Abstract
The last decade has witnessed the development of a novel approach to myocardial protection against ischemia that exploits the heart’s own endogenous protective mechanisms. The concept of ischemic preconditioning has offered powerful new tools to combat the deleterious effects of long-lasting ischemia through adaptation of the heart by means of preceding, short episodes of the same ischemic stress. This short-term adaptive phenomenon is mediated by cell signaling mechanisms which open possibilities for pharmacological modulation at different levels of signal transduction (receptors, second messengers, effectors).1,2
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Ravingerová, T. (1996). Mimicking Preconditioning with Catecholamines. In: Myocardial Preconditioning. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22206-5_10
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DOI: https://doi.org/10.1007/978-3-662-22206-5_10
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