Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement

Drug Manipulation Strategies and Vehicle Effects

  • Nina Dragicevic
  • Howard I. Maibach

Table of contents

  1. Front Matter
    Pages i-xvi
  2. The Skin

    1. Front Matter
      Pages 1-1
    2. Annett Schroeter, Adina Eichner, Josefin Mueller, Reinhard H. H. Neubert
      Pages 19-38
    3. Laurène Roussel, Rawad Abdayem, Elodie Gilbert, Fabrice Pirot, Marek Haftek
      Pages 69-90
  3. Penetration Enhancement Techniques in Skin Delivery

    1. Front Matter
      Pages 91-91
    2. Jelena Predic Atkinson, Howard I. Maibach, Nina Dragicevic
      Pages 93-108
    3. Rina Kuswahyuning, Jeffrey E. Grice, Hamid R. Moghimi, Michael S. Roberts
      Pages 109-134
  4. Drug Manipulation Strategies in Penetration Enhancement

    1. Front Matter
      Pages 135-135
    2. Kenneth B. Sloan, Jennifer Synovec, Scott C. Wasdo
      Pages 137-150
    3. Vishwas Rai, Lakshmi Raghavan
      Pages 151-161
    4. Stuart A. Jones, Sarah Fiala, Marc B. Brown
      Pages 163-173
    5. Liang Fang, Honglei Xi, Dongmei Cun
      Pages 175-187
    6. Thorsteinn Loftsson
      Pages 189-205
  5. Influence of Vehicle Effects in Penetration Enhancement

    1. Front Matter
      Pages 207-207
  6. Emulsions as Vehicles for Skin Delivery

    1. Front Matter
      Pages 221-221
    2. Wesam R. Kadhum, Hiroaki Todo, Kenji Sugibayashi
      Pages 243-253
    3. Victoria Klang, Julia C. Schwarz, Claudia Valenta
      Pages 255-266
    4. Yves Chevalier, Marie-Alexandrine Bolzinger, Stéphanie Briançon
      Pages 267-281
  7. Gels as Vehicles for Skin Delivery

    1. Front Matter
      Pages 283-283
    2. Teresa Cerchiara, Federica Bigucci, Barbara Luppi
      Pages 285-297
    3. I. M. Shaikh, K. R. Jadhav, V. J. Kadam
      Pages 299-313
    4. Damien Salmon, Laurène Roussel, Elodie Gilbert, Plamen Kirilov, Fabrice Pirot
      Pages 315-328

About this book


This truly comprehensive reference, in a mini-series format with five volumes, offers a detailed description of both well-known and recently introduced methods for percutaneous penetration enhancement. The first three volumes are devoted to the broad range of chemical methods used to enhance the skin delivery of drugs, including the vast variety of chemical penetration enhancers, drug and vehicle manipulation strategies, nanocarriers, and many others. The fourth volume discusses the diverse physical methods used in penetration enhancement, such as sonophoresis, iontophoresis, electroporation, microporation, laser ablation, and microneedles. Determination of drug penetration is covered in the final volume, with a focus especially on mathematics in skin permeation and modern analytical techniques adapted to assess and measure penetration. This edition of Percutaneous Penetration Enhancers will be an invaluable resource for researchers, pharmaceutical scientists, practitioners, and also students.


Drug manipulation Microemulsion as nanovehicles Skin absorption Skin delivery Transdermal spray

Editors and affiliations

  • Nina Dragicevic
    • 1
  • Howard I. Maibach
    • 2
  1. 1.Apoteka "Beograd"BelgradeSerbia
  2. 2.San FranciscoUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2015
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine
  • Print ISBN 978-3-662-45012-3
  • Online ISBN 978-3-662-45013-0
  • Buy this book on publisher's site
Industry Sectors
Chemical Manufacturing
Health & Hospitals
Consumer Packaged Goods