Skip to main content
SpringerLink
Log in
Book cover

Mitochondrial DNA Mutations in Aging, Disease and Cancer

  • Book
  • © 1998

Overview

Editors:
  1. Keshav K. Singh

    1. The Division of Experimental Therapeutics and Radiation Oncology, Johns Hopkins Oncology Center and Department of Environmental Health, Johns Hopkins School of Public Health, Baltimore, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Most comprehensive, up-to-date analysis of the role of mitochondria in aging and diseases.

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (20 chapters)

  1. Front Matter

    Pages i-xx
    Download chapter PDF

  2. Introduction

    • Dongchon Kang, Koichiro Takeshige, Mutsuo Sekiguchi, Keshav K. Singh
    Pages 1-15

  3. Mitochondrial Structure, Function and Biogenesis

    • Alfred S. Lewin
    Pages 17-41

  4. The Mitochondrial Genetic System

    • Howard T. Jacobs, Ian J. Holt
    Pages 43-83

  5. Inheritance of Mitochondrial Mutations

    • C. William Birky Jr.
    Pages 85-99

  6. Mitochondrial DNA Replication

    • Kylie F. Keshav, Shonen Yoshida
    Pages 101-114

  7. Genetic Integrity of the Mitochondrial Genome

    • Lene Juel Rasmussen, Keshav K. Singh
    Pages 115-127

  8. Modeling Mitochondrial DNA Mutations

    • T. B. L. Kirkwood, A. Kowald
    Pages 129-145

  9. Mitochondrial Regulation of Apoptosis

    • Patrice X. Petit, Guido Kroemer
    Pages 147-165

  10. Characteristics of Mitochondrial DNA Diseases

    • Carlos T. Moraes
    Pages 167-184

  11. Nuclear Defects Affecting Mitochondrial Function

    • Brian H. Robinson
    Pages 185-204

  12. Mitochondrial DNA Mutations in Aging

    • Phillip Nagley, Chunfang Zhang
    Pages 205-238

  13. Mitochondrial DNA Mutations and Heart Disease

    • Takayuki Ozawa, Mika Hayakawa
    Pages 239-263

  14. Mitochondrial Dysfunction and Neurodegenerative Diseases

    • Michael Lin, M. Flint Beal
    Pages 265-296

  15. Toxin Induced Mitochondrial Dysfunction and Neurodegeneration

    • Mohammad I. Sabri
    Pages 297-317

  16. Perspectives on Mitochondria in Carcinogenesis

    • Brian Bandy, Allan J. Davison
    Pages 319-336

  17. The Mitochondrion as a Target for Cancer Chemotherapy

    • Josephine S. Modica-Napolitano
    Pages 337-344

  18. Prohibitin: Mitochondrial Tumor Suppressor Protein

    • J. K. McClung
    Pages 345-363

  19. Abnormal Growth and Male Sterility Associated with Mitochondrial DNA Rearrangements in Plants

    • Kathleen J. Newton, Susan J. Gabay-Laughnan
    Pages 365-381

  20. Mitochondrial Disorder and Migraine

    • K. M. A. Welch, Charles Flippen
    Pages 383-394
Back to top

Keywords

About this book

Many human genetic diseases associated with blood, brain, colon, ear, eye, heart, kidney, liver, muscle, and pancreas are caused by mutations in mitochondrial DNA. Mutations in DNA can result in defects of the electron transport complexes, intermediates of the tricarboxylic acid cycle and substrate transport. The clinical manifestation of these diseases often involves muscle and the nervous system. Mitochondrial DNA mutations have now been associated with aging as well as age-related degenerative diseases such as Parkinson's, Alzheimer's, and Huntington's diseases. Changes in structure, function, and a number of mitochondria play an important role in carcinogenesis. Furthermore, the role of mitochondria in the execution of programmed cell death or apoptosis has been recognized recently.

Editors and Affiliations

  • The Division of Experimental Therapeutics and Radiation Oncology, Johns Hopkins Oncology Center and Department of Environmental Health, Johns Hopkins School of Public Health, Baltimore, USA

    Keshav K. Singh

Bibliographic Information

  • Book Title: Mitochondrial DNA Mutations in Aging, Disease and Cancer

  • Editors: Keshav K. Singh

  • DOI: https://doi.org/10.1007/978-3-662-12509-0

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1998

  • Softcover ISBN: 978-3-662-12511-3Published: 11 January 2013

  • eBook ISBN: 978-3-662-12509-0Published: 09 March 2013

  • Edition Number: 1

  • Number of Pages: XX, 412

  • Number of Illustrations: 42 b/w illustrations, 6 illustrations in colour

  • Additional Information: Jointly published with Landes Bioscience, Georgetown, USA

  • Topics: Cell Biology, Molecular Medicine, Human Genetics, Biochemistry, general, Oncology

  • Industry Sectors: Biotechnology, Pharma

Publish with us

Policies and ethics

Back to top

Search

Navigation