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Infection Control and Hospital Epidemiology in Hematology Units

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Infections in Hematology
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Abstract

Hematological patients in aplasia after induction/consolidation chemotherapy or conditioning regimen for hematological stem cell transplantation are at high risk for infectious complications with endogenous or hospital-acquired bacteria, fungi, and viruses. Infection control aims at preventing exposure of these patients with infectious agents in the hospital environment during the most vulnerable phase of neutropenia. Protective care with nursing in positive pressure single rooms supplied with HEPA-filtered air is recommended. Adequate cleaning of the environment; precaution measures during construction works; monitoring of air and water for molds; instructions for healthcare workers, patients, and visitors; and special preparation of nutrition are addressed.

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References

  1. Anaissie EJ, Stratton SL, Dignani MC, Lee CK, Summerbell RC, Rex JH, Monson TP, Walsh TJ. Pathogenic molds (including Aspergillus species) in hospital water distribution systems: a 3-year prospective study and clinical implications for patients with hematologic malignancies. Blood. 2003;101:2542–6.

    Article  CAS  PubMed  Google Scholar 

  2. Anaissie EJ, Stratton SL, Dignani MC, Summerbell RC, Rex JH, Monson TP, Spencer T, Kasai M, Francesconi A, Walsh TJ. Pathogenic Aspergillus species recovered from a hospital water system: a 3-year prospective study. Clin Infect Dis. 2002;34:780–9.

    Article  PubMed  Google Scholar 

  3. Appelbaum FR. Hematopoietic-cell transplantation at 50. N Engl J Med. 2007;357:1472–5.

    Article  CAS  PubMed  Google Scholar 

  4. Balduzzi A, Lucchini G, Hirsch HH, Basso S, Cioni M, Rovelli A, Zincone A, Grimaldi M, Corti P, Bonanomi S, Biondi A, Locatelli F, Biagi E, Comoli P. Polyomavirus JC-targeted T-cell therapy for progressive multiple leukoencephalopathy in a hematopoietic cell transplantation recipient. Bone Marrow Transplant. 2011;46(7):987–92.

    Google Scholar 

  5. Berrouane YF, McNutt LA, Buschelman BJ, Rhomberg PR, Sanford MD, Hollis RJ, Pfaller MA, Herwaldt LA. Outbreak of severe Pseudomonas aeruginosa infections caused by a contaminated drain in a whirlpool bathtub. Clin Infect Dis. 2000;31:1331–7.

    Article  CAS  PubMed  Google Scholar 

  6. Bodey GP, Buckley M, Sathe YS, Freireich EJ. Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia. Ann Intern Med. 1966;64:328–40.

    Article  CAS  PubMed  Google Scholar 

  7. Bolyard EA, Tablan OC, Williams WW, Pearson ML, Shapiro CN, Deitchmann SD. Guideline for infection control in healthcare personnel, 1998. Hospital Infection Control Practices Advisory Committee. Infect Control Hosp Epidemiol. 1998;19:407–63.

    Article  CAS  PubMed  Google Scholar 

  8. Boyce JM. Environmental contamination makes an important contribution to hospital infection. J Hosp Infect. 2007;65 Suppl 2:50–4.

    Article  PubMed  Google Scholar 

  9. Boyce JM, Havill NL, Otter JA, McDonald LC, Adams NM, Cooper T, Thompson A, Wiggs L, Killgore G, Tauman A, Noble-Wang J. Impact of hydrogen peroxide vapor room decontamination on Clostridium difficile environmental contamination and transmission in a healthcare setting. Infect Control Hosp Epidemiol. 2008;29:723–9.

    Article  PubMed  Google Scholar 

  10. Boyce JM, Ligi C, Kohan C, Dumigan D, Havill NL. Lack of association between the increased incidence of Clostridium difficile-associated disease and the increasing use of alcohol-based hand rubs. Infect Control Hosp Epidemiol. 2006;27:479–83.

    Article  PubMed  Google Scholar 

  11. Boyce JM, Pittet D. Guideline for hand hygiene in health-care settings. Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force. Society for Healthcare Epidemiology of America/Association for Professionals in Infection Control/Infectious Diseases Society of America. MMWR Recomm Rep. 2002;51:1–45, quiz CE1-4.

    PubMed  Google Scholar 

  12. Buehlmann M, Frei R, Fenner L, Dangel M, Fluckiger U, Widmer AF. Highly effective regimen for decolonization of methicillin-resistant Staphylococcus aureus carriers. Infect Control Hosp Epidemiol. 2008;29:510–6.

    Article  CAS  PubMed  Google Scholar 

  13. Buttery JP, Alabaster SJ, Heine RG, Scott SM, Crutchfield RA, Bigham A, Tabrizi SN, Garland SM. Multiresistant Pseudomonas aeruginosa outbreak in a pediatric oncology ward related to bath toys. Pediatr Infect Dis J. 1998;17:509–13.

    Article  CAS  PubMed  Google Scholar 

  14. Cantoni N, Weisser M, Buser A, Arber C, Stern M, Heim D, Halter J, Christen S, Tsakiris DA, Droll A, Frei R, Widmer AF, Fluckiger U, Passweg J, Tichelli A, Gratwohl A. Infection prevention strategies in a stem cell transplant unit: impact of change of care in isolation practice and routine use of high dose intravenous immunoglobulins on infectious complications and transplant related mortality. Eur J Haematol. 2009;83:130–8.

    Article  CAS  PubMed  Google Scholar 

  15. Cartman ST, Heap JT, Kuehne SA, Cockayne A, Minton NP. The emergence of ‘hypervirulence’ in Clostridium difficile. Int J Med Microbiol. 2010;300:387–95.

    Article  PubMed  Google Scholar 

  16. Cesaro S, Chinello P, Rossi L, Zanesco L. Saccharomyces cerevisiae fungemia in a neutropenic patient treated with Saccharomyces boulardii. Support Care Cancer. 2000;8:504–5.

    Article  CAS  PubMed  Google Scholar 

  17. Chaberny IF, Ruseva E, Sohr D, Buchholz S, Ganser A, Mattner F, Gastmeier P. Surveillance with successful reduction of central line-associated bloodstream infections among neutropenic patients with hematologic or oncologic malignancies. Ann Hematol. 2009;88:907–12.

    Article  PubMed  Google Scholar 

  18. Conen A, Zimmerer S, Trampuz A, Frei R, Battegay M, Elzi L. A pain in the neck: probiotics for ulcerative colitis. Ann Intern Med. 2009;151:895–7.

    Article  PubMed  Google Scholar 

  19. Cornet M, Levy V, Fleury L, Lortholary J, Barquins S, Coureul MH, Deliere E, Zittoun R, Brucker G, Bouvet A. Efficacy of prevention by high-efficiency particulate air filtration or laminar airflow against Aspergillus airborne contamination during hospital renovation. Infect Control Hosp Epidemiol. 1999;20:508–13.

    Article  CAS  PubMed  Google Scholar 

  20. de Kraker ME, Wolkewitz M, Davey PG, Grundmann H. The clinical impact of antimicrobial resistance in European hospitals: excess mortality and length of hospital stay related to methicillin resistant Staphylococcus aureus bloodstream infections. Antimicrob Agents Chemother. 2011;55(4):1598–605.

    Google Scholar 

  21. de Regt MJ, van der Wagen LE, Top J, Blok HE, Hopmans TE, Dekker AW, Hene RJ, Siersema PD, Willems RJ, Bonten MJ. High acquisition and environmental contamination rates of CC17 ampicillin-resistant Enterococcus faecium in a Dutch hospital. J Antimicrob Chemother. 2008;62:1401–6.

    Article  PubMed  Google Scholar 

  22. Dettenkofer M, Wenzler S, Amthor S, Antes G, Motschall E, Daschner FD. Does disinfection of environmental surfaces influence nosocomial infection rates? A systematic review. Am J Infect Control. 2004;32:84–9.

    Article  PubMed  Google Scholar 

  23. Diab-Elschahawi M, Furnkranz U, Blacky A, Bachhofner N, Koller W. Re-evaluation of current A0 value recommendations for thermal disinfection of reusable human waste containers based on new experimental data. J Hosp Infect. 2010;75:62–5.

    Article  CAS  PubMed  Google Scholar 

  24. Dietrich M, Gaus W, Vossen J, van der Waaij D, Wendt F. Protective isolation and antimicrobial decontamination in patients with high susceptibility to infection. A prospective cooperative study of gnotobiotic care in acute leukemia patients. I: clinical results. Infection. 1977;5:107–14.

    Article  CAS  PubMed  Google Scholar 

  25. Elting LS, Whimbey E, Lo W, Couch R, Andreeff M, Bodey GP. Epidemiology of influenza A virus infection in patients with acute or chronic leukemia. Support Care Cancer. 1995;3:198–202.

    Article  CAS  PubMed  Google Scholar 

  26. Engelhart S, Hanfland J, Glasmacher A, Krizek L, Schmidt-Wolf IG, Exner M. Impact of portable air filtration units on exposure of haematology-oncology patients to airborne Aspergillus fumigatus spores under field conditions. J Hosp Infect. 2003;54:300–4.

    Article  CAS  PubMed  Google Scholar 

  27. Falagas ME, Rafailidis PI, Kofteridis D, Virtzili S, Chelvatzoglou FC, Papaioannou V, Maraki S, Samonis G, Michalopoulos A. Risk factors of carbapenem-resistant Klebsiella pneumoniae infections: a matched case control study. J Antimicrob Chemother. 2007;60:1124–30.

    Article  CAS  PubMed  Google Scholar 

  28. Gardner A, Mattiuzzi G, Faderl S, Borthakur G, Garcia-Manero G, Pierce S, Brandt M, Estey E. Randomized comparison of cooked and noncooked diets in patients undergoing remission induction therapy for acute myeloid leukemia. J Clin Oncol. 2008;26:5684–8.

    Article  PubMed  Google Scholar 

  29. Gerding DN, Johnson S, Peterson LR, Mulligan ME, Silva Jr J. Clostridium difficile-associated diarrhea and colitis. Infect Control Hosp Epidemiol. 1995;16:459–77.

    Article  CAS  PubMed  Google Scholar 

  30. Gillies D, O’Riordan L, Carr D, Frost J, Gunning R, O’Brien I. Gauze and tape and transparent polyurethane dressings for central venous catheters. Cochrane Database Syst Rev. 2003;(4):CD003827.

    Google Scholar 

  31. Gratwohl A, Brand R, Frassoni F, Rocha V, Niederwieser D, Reusser P, Einsele H, Cordonnier C. Cause of death after allogeneic haematopoietic stem cell transplantation (HSCT) in early leukaemias: an EBMT analysis of lethal infectious complications and changes over calendar time. Bone Marrow Transplant. 2005;36:757–69.

    Article  CAS  PubMed  Google Scholar 

  32. Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. MMWR Recomm Rep. 2000;49:1–125, CE1-7.

    Google Scholar 

  33. Gupta A, Della-Latta P, Todd B, San Gabriel P, Haas J, Wu F, Rubenstein D, Saiman L. Outbreak of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit linked to artificial nails. Infect Control Hosp Epidemiol. 2004;25:210–5.

    Article  PubMed  Google Scholar 

  34. Hasman H, Mevius D, Veldman K, Olesen I, Aarestrup FM. beta-Lactamases among extended-spectrum beta-lactamase (ESBL)-resistant Salmonella from poultry, poultry products and human patients in The Netherlands. J Antimicrob Chemother. 2005;56:115–21.

    Article  CAS  PubMed  Google Scholar 

  35. Herrmann RP, Trent M, Cooney J, Cannell PK. Infections in patients managed at home during autologous stem cell transplantation for lymphoma and multiple myeloma. Bone Marrow Transplant. 1999;24:1213–7.

    Article  CAS  PubMed  Google Scholar 

  36. Hirsch HH, Knowles W, Dickenmann M, Passweg J, Klimkait T, Mihatsch MJ, Steiger J. Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients. N Engl J Med. 2002;347:488–96.

    Article  PubMed  Google Scholar 

  37. Hota B, Blom DW, Lyle EA, Weinstein RA, Hayden MK. Interventional evaluation of environmental contamination by vancomycin-resistant enterococci: failure of personnel, product, or procedure? J Hosp Infect. 2009;71:123–31.

    Article  CAS  PubMed  Google Scholar 

  38. Jacoby GA. AmpC beta-lactamases. Clin Microbiol Rev. 2009;22:161–82, table of contents.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  39. Johnson S, Gerding DN. Clostridium difficile – associated diarrhea. Clin Infect Dis. 1998;26:1027–34; quiz 1035–6.

    Article  CAS  PubMed  Google Scholar 

  40. Kanda Y, Yamamoto R, Chizuka A, Hamaki T, Suguro M, Arai C, Matsuyama T, Takezako N, Miwa A, Kern W, Kami M, Akiyama H, Hirai H, Togawa A. Prophylactic action of oral fluconazole against fungal infection in neutropenic patients. A meta-analysis of 16 randomized, controlled trials. Cancer. 2000;89:1611–25.

    Article  CAS  PubMed  Google Scholar 

  41. Khanna N, Widmer AF, Decker M, Steffen I, Halter J, Heim D, Weisser M, Gratwohl A, Fluckiger U, Hirsch HH. Respiratory syncytial virus infection in patients with hematological diseases: single-center study and review of the literature. Clin Infect Dis. 2008;46:402–12.

    Article  CAS  PubMed  Google Scholar 

  42. Kluytmans JA. Methicillin-resistant Staphylococcus aureus in food products: cause for concern or case for complacency? Clin Microbiol Infect. 2010;16:11–5.

    Article  CAS  PubMed  Google Scholar 

  43. Kool JL, Fiore AE, Kioski CM, Brown EW, Benson RF, Pruckler JM, Glasby C, Butler JC, Cage GD, Carpenter JC, Mandel RM, England B, Breiman RF. More than 10 years of unrecognized nosocomial transmission of legionnaires’ disease among transplant patients. Infect Control Hosp Epidemiol. 1998;19:898–904.

    Article  CAS  PubMed  Google Scholar 

  44. Loeb M, Dafoe N, Mahony J, John M, Sarabia A, Glavin V, Webby R, Smieja M, Earn DJ, Chong S, Webb A, Walter SD. Surgical mask vs N95 respirator for preventing influenza among health care workers: a randomized trial. JAMA. 2009;302:1865–71.

    Article  CAS  PubMed  Google Scholar 

  45. Maki DG, Stolz SM, Wheeler S, Mermel LA. Prevention of central venous catheter-related bloodstream infection by use of an antiseptic-impregnated catheter. A randomized, controlled trial. Ann Intern Med. 1997;127:257–66.

    Article  CAS  PubMed  Google Scholar 

  46. Manoloff ES, Francioli P, Taffe P, Van Melle G, Bille J, Hauser PM. Risk for Pneumocystis carinii transmission among patients with pneumonia: a molecular epidemiology study. Emerg Infect Dis. 2003;9:132–4.

    Article  PubMed Central  PubMed  Google Scholar 

  47. Maschmeyer G, Neuburger S, Fritz L, Bohme A, Penack O, Schwerdtfeger R, Buchheidt D, Ludwig WD. A prospective, randomised study on the use of well-fitting masks for prevention of invasive aspergillosis in high-risk patients. Ann Oncol. 2009;20:1560–4.

    Article  CAS  PubMed  Google Scholar 

  48. Mertz D, Frei R, Periat N, Zimmerli M, Battegay M, Fluckiger U, Widmer AF. Exclusive Staphylococcus aureus throat carriage: at-risk populations. Arch Intern Med. 2009;169:172–8.

    Article  PubMed  Google Scholar 

  49. Moreno A, Cervera C, Gavalda J, Rovira M, de la Camara R, Jarque I, Montejo M, de la Torre-Cisneros J, Miguel Cisneros J, Fortun J, Lopez-Medrano F, Gurgui M, Munoz P, Ramos A, Carratala J. Bloodstream infections among transplant recipients: results of a nationwide surveillance in Spain. Am J Transplant. 2007;7:2579–86.

    Article  CAS  PubMed  Google Scholar 

  50. Muto CA, Jernigan JA, Ostrowsky BE, Richet HM, Jarvis WR, Boyce JM, Farr BM. SHEA guideline for preventing nosocomial transmission of multidrug-resistant strains of Staphylococcus aureus and enterococcus. Infect Control Hosp Epidemiol. 2003;24:362–86.

    Article  PubMed  Google Scholar 

  51. Nauseef WM, Maki DG. A study of the value of simple protective isolation in patients with granulocytopenia. N Engl J Med. 1981;304:448–53.

    Article  CAS  PubMed  Google Scholar 

  52. Nihtinen A, Anttila VJ, Richardson M, Meri T, Volin L, Ruutu T. The utility of intensified environmental surveillance for pathogenic moulds in a stem cell transplantation ward during construction work to monitor the efficacy of HEPA filtration. Bone Marrow Transplant. 2007;40:457–60.

    Article  CAS  PubMed  Google Scholar 

  53. Nordmann P, Poirel L, Carrer A, Toleman MA, Walsh TR. How to detect NDM-1 producers. J Clin Microbiol. 2011;49:718–21.

    Article  PubMed Central  PubMed  Google Scholar 

  54. O’Grady NP, Alexander M, Dellinger EP, Gerberding JL, Heard SO, Maki DG, Masur H, McCormick RD, Mermel LA, Pearson ML, Raad II, Randolph A, Weinstein RA. Guidelines for the prevention of intravascular catheter-related infections. Centers for disease control and prevention. MMWR Recomm Rep. 2002;51:1–29.

    PubMed  Google Scholar 

  55. Opal SM, Asp AA, Cannady Jr PB, Morse PL, Burton LJ, Hammer 2nd PG. Efficacy of infection control measures during a nosocomial outbreak of disseminated aspergillosis associated with hospital construction. J Infect Dis. 1986;153:634–7.

    Article  CAS  PubMed  Google Scholar 

  56. Oren I, Zuckerman T, Avivi I, Finkelstein R, Yigla M, Rowe JM. Nosocomial outbreak of Legionella pneumophila serogroup 3 pneumonia in a new bone marrow transplant unit: evaluation, treatment and control. Bone Marrow Transplant. 2002;30:175–9.

    Article  CAS  PubMed  Google Scholar 

  57. Overdevest IT, Willemsen I, Elberts S, Verhulst C, Kluytmans JA. Laboratory detection of extended-spectrum-beta-lactamase-producing Enterobacteriaceae: evaluation of two screening agar plates and two confirmation techniques. J Clin Microbiol. 2011;49:519–22.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  58. Petersen F, Thornquist M, Buckner C, Counts G, Nelson N, Meyers J, Clift R, Thomas E. The effects of infection prevention regimens on early infectious complications in marrow transplant patients: a four arm randomized study. Infection. 1988;16:199–208.

    Article  CAS  PubMed  Google Scholar 

  59. Pronovost P, Needham D, Berenholtz S, Sinopoli D, Chu H, Cosgrove S, Sexton B, Hyzy R, Welsh R, Roth G, Bander J, Kepros J, Goeschel C. An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med. 2006;355:2725–32.

    Article  CAS  PubMed  Google Scholar 

  60. Recommendations for preventing the spread of vancomycin resistance. Recommendations of the Hospital Infection Control Practices Advisory Committee (HICPAC). MMWR Recomm Rep. 1995;44:1–13.

    Google Scholar 

  61. Robicsek A, Beaumont JL, Paule SM, Hacek DM, Thomson Jr RB, Kaul KL, King P, Peterson LR. Universal surveillance for methicillin-resistant in 3 affiliated hospitals. Ann Intern Med. 2008;148:409–18.

    Article  PubMed  Google Scholar 

  62. Rutala WA. APIC guideline for selection and use of disinfectants. 1994, 1995, and 1996 APIC Guidelines Committee. Association for Professionals in Infection Control and Epidemiology, Inc. Am J Infect Control. 1996;24:313–42.

    Article  CAS  PubMed  Google Scholar 

  63. Sehulster L, Chinn RY. Guidelines for environmental infection control in health-care facilities. Recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee (HICPAC). MMWR Recomm Rep. 2003;52:1–42.

    PubMed  Google Scholar 

  64. Siegel JD, Rhinehart E, Jackson M, Chiarello L. 2007 Guideline for isolation precautions: preventing transmission of infectious agents in health care settings. Am J Infect Control. 2007;35:S65–164.

    Article  PubMed  Google Scholar 

  65. Skopinska E. Some effects of Escherichia coli endotoxin on the graft-versus-host reaction in mice. Transplantation. 1972;14:432–7.

    Article  CAS  PubMed  Google Scholar 

  66. Stevens DA, Lee JY. Analysis of compassionate use itraconazole therapy for invasive aspergillosis by the NIAID Mycoses Study Group criteria. Arch Intern Med. 1997;157:1857–62.

    Article  CAS  PubMed  Google Scholar 

  67. Svahn BM, Bjurman B, Myrback KE, Aschan J, Ringden O. Is it safe to treat allogeneic stem cell transplant recipients at home during the pancytopenic phase? A pilot trial. Bone Marrow Transplant. 2000;26:1057–60.

    Article  CAS  PubMed  Google Scholar 

  68. Svahn BM, Remberger M, Myrback KE, Holmberg K, Eriksson B, Hentschke P, Aschan J, Barkholt L, Ringden O. Home care during the pancytopenic phase after allogeneic hematopoietic stem cell transplantation is advantageous compared with hospital care. Blood. 2002;100:4317–24.

    Article  CAS  PubMed  Google Scholar 

  69. Tablan OC, Anderson LJ, Besser R, Bridges C, Hajjeh R. Guidelines for preventing health-care–associated pneumonia, 2003: recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee. MMWR Recomm Rep. 2004;53:1–36.

    PubMed  Google Scholar 

  70. Tietz A, Frei R, Dangel M, Bolliger D, Passweg JR, Gratwohl A, Widmer AE. Octenidine hydrochloride for the care of central venous catheter insertion sites in severely immunocompromised patients. Infect Control Hosp Epidemiol. 2005;26:703–7.

    Article  PubMed  Google Scholar 

  71. Tomblyn M, Chiller T, Einsele H, Gress R, Sepkowitz K, Storek J, Wingard JR, Young JA, Boeckh MJ. Guidelines for preventing infectious complications among hematopoietic cell transplantation recipients: a global perspective. Biol Blood Marrow Transplant. 2009;15:1143–238.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  72. Tschudin Sutter S, Frei R, Dangel M, Gratwohl A, Bonten M, Widmer AF. Not all patients with vancomycin-resistant enterococci need to be isolated. Clin Infect Dis. 2010;51:678–83.

    Article  CAS  PubMed  Google Scholar 

  73. Tschudin-Sutter S, Pargger H, Widmer AF. Hand hygiene in the intensive care unit. Crit Care Med. 2010;38:S299–305.

    Article  PubMed  Google Scholar 

  74. Vonberg RP, Gastmeier P. Nosocomial aspergillosis in outbreak settings. J Hosp Infect. 2006;63:246–54.

    Article  PubMed  Google Scholar 

  75. Wassenberg MW, Kluytmans JA, Box AT, Bosboom RW, Buiting AG, Van Elzakker EP, Melchers WJ, Van Rijen MM, Thijsen SF, Troelstra A, Vandenbroucke-Grauls CM, Visser CE, Voss A, Wolffs PF, Wulf MW, Van Zwet AA, De Wit GA, Bonten MJ. Rapid screening of methicillin-resistant Staphylococcus aureus using PCR and chromogenic agar: a prospective study to evaluate costs and effects. Clin Microbiol Infect. 2010;16:1754–61.

    Article  CAS  PubMed  Google Scholar 

  76. Widmer AF. Replace hand washing with use of a waterless alcohol hand rub? Clin Infect Dis. 2000;31:136–43.

    Article  CAS  PubMed  Google Scholar 

  77. Widmer AF, Frei R. Decontamination, disinfection, sterilization. In: Baron EJ, Murray PR, Pfaller M, Tenover FC, Yolken R, editors. Manual of clinical microbiology. Washington: ASM Press; 2011. p. 138–64.

    Google Scholar 

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Weisser, M., Widmer, A. (2015). Infection Control and Hospital Epidemiology in Hematology Units. In: Maschmeyer, G., Rolston, K. (eds) Infections in Hematology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44000-1_17

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