Skip to main content

Mimicking Preconditioning with Catecholamines

  • Chapter
Myocardial Preconditioning

Part of the book series: Medical Intelligence Unit ((MIU.LANDES))

Abstract

The last decade has witnessed the development of a novel approach to myocardial protection against ischemia that exploits the heart’s own endogenous protective mechanisms. The concept of ischemic preconditioning has offered powerful new tools to combat the deleterious effects of long-lasting ischemia through adaptation of the heart by means of preceding, short episodes of the same ischemic stress. This short-term adaptive phenomenon is mediated by cell signaling mechanisms which open possibilities for pharmacological modulation at different levels of signal transduction (receptors, second messengers, effectors).1,2

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Das DK. Ischemic preconditioning and myocardial adaptation to ischemia. Cardiovasc Res 1993; 27: 2077–2079.

    Article  PubMed  CAS  Google Scholar 

  2. Banerjee A. Could the “real” preconditioning mechanism please stand up? (or, a polyplanic platitude to preconditioning). Cardiovasc Res 1994; 28: 1872–1873.

    Article  PubMed  CAS  Google Scholar 

  3. Parratt JR. Endogenous myocardial protective (antiarrhythmic) substances. Cardiovasc Res 1993; 27: 693–702.

    Article  PubMed  CAS  Google Scholar 

  4. Curtis MJ, Pugsley MK, Walker MJA. Endogenous chemical mediators of arrhythmogenesis in ischemic heart disease. Cardiovasc Res 1993; 27: 703–719.

    Article  PubMed  CAS  Google Scholar 

  5. Karlsberg RP, Cryer PE, Roberts R. Serial plasma carecholamine response early in the course of clinical acute myocardial infarction: relationship to infarct extent and mortality. Am Heart J 1988; 102: 24–29.

    Article  Google Scholar 

  6. Yamaguchi M, de Champlain J, Nadeau R. Correlation between the response of the heart to sympathetic stimulation and the release of endogenous catecholamines into the coronary sinus of the dog. Circ Res 1975; 36: 662–628.

    Article  PubMed  CAS  Google Scholar 

  7. Bertel O, Buhler FR, Baitsch G et al. Plasma adrenaline and noradrenaline in patients with acute myocardial infarction. Relationship to ventricular arrhythmias of varying sensitivity. Chest 1982; 82: 64–68.

    Article  PubMed  CAS  Google Scholar 

  8. Dart AM, Riemersma RA. Neurally mediated and spontaneous release of noradrenaline in the ischemic and reperfused rat heart. J Cardiovasc Pharmacol 1985; 7 (Suppl 5): 545–549.

    Google Scholar 

  9. Karlsberg RP, Penkoske PA, Cryer PE et al. Rapid activation of the sympathetic nervous system following coronary occlusion: relationship to infarct size site and hemodynamic impact. Cardiovasc Res 1979; 13: 523–531.

    Article  PubMed  CAS  Google Scholar 

  10. Knight DE. Calcium and exocytosis. Ciba Found Symp 1986; 122: 250–270.

    PubMed  CAS  Google Scholar 

  11. Dart AM. Influence of myocardial ischemia on exocytotic noradrenaline release. In: Brachman J, Schömig A, eds. Adrenergic system and ventricular arrhythmias in myocardial infarction. Berlin: Springer-Verlag 1989: 34–44.

    Chapter  Google Scholar 

  12. Dart AM, Dietz R, Hieronymus K et al. Effects of alpha and beta adrenoceptor blockade on the neurally evoked overflow of endogenous noradrenaline from the rat isolated heart. Br J Pharmacol 1984; 81: 475–478.

    Article  PubMed  CAS  Google Scholar 

  13. Forfar JC, Riemersma RA. Metabolic modulation of cardiac neuro-sympathetic activity in vivo: effects of potassium and adenosine. Cardiovasc Res 1987; 21: 821–829.

    Article  PubMed  CAS  Google Scholar 

  14. Hedqvist P. Basic mechanisms of prostaglandin action on autonomic neurotransmission. Ann Rev Pharmacol Toxicol 1977; 17: 259–279.

    Article  CAS  Google Scholar 

  15. Schömig A. Increase of cardiac and systemic catecholamines in myocardial ischemia. In: Brachman J, Schömig A, eds. Adrenergic system and ventricular arrhythmias in myocardial infarction. Berlin: Springer-Verlag 1989: 61–77.

    Chapter  Google Scholar 

  16. Schömig A, Fischer S, Kurz T et al. Nonexocytotic release of endogenous noradrenaline in the ischemic and anoxic rat heart: mechanism and metabolic requirements. Circ Res 1987; 60: 194–205.

    Article  PubMed  Google Scholar 

  17. Graefe K-H. On the mechanism of nonexocytotic release of noradrenaline from noradrenergic neurons. In: Brachman J, Schömig A, eds. Adrenergic system and ventricular arrhythmias in myocardial infarction. Berlin: Springer-Verlag 1989: 44–53.

    Chapter  Google Scholar 

  18. Fleming JW, Wisler PL, Watanabe AM. Signal transduction by G proteins in cardiac tissues. Circulation 1992; 85: 419–433.

    Article  Google Scholar 

  19. Tada M, Katz AM. Phosphorylation of the sarcoplasmatic reticulum and sarcolemma. Ann Rev Physiol 1982; 44: 401–423.

    Article  CAS  Google Scholar 

  20. Fedelesova M, Ziegelhoeffer A. Enhanced calcium accumulation related to increased protein phosphorylation in cardiac sarcoplasmic reticulum induced by cyclic 3’,5’-AMP or isoproterenol. Experientia 1975; 31: 518–520.

    Article  CAS  Google Scholar 

  21. Kohl C, Schmitz W, Scholz H et al. Evidence for a1-adrenoceptor-mediated increase of inositol triphosphate in the human heart. J Cardiovasc Pharmacol 1989; 13: 324–327.

    Article  PubMed  CAS  Google Scholar 

  22. Presti CF, Scott BT, Jones LR. Identification of an endogenous protein kinase C activity and its intrinsic 15-kdalton substrate in purified canine cardiac sarcolemmal membrane. J Biol Chem 1985; 260: 13879–13889.

    PubMed  CAS  Google Scholar 

  23. Lindemann JP. a-Adrenegic stimulation of sarcolemmal protein phosphorylation and slow responses in intact myocardium. J Biol Chem 1986; 261: 4860–4867.

    Google Scholar 

  24. Hanem S, Gronas T, Holten T et al. Intracellular pH measured by 31P-NMR in isolated rat heart during alpha-1-adrenoceptor stimulation. J Mol Cell Cardiol 1994; 26: 669–674.

    Article  PubMed  CAS  Google Scholar 

  25. Jiang JP, Downing SE. Catecholamine cardiomyopathy: review and analysis of pathogenetic mechanisms. Yale J Biol Med 1990; 63: 581–591.

    PubMed  CAS  Google Scholar 

  26. Martins JB, Zipes DP. Effects of sympathetic and vagal nerves on recovery properties of the endocardium and epicardium of the canine left ventricle. Circ Res 1980; 46: 100–110.

    Article  PubMed  CAS  Google Scholar 

  27. Tanabe T, Takahashi K, Kitada M et al. Effects of sympathetic stimulation, with and without previous a1 and ß adrenoceptor blockade, on refractoriness dispersion in canine heart. Cardiovasc Res 1994; 28: 1787–1793.

    Article  PubMed  CAS  Google Scholar 

  28. Cable DG, Rath TE, Dreyer ER et al. Refractory period response of cardiac Purkinje tissue to al-and a2-adrenergic influences. Am J Physiol 1994; 267: H376 - H382.

    PubMed  CAS  Google Scholar 

  29. Wendt DJ, Martins JB. Autonomic neural regulation of intact Purkinje system of dogs. Am J Physiol 1990; 258: H1420 - H1426.

    PubMed  CAS  Google Scholar 

  30. Benfey BG. Antifibrillatory effects of a1-adrenoceptor blocking drugs in experimental coronary artery occlusion and reperfusion. Can J Physiol Pharmacol 1993; 71: 103–111.

    Article  PubMed  CAS  Google Scholar 

  31. Rona G. Catecholamine cardiotoxicity. J Mol Cell Cardiol 1985; 17: 291–306.

    Article  PubMed  CAS  Google Scholar 

  32. Penny WJ. The deleterious effects of myocardial catecholamines on cellular electrophysiology and arrhythmias during ischemia and reperfusion. Eur Heart J 1984; 5: 960–973.

    PubMed  CAS  Google Scholar 

  33. Sheridan DJ, Penkoske PA, Sobel BE et al. Alpha adrenergic contributions to dysrhythmia during myocardial ischemia and reperfusion in cats. J Clin Invest 1988; 65: 161–171.

    Article  Google Scholar 

  34. Yusuf S, Petro R, Lewis J et al. Beta blockade during and after myocardial infarction: an overview of the randomized trials. Prog Cardiovasc Dis 1985; 27: 335–371.

    Article  PubMed  CAS  Google Scholar 

  35. Bril A, Rochette L. Comparison of the effect of antidepressant drugs on arrhythmias in the isolated rat heart subjected to myocardial ischemia and reperfusion. Pharmacol Toxicol 1987; 60: 249–254.

    Article  PubMed  CAS  Google Scholar 

  36. Dietz R, Offner B, Dart AM et al. Ischemia-induced noradrenaline release mediates ventricular arrhythmias. In: Brachman J, Schömig A, eds. Adrenergic system and ventricular arrhythmias in myocardial infarction. Berlin: Springer-Verlag 1989: 313–321.

    Chapter  Google Scholar 

  37. Curtis MJ, Boning JH, Hearse DJ et al. The sympathetic nervous system, catecholamines and ischemia-induced arrhythmias: dependence upon serum potassium concentration. In: Brachman J, Schömig A, eds. Adrenergic system and ventricular arrhythmias in myocardial infarction. Berlin: Springer-Verlag 1989: 205–219.

    Chapter  Google Scholar 

  38. Li HG, Jones DL, Yee R et al. Arrhythmogenic effects of catecholamines are decreased in heart failure induced by rapid pacing in dogs. Am J Physiol 1993; 265 (Heart Circ Physiol 34): H1654 - H1662.

    PubMed  CAS  Google Scholar 

  39. Janse MJ, Schwartz PJ, Wilms-Schopman F et al. Effects of unilateral stellate ganglion stimulation and ablation on electrophysiologic changes induced by acute myocardial ischemia in dogs. Circulation 1985; 72: 585–595.

    Article  PubMed  CAS  Google Scholar 

  40. Locke-Winter CR, Winter CB, Nelson DW et al. cAMP stimulation facilitates preconditioning against ischemia-reperfusion through norepinephrine and alphal mechanisms. Circulation 1991; 84 (Suppl II): II - 433 (Abstract).

    Google Scholar 

  41. Banerjee A, Locke-Winter C, Rogers KB et al. Preconditioning against myocardial dysfunction after ischemia and reperfusion by an a1-adrenergic mechanism. Circ Res 1993; 73: 656–670.

    Article  PubMed  CAS  Google Scholar 

  42. Asimakis GK, Inners-McBride K, Conti VR et al. Transient ß adrenergic stimulation can precondition the rat heart against postischemic contractile dysfunction. Cardiovasc Res 1994; 28: 1726–1734.

    Article  PubMed  CAS  Google Scholar 

  43. Kitakaze M, Hori M, Kamada T. Role of adenosine and its interaction with a adrenoceptor activity in ischemic and reperfusion injury of the myocardium. Cardiovasc Res 1993; 27: 18–27.

    Article  PubMed  CAS  Google Scholar 

  44. Weselcouch EO, Baird AJ, Sleph PG et al. Endogenous catecholamines are not necessary for ischemic preconditioning in the isolated perfused rat heart. Cardiovasc Res 1995; 29: 126–132.

    PubMed  CAS  Google Scholar 

  45. Thornton JD, Daly JF, Cohen MV et al. Catecholamines can induce adenosine receptor-mediated protection of the myocardium but do not participate in ischemic preconditioning in the rabbit. Circ Res 1993; 73: 649–655.

    Article  PubMed  CAS  Google Scholar 

  46. Ardell JL, Yang Xi-M, Thornton JD et al. Depletion of norepinephrine by chronic surgical sympathectomy does not block protection from ischemic preconditioning. Circulation 1994; 90: I - 108 (Abstract).

    Google Scholar 

  47. Toombs CF, Wiltse AL, Shebuski RJ. Ischemic preconditioning fails to limit infarct size in reserpinized rabbit myocardium: implication of norepinephrine release in the preconditioning effect. Circulation 1993; 88: 2351–2358.

    Article  PubMed  CAS  Google Scholar 

  48. Bankwala Z, Hale SL, Kloner RA. a-Adrenoceptor stimulation with exogenous norepinephrine or release of endogenous catecholamines mimics ischemic preconditioning. Circulation 1994; 90: 1023–1028.

    Article  PubMed  CAS  Google Scholar 

  49. Tsuchida A, Liu Y, Liu GS et al. Alpha 1-adrenergic agonists precondition rabbit ischemic myocardium independent of adenosine by direct activation of protin kinase C. Circ Res 1994; 75: 576–585.

    Article  PubMed  CAS  Google Scholar 

  50. Vegh A, Komori S, Szekeres L et al. Antiarrhythmic effects of preconditioning in anesthetized dogs and rats. Cardiovasc Res 1992; 26: 487–495.

    Article  PubMed  CAS  Google Scholar 

  51. Piacentini L, Wainwright CL, Parratt JR. The antiarrhythmic effect of ischemic preconditioning in isolated rat heart involves a pertussis toxin sensitive mechanism. Cardiovasc Res 1993; 27: 674–680.

    Article  PubMed  CAS  Google Scholar 

  52. Ravingerova T, Pyne NJ, Parratt JR. Adrenergic stimulation protects rat hearts against severe arrhythmias: relevance to ischemic preconditioning. J Mol Cell Cardiol 1994; 26: CXII (Abstract).

    Google Scholar 

  53. Parratt JR, Campbell C, Fagbemi O. Catecholamines and early post-infarction arrhythmias: the effects of a-and ß-adrenoceptor blockade. In: Delius W, Gerlach E, Grobecker H, Kübler W, eds. Catecholamines and the heart. Berlin: Springer-Verlag 1981: 269–284.

    Chapter  Google Scholar 

  54. Vegh A, Papp J Gy, Parratt JR. Intracoronary noradrenaline suppresses ischemia-induced ventricular arrhythmias in anesthetized dogs. J Mol Cell Cardiol 1994; 26: 100 (VII (Abstract).

    Google Scholar 

  55. Richard G, Blessing R, Schömig A. Cardiac noradrenaline release accelerates adenosine formation in the ischemic rat heart: role of neuronal noradrenaline carrier and adrenergic receptors. J Mol Cell Cardiol 1994; 26: 1321–1328.

    Article  Google Scholar 

  56. Winter CB, Mitchell MB, Locke-Winter CR et al. Adenosine induced preconditioning is dependent upon a1-adrenoreceptor activation. Circulation 1992; 86 (Suppl I): I - 25 (Abstract).

    Google Scholar 

  57. Asimakis GK, Inners-McBride K, Conti VR. Attenuation of postischemic dysfunction by ischemic preconditioning is not mediated by adenosine in the isolated rat heart. Cardiovasc Res 1993; 27: 1522–1530.

    Article  PubMed  CAS  Google Scholar 

  58. Lasley RD, Mentzer RM. Pertussis toxin blocks adenosine A,-receptor mediated protection of the ischemic heart. J Mol Cell Cardiol 1993; 25: 815–821.

    Article  PubMed  CAS  Google Scholar 

  59. Ravingerova T, Pyne NJ, Parratt JR. Ischemic preconditioning in the rat heart: the role of cell signaling. Physiol Res 1994; 43: 10P (Abstract).

    Google Scholar 

  60. Ravingerova T, Pyne NJ, Parratt JR. Ischemic preconditioning in the rat heart: the role of G-proteins and adrenergic stimulation. Mol Cell Biochemistry 1995; 147: 123–128.

    Article  CAS  Google Scholar 

  61. Hu K, Nattel S. Signal transduction systems underlying ischemic preconditioning in rat hearts. Circulation 1994; 90: I - 108 (Abstract).

    Google Scholar 

  62. Wilde AAM, Peters RJG, Janse MJ. Catecholamine release and potassium accumulation in the isolated globally ischemic rabbit heart. J Mol Cell Cardiol 1988; 20: 887–896.

    Article  PubMed  CAS  Google Scholar 

  63. Haag M, Gevers W, Bohmer RG. The interaction between calcium and the activation of Na, K’-ATPase by noradrenaline. Mol Cell Biochemistry 1985; 66: 111–116.

    CAS  Google Scholar 

  64. Bers DM, Lederer WJ, Berlin JR. Intracellular Ca transients in rat cardiac myocytes: role of Na-Ca exchange in excitation-contraction coupling. Am J Physiol; 258: C944 - C954.

    Google Scholar 

  65. Avkiran M, Haddock P, Ibuki C. Antifibrillatory effect of transient acidic reperfusion: role of Na`/K’ ATPase activity. J Mol Cell Cardiol 1994; 26: CVII (Abstract).

    Google Scholar 

  66. Janse MJ. The premature beat. Cardiovasc Res 1992; 26: 89–100.

    Article  PubMed  CAS  Google Scholar 

  67. Nayler WG, Panagiotopoulos S, Elz JS et al. Calcium mediated damage during post-ischemic reperfusion. J Mol Cell Cardiol 1988; 20 (suppl II): 41–54.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Ravingerová, T. (1996). Mimicking Preconditioning with Catecholamines. In: Myocardial Preconditioning. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22206-5_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-22206-5_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22208-9

  • Online ISBN: 978-3-662-22206-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics