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Mechanisms of Uptake and Interaction of Platinum Based Drugs in Eukaryotic Cells

  • Lukas Nejdl
  • Jiri Kudr
  • Iva Blazkova
  • Dagmar Chudobova
  • Sylvie Skalickova
  • Branislav Ruttkay-Nedecky
  • Vojtech Adam
  • Rene KizekEmail author
Chapter
Part of the Environmental Science and Engineering book series (ESE)

Abstract

The platinum group elements are significant compounds used in numerous fields of human life. Besides of often discussed toxic effect the platinum compounds show the therapeutic effects. Nowadays, platinum-based cytostatic are still the most frequently used drugs in oncology. Due to their proved medicinal purposes the behavior in the organism should to be intensively studied as well as their interactions with DNA and other important biological molecules. This review summarizes the recent results in the platinum drug field and discusses the behavior of platinum compounds in cells. The interaction of platinum and DNA with respect to the change of the DNA structure are also clarified.

Keywords

Platinum Group Element Platinum Complex Platinum Compound Platinum Drug Ammine Ligand 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

The financial support from the projects NanoBioMetalNet CZ.1.07/2.4.00/31.0023 is highly acknowledged.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Lukas Nejdl
    • 1
  • Jiri Kudr
    • 1
  • Iva Blazkova
    • 1
  • Dagmar Chudobova
    • 1
  • Sylvie Skalickova
    • 1
  • Branislav Ruttkay-Nedecky
    • 1
    • 2
  • Vojtech Adam
    • 1
    • 2
  • Rene Kizek
    • 1
    • 2
    Email author
  1. 1.Department of Chemistry and BiochemistryMendel University in BrnoBrnoCzech Republic
  2. 2.Central European Institute of TechnologyBrno University of TechnologyBrnoCzech Republic

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