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Quantitative Traits and Quantitative Genetics

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Genetics of the Mouse

Abstract

In contrast with qualitative or dichotomous traits, quantitative traits are measured using quantitative or semi-quantitative variables and their inheritance is controlled by multiple genes acting independently or in association. Quantitative traits are also influenced to varying degrees by the environment and this explains why they are often designated complex traits, with the adjective “complex” referring more to the determinism of the phenotypic expression than to the trait itself.

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References

  • Brahic M, Bureau JF (1998) Genetics of susceptibility to Theiler’s virus infection. BioEssays 20:627–633

    Article  CAS  PubMed  Google Scholar 

  • Burgio G, Szatanik M, Guénet JL, Arnau MR, Panthier JJ, Montagutelli X (2007) Interspecific recombinant congenic strains between C57BL/6 and mice of the Mus spretus species: a powerful tool to dissect genetic control of complex traits. Genetics 177:2321–2333

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Burgio G, Baylac M, Heyer E, Montagutelli X (2012) Exploration of the genetic organization of morphological modularity on the mouse mandible using a set of interspecific recombinant congenic strains between C57BL/6 and mice of the Mus spretus species. G3 (Bethesda) 2:1257–1268. doi: 10.1534/g3.112.003285

  • Churchill GA, Airey DC, Allayee H, Angel JM, Attie AD, Beatty J, Beavis WD, Belknap JK, Bennett B, Berrettini W, Bleich A, Bogue M, Broman KW, Buck KJ, Buckler E, Burmeister M, Chesler EJ, Cheverud JM, Clapcote S, Cook MN, Cox RD, Crabbe JC, Crusio WE, Darvasi A, Deschepper CF, Doerge RW, Farber CR, Forejt J, Gaile D, Garlow SJ, Geiger H, Gershenfeld H, Gordon T, Gu J, Gu W, de Haan G, Hayes NL, Heller C, Himmelbauer H, Hitzemann R, Hunter K, Hsu HC, Iraqi FA, Ivandic B, Jacob HJ, Jansen RC, Jepsen KJ, Johnson DK, Johnson TE, Kempermann G, Kendziorski C, Kotb M, Kooy RF, Llamas B, Lammert F, Lassalle JM, Lowenstein PR, Lu L, Lusis A, Manly KF, Marcucio R, Matthews D, Medrano JF, Miller DR, Mittleman G, Mock BA, Mogil JS, Montagutelli X, Morahan G, Morris DG, Mott R, Nadeau JH, Nagase H, Nowakowski RS, O’Hara BF, Osadchuk AV, Page GP, Paigen B, Paigen K, Palmer AA, Pan HJ, Peltonen-Palotie L, Peirce J, Pomp D, Pravenec M, Prows DR, Qi Z, Reeves RH, Roder J, Rosen GD, Schadt EE, Schalkwyk LC, Seltzer Z, Shimomura K, Shou S, Sillanpää MJ, Siracusa LD, Snoeck HW, Spearow JL, Svenson K, Tarantino LM, Threadgill D, Toth LA, Valdar W, de Villena FP, Warden C, Whatley S, Williams RW, Wiltshire T, Yi N, Zhang D, Zhang M, Zou F; Complex Trait Consortium (2004) The collaborative cross, a community resource for the genetic analysis of complex traits. Nat Genet 36:1133–1137

    Google Scholar 

  • Churchill GA, Gatti DM, Munger SC, Svenson KL (2012) The diversity outbred mouse population. Mamm Genome 23:713–718

    Article  PubMed Central  PubMed  Google Scholar 

  • Cutler G, Kassner PD (2008) Copy number variation in the mouse genome: implications for the mouse as a model organism for human disease. Cytogenet Genome Res 23:297–306

    Article  Google Scholar 

  • Darvasi A (1998) Experimental strategies for the genetic dissection of complex traits in animal models. Nat Genet 18:19–24

    Article  CAS  PubMed  Google Scholar 

  • Grisel JE, Belknap JK, O’Toole LA, Helms ML, Wenger CD, Crabbe JC (1997) Quantitative trait loci affecting methamphetamine responses in BXD recombinant inbred mouse strains. J Neurosci 17:745–754

    Google Scholar 

  • Groot PC, Moen CJ, Dietrich W, Stoye JP, Lander ES, Demant P (1992) The recombinant congenic strains for analysis of multigenic traits: genetic composition. FASEB J 10:2826–2835

    Google Scholar 

  • Lander ES, Botstein D (1989) Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121:185–199

    CAS  PubMed Central  PubMed  Google Scholar 

  • Li R, Lyons MA, Wittenburg H, Paigen B, Churchill GA (2005) Combining data from multiple inbred line crosses improves the power and resolution of quantitative trait loci mapping. Genetics 169:1699–1709

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Mackay TFC (2009) Q&A: genetic analysis of quantitative traits. J Biol 8:23

    Article  PubMed Central  PubMed  Google Scholar 

  • Mackay TFC, Stone EA, Ayroles JF (2009) The genetics of quantitative traits: challenges and prospects. Nat Rev Genet 10:565–577

    Article  CAS  PubMed  Google Scholar 

  • Singer JB, Hill AE, Burrage LC, Olszens KR, Song J, Justice M, O’Brien WE, Conti DV, Witte JS, Lander ES, Nadeau JH (2004) Genetic dissection of complex traits with chromosome substitution strains of mice. Science 304:445–448

    Article  CAS  PubMed  Google Scholar 

  • Threadgill DW, Hunter KW, Williams RW (2002) Genetic dissection of complex and quantitative traits: from fantasy to reality via a community effort. Mamm Genome 13:175–178

    Article  CAS  PubMed  Google Scholar 

  • Threadgill DW, Churchill GA (2012) Ten years of the collaborative cross. G3 (Bethesda) 2:153–156

    Google Scholar 

  • Xiao J, Liang Y, Li K, Zhou Y, Cai W, Zhou Y, Zhao Y, Xing Z, Chen G, Jin L (2010) A novel strategy for genetic dissection of complex traits: the population of specific chromosome substitution strains from laboratory and wild mice. Mamm Genome 7–8:370–376

    Article  Google Scholar 

Publications of General Interest

  • Falconer DS, Mackay TFC (1996) Introduction to quantitative genetics, 4th edn. Longman, Harlow

    Google Scholar 

  • Flint J, Valdar W, Shifman S, Mott R (2005) Strategies for mapping and cloning quantitative traits in rodents. Nat Rev Genet 6:271–286

    Article  CAS  PubMed  Google Scholar 

  • Lynch M, Walsh B (1998) Genetics and analysis of quantitative traits. Sunderland, MA Sinauer

    Google Scholar 

  • Mackay TF (2001) The genetic architecture of quantitative traits. Ann Rev Genet 35:303–339

    Article  CAS  PubMed  Google Scholar 

  • Xu S, Atchley WR (1996) Mapping quantitative trait loci for complex binary diseases using line crosses. Genetics 143:1417–1424

    CAS  PubMed Central  PubMed  Google Scholar 

  • Zeng ZB (1994) Precision mapping of quantitative trait loci. Genetics 136:1457–1468

    CAS  PubMed Central  PubMed  Google Scholar 

Computer softwares

  • Broman KW, Wu H, Sen S, Churchill GA (2003) R/qtl: QTL mapping in experimental crosses. Bioinformatics 19:889–890

    Article  CAS  PubMed  Google Scholar 

  • Conover WJ, Iman RL (1981) Rank transformations as a bridge between parametric and nonparametric statistics. Am Stat 35:124–129

    Google Scholar 

  • GeneNetwork: http://www.genenetwork.org

  • Kruglyak L, Lander ES (1995) A nonparametric approach for mapping quantitative trait loci. Genetics 139:1421–1428

    CAS  PubMed Central  PubMed  Google Scholar 

  • Lander ES, Green P, Abrahamson J, Barlow A, Daly MJ, Lincoln SE, Newberg LA, Newburg L (1987) MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1:174–181

    Article  CAS  PubMed  Google Scholar 

  • Sen S, Churchill GA (2001) A statistical framework for quantitative trait mapping. Genetics 159:371–387

    CAS  PubMed Central  PubMed  Google Scholar 

Download references

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Correspondence to Jean-Louis Guénet .

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Guénet, JL., Benavides, F., Panthier, JJ., Montagutelli, X. (2015). Quantitative Traits and Quantitative Genetics. In: Genetics of the Mouse. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44287-6_10

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