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Cardioprotective Effects of Chronic Hypoxia: Relation to Preconditioning

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Myocardial Preconditioning

Part of the book series: Medical Intelligence Unit ((MIU.LANDES))

Abstract

Preconditioning with ischemia originally referred to the observation that brief sublethal coronary occlusions, each followed by reperfusion, limit the infarct size in dogs after a subsequent longer period of ischemia.1 Since then, this remarkable phenomenon has been demonstrated in a variety of experimental models and the concept of preconditioning broadened to include the temporal protection of the heart against other adverse consequences of ischemia and reperfusion, such as arrhythmias or contractile dysfunction. This term is now used to describe also the increased tolerance of the heart to various types of stress mediated by brief stimuli other than ischemia (e.g., acute hypoxia, drugs).2 Occasionally, preconditioning has been improperly used in a more general meaning that includes any intervention, even long-term, which increases the resistance of the heart against subsequent injury. As ischemic preconditioning represents the most efficient form of temporal protection, it has attracted a great deal of attention and considerable progress has been achieved in understanding this phenomenon over the past nine years. At the same time, however, other forms of protection have been largely ignored.

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  1. František Kolář
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© 1996 Springer-Verlag Berlin Heidelberg

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Kolář, F. (1996). Cardioprotective Effects of Chronic Hypoxia: Relation to Preconditioning. In: Myocardial Preconditioning. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22206-5_15

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  • DOI: https://doi.org/10.1007/978-3-662-22206-5_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22208-9

  • Online ISBN: 978-3-662-22206-5

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