  Google Scholar 

  80. Zollinger R (1981) The Zollinger-Ellison syndrome. World J Surg 5:773–775

    Article  Google Scholar 

  81. McGuigan J, Trudeau W (1968) Immunochemical measurement of elevated levels of gastrin in the serum of patients with pancreatic tumors of the Zollinger-Ellison variety. N Engl J Med 278:1308–1313

    Article  CAS  PubMed  Google Scholar 

  82. Jaffe B, Paskin G, Kaplan E (1972) Diagnosis of occult Zollinger-Ellison tumors by gastrin radioimmunoassay. Cancer 29:694–700

    Article  CAS  PubMed  Google Scholar 

  83. Oberhelman H, Nelsen T (1964) Surgical consideration in the management of ulcerogenic tumors of the pancreas and duodenum. Am J Surg 108:132–141

    Article  PubMed  Google Scholar 

  84. Fiddian-Green R (1978) Cimetidine or surgery for the Zollinger-Ellison syndrome? Gastroenterology 75:163–164

    CAS  PubMed  Google Scholar 

  85. Thompson M, Vanables C, Miller I (1975) Letter: Metiamide in Zollinger-Ellison syndrome. Lancet 1:35–36

    Article  CAS  PubMed  Google Scholar 

  86. Richardson C, Walsh J (1976) The value of a histamine H2-receptor antagonist in the management of patients with the Zollinger-Ellison syndrome. N Engl J Med 294:133–135

    Article  CAS  PubMed  Google Scholar 

  87. Eads J, Meropol N (2012) A new era for the systemic therapy of neuroendocrine tumors. Oncologist 17:326–338

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  88. Kulke M, Sui L, Tepper J (2011) Future directions in the treatment of neuroendocrine tumors: consensus report of the National Cancer Institute Neuroendocrine Tumor clinical trials planning meeting. J Clin Oncol 29:934–943

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  89. Erdheim J (1903) Zur normalen und pathologischen Histologie der Glandula thyreoidea, parathyroidea und Hypophysis. Beit Z Path Anat Z Allg Path 33:158–236

    Google Scholar 

  90. Carney J (2005) Familial multiple endocrine neoplasia: the first 100 years. Am J Surg Pathol 29:254–274

    Article  PubMed  Google Scholar 

  91. Cushing H, Davidoff L (1927) The pathological findings in four autopsied cases of acromegaly with a discussion of their significance. Rockefeller Institute for Medical Research, New York, pp 1–77

    Google Scholar 

  92. Lloyd P (1929) A case of hypophyseal tumor with associated tumor-like enlargement of the parathyroids and islands of Langerhans. Bull Johns Hopkins Hospital 45:1–14

    Google Scholar 

  93. Underdahl L, Woolner L, Black B (1953) Multiple endocrine adenomas: report of 8 cases in which the parathyroids, pituitary and pancreatic islets were involved. J Clin Endocrinol Metab 13:20–47

    Article  CAS  PubMed  Google Scholar 

  94. Wermer P (1973) Syndrome d’hyperplasie adenomateuse polyendocrienne familiale. Actual Endocrinol 13:5–13

    CAS  Google Scholar 

  95. Sipple J (1961) The association of pheochromocytoma with carcinoma of the thyroid gland. Am J Med 31:163–166

    Article  Google Scholar 

  96. Kaye R, Zak F (1964) Co-existent pheochromocytoma and thyroid carcinoma (Sipple’s syndrome). J Mt Sinai Hosp 31:476–486

    CAS  Google Scholar 

  97. Gagel R, Jackson C, Ponder B et al (1989) Multiple endocrine neoplasia type 2 syndromes: nomenclature recommendations from the workshop organizing committee. Henry Ford Hosp Med J 37:99

    Google Scholar 

  98. Spence RW, Burns-Cox CJ (1975) ACTH-secreting ‘apudoma’ of gallbladder. Gut 16:473–476

    Article  PubMed Central  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Surgery, Surgical Oncology, Vanderbilt University Medical Center, Nashville, TN, USA

    Paula Marincola MD & Eric H. Liu MD

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  1. Paula Marincola MD
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  2. Eric H. Liu MD
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Correspondence to Paula Marincola MD .

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Editors and Affiliations

  1. Department of Medical Oncology, Hacettepe University Cancer Institute, Ankara, Turkey

    Suayib Yalcin

  2. Department of Endocrine Oncology, Uppsala University Hospital, Uppsala, Sweden

    Kjell Öberg

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Marincola, P., Liu, E.H. (2015). History of Neuroendocrine Tumors. In: Yalcin, S., Öberg, K. (eds) Neuroendocrine Tumours. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45215-8_2

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