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Liposomal Gels in Enhancing Skin Delivery of Drugs

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Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement

Abstract

Liposomes are used as carriers to deliver the entrapped drugs into the skin, beneath the skin or into the systemic circulation, but the major limitation of using liposomes topically onto the skin is the liquid nature of the preparation, as they may leak from the application site upon their administration. However, this disadvantage of using liposome dispersion can be overcome by their incorporation in an adequate vehicle, where original structure of vesicles is preserved and their rheological and/or mucoadhesive properties are adjusted. This can be achieved by adding gelling agents into liposomal dispersions or by incorporating liposome dispersions into hydrogels, when liposomal gels are formed.

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Abbreviations

Chol:

Cholesterol

DSPC-Chol:

Distearoyl-glycero-PC and cholesterol

EPC:

Egg phosphatidylcholine

EPC-Na:

Egg phosphatidylglycerol sodium

HEC:

Hydroxyethyl cellulose

HPC:

Hydrogenated PC

HPMC:

Hydroxypropyl methylcellulose

PC:

Phosphatidylcholine

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Authors and Affiliations

  1. Department of Pharmacy, Health and Nutrition Sciences, University of Calabria, Via P. Bucci, Arcavacata di Rende, Cosenza, 87036, Italy

    Lorena Tavano PhD

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  1. Lorena Tavano PhD
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Correspondence to Lorena Tavano PhD .

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Editors and Affiliations

  1. Apoteka "Beograd", Belgrade, Serbia

    Nina Dragicevic

  2. San Francisco, California, USA

    Howard I. Maibach

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Tavano, L. (2015). Liposomal Gels in Enhancing Skin Delivery of Drugs. In: Dragicevic, N., Maibach, H. (eds) Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45013-0_23

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  • DOI: https://doi.org/10.1007/978-3-662-45013-0_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-45012-3

  • Online ISBN: 978-3-662-45013-0

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