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The Mitochondrion as a Target for Cancer Chemotherapy

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Mitochondrial DNA Mutations in Aging, Disease and Cancer

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Abstract

Despite an intensive and prolonged effort to combat the disease, cancer remains a leading health threat worldwide today. Significantly, during 1996 there were more than 550,000 cancer deaths in the United States alone, with the vast majority of these attributed to cancers of epithelial origin. Traditional chemotherapies, aimed at DNA replication in actively dividing cells, have achieved only limited success in the treatment of carcinomas due largely to their lack of specificity for cells of turnorigenic origin. It is important, therefore, to search for novel cellular targets that are sufficiently different between normal cells and carcinoma cells so as to provide a basis for selective cytotoxicity. The mitochondrion may be one such target.

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Authors
  1. Josephine S. Modica-Napolitano
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Editors and Affiliations

  1. The Division of Experimental Therapeutics and Radiation Oncology, Johns Hopkins Oncology Center and Department of Environmental Health, Johns Hopkins School of Public Health, 600 N. Wolfe Street, Room 2-121, 21287, Baltimore, Maryland, USA

    Keshav K. Singh Ph.D.

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© 1998 Springer-Verlag Berlin Heidelberg

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Modica-Napolitano, J.S. (1998). The Mitochondrion as a Target for Cancer Chemotherapy. In: Singh, K.K. (eds) Mitochondrial DNA Mutations in Aging, Disease and Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-12509-0_16

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  • DOI: https://doi.org/10.1007/978-3-662-12509-0_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-12511-3

  • Online ISBN: 978-3-662-12509-0

  • eBook Packages: Springer Book Archive

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