Genetics of the Mouse

  • Jean Louis Guénet
  • Fernando Benavides
  • Jean-Jacques Panthier
  • Xavier Montagutelli

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Jean-Louis Guénet, Fernando Benavides, Jean-Jacques Panthier, Xavier Montagutelli
    Pages 1-17
  3. Jean-Louis Guenet, Fernando Benavides, Jean-Jacques Panthier, Xavier Montagutelli
    Pages 19-49
  4. Jean-Louis Guenet, Fernando Benavides, Jean-Jacques Panthier, Xavier Montagutelli
    Pages 51-88
  5. Jean-Louis Guenet, Fernando Benavides, Jean-Jacques Panthier, Xavier Montagutelli
    Pages 89-125
  6. Jean-Louis Guenet, Fernando Benavides, Jean-Jacques Panthier, Xavier Montagutelli
    Pages 127-185
  7. Jean-Louis Guénet, Fernando Benavides, Jean-Jacques Panthier, Xavier Montagutelli
    Pages 187-220
  8. Jean-Louis Guénet, Fernando Benavides, Jean-Jacques Panthier, Xavier Montagutelli
    Pages 221-265
  9. Jean-Louis Guénet, Fernando Benavides, Jean-Jacques Panthier, Xavier Montagutelli
    Pages 267-317
  10. Jean-Louis Guénet, Fernando Benavides, Jean-Jacques Panthier, Xavier Montagutelli
    Pages 319-359
  11. Jean-Louis Guénet, Fernando Benavides, Jean-Jacques Panthier, Xavier Montagutelli
    Pages 361-388
  12. Back Matter
    Pages 389-408

About this book

Introduction

This book, written by experienced geneticists, covers topics ranging from the natural history of the mouse species, its handling and reproduction in the laboratory, and its classical genetics and cytogenetics, to modern issues including the analysis of the transcriptome, the parental imprinting and X-chromosome inactivation. The strategies for creating all sorts of mutations, either by genetic engineering or by using mutagens, are also reviewed and discussed in detail. Finally, a last chapter outlines the methodology used for the analysis of complex or quantitative traits.

 

The authors also discuss the importance of accurate phenotyping, which is now performed in the mouse clinics established worldwide and identify the limits of the mouse model, which under certain circumstances can fail to present the phenotype expected from the cognate condition in the human model. For each chapter an up-to-date list of pertinent references is provided.

 

In short, this book offers an essential resource for all scientists who use or plan to use mice in their research.

Keywords

animal models mouse genetics mutagenesis rodent genetics trangenesis

Authors and affiliations

  • Jean Louis Guénet
    • 1
  • Fernando Benavides
    • 2
  • Jean-Jacques Panthier
    • 3
  • Xavier Montagutelli
    • 4
  1. 1.Institut PasteurParisFrance
  2. 2.Department of Molecular Carcinogenesis Division of Basic Science ResearchThe University of Texas MD Anderson Cancer CenterSmithvilleUSA
  3. 3.Mouse Functional Genetics UnitInstitut PasteurParisFrance
  4. 4.Mouse Functional Genetics UnitInstitut PasteurParisFrance

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-662-44287-6
  • Copyright Information Springer-Verlag Berlin Heidelberg 2015
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-662-44286-9
  • Online ISBN 978-3-662-44287-6
  • About this book