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Mitochondrial Structure, Function and Biogenesis

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Mitochondrial DNA Mutations in Aging, Disease and Cancer

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Abstract

Because of their symbiotic origin, mitochondria are often regarded as semiauto-nomous, bacteria-like structures suspended in the cytoplasm. Nevertheless, the structure and distribution of mitochondria are dependent on the activity and architecture of the whole cell, and the synthesis of mitochondrial components depends almost entirely on nuclear genes and cytoplasmic ribosomes. In turn, the eukaryotic cell invests mitochondria with metabolic activities on which survival, and sometimes suicide, depend.

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  1. Alfred S. Lewin
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  1. The Division of Experimental Therapeutics and Radiation Oncology, Johns Hopkins Oncology Center and Department of Environmental Health, Johns Hopkins School of Public Health, 600 N. Wolfe Street, Room 2-121, 21287, Baltimore, Maryland, USA

    Keshav K. Singh Ph.D.

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© 1998 Springer-Verlag Berlin Heidelberg

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Lewin, A.S. (1998). Mitochondrial Structure, Function and Biogenesis. In: Singh, K.K. (eds) Mitochondrial DNA Mutations in Aging, Disease and Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-12509-0_2

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  • DOI: https://doi.org/10.1007/978-3-662-12509-0_2

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