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Preconditioning in the Human Heart: Fact or Fantasy?

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Myocardial Preconditioning

Part of the book series: Medical Intelligence Unit ((MIU.LANDES))

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Abstract

The routine management of acute myocardial infarction was revolutionized in the 1980s by the widespread introduction into clinical practice of safe and effective forms of reperfusion therapy. The central importance of reperfusion in any strategy for limiting infarct size has long been recognized in experimental studies. It was not, however, until several large clinical trials had demonstrated that thrombolysis could both achieve reperfusion and, more importantly, reduce mortality1,2 that such techniques became widely used. More recent studies have shown that direct balloon angioplasty of the acutely occluded coronary vessel has been shown to be even more effective,3–5 presumably due to reperfusion being achieved more rapidly and more reliably than with thrombolysis. Despite these major advances ischemic heart disease, in its various forms, is still responsible for more deaths in the developed world than any other disease process.

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Authors
  1. Clive S. Lawson
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© 1996 Springer-Verlag Berlin Heidelberg

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Lawson, C.S. (1996). Preconditioning in the Human Heart: Fact or Fantasy?. In: Myocardial Preconditioning. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22206-5_7

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  • DOI: https://doi.org/10.1007/978-3-662-22206-5_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22208-9

  • Online ISBN: 978-3-662-22206-5

  • eBook Packages: Springer Book Archive

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