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The Mitochondrial Genetic System

  • Chapter
Mitochondrial DNA Mutations in Aging, Disease and Cancer

Abstract

In this survey we present current views on the origin, evolution, maintenance and expression of the separate DNA genome inside mitochondria, that encodes a small subset of genes required for the functions of this organelle. Since the rest of this book is devoted to a description of the involvement of the mitochondrial genetic system (MGS) in human disease, we shall focus principally on human mitochondrial DNA (mtDNA). Notwithstanding, an enormous amount has been learned about mitochondrial function from studies in other organisms. Such model systems illuminate mechanisms that are very likely to operate in similar ways in humans and thereby provide a powerful paradigm to inform future research.

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  1. Howard T. Jacobs
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  2. Ian J. Holt
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  1. The Division of Experimental Therapeutics and Radiation Oncology, Johns Hopkins Oncology Center and Department of Environmental Health, Johns Hopkins School of Public Health, 600 N. Wolfe Street, Room 2-121, 21287, Baltimore, Maryland, USA

    Keshav K. Singh Ph.D.

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Jacobs, H.T., Holt, I.J. (1998). The Mitochondrial Genetic System. In: Singh, K.K. (eds) Mitochondrial DNA Mutations in Aging, Disease and Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-12509-0_3

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