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Hydrogel Vehicles for Hydrophilic Compounds

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Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement

Abstract

Hydrogels are three-dimensional insoluble networks able to imbibe large amount of water. They can be used in various fields including pharmaceutical and biomedical applications owing to their physical and chemical properties such as swelling behavior and chemical structure. Different methods used for the production of hydrogels as well as hydrogels based on several polymers such as chitosan, polyvinyl alcohol, and alginate have been reported. Moreover, the applications of hydrogels in transdermal drug delivery were described. In particular, the attention was focused on hydrogels as semisolid systems and film-based systems (matrix-type systems, membrane-coated systems, and film-forming solution) able to minimize skin irritation, promote adhesion properties, guarantee dosage flexibility, enhance patient acceptability, and improve ease of use.

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Authors and Affiliations

  1. Department of Pharmacy and Biotechnology-FaBiT, Bologna University, Via San Donato 19/2, Bologna, 40127, Italy

    Teresa Cerchiara, Federica Bigucci & Barbara Luppi

Authors
  1. Teresa Cerchiara
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  2. Federica Bigucci
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  3. Barbara Luppi
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Corresponding author

Correspondence to Teresa Cerchiara .

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Editors and Affiliations

  1. Apoteka "Beograd", Belgrade, Serbia

    Nina Dragicevic

  2. San Francisco, California, USA

    Howard I. Maibach

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Cerchiara, T., Bigucci, F., Luppi, B. (2015). Hydrogel Vehicles for Hydrophilic Compounds. In: Dragicevic, N., Maibach, H. (eds) Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45013-0_20

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  • DOI: https://doi.org/10.1007/978-3-662-45013-0_20

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