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Pathophysiologie der Hirnischämie

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Zerebrale Ischämien

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Zusammenfassung

Das Gewicht des Gehirns beträgt nur 2% des Körpergewichtes, es erhält aber 15% des Herzminutenvolumens und verbraucht 20% des gesamten O2-Bedarfs des Körpers. Die Energieversorgung wird fast ausschließlich über den Glukosemetabolismus gedeckt. Dabei ist der Substratvorrat im Gehirn in Form von Glukose oder Glykogen begrenzt und reicht nur zur Deckung des Energiebedarfs für etwa 1 min aus. Infolgedessen besteht ein empfindliches Gleichgewicht zwischen O2-Versorgung und Nährstoffzufuhr über das Blut und dem Energiebedarf des Gehirns. Schon nach wenigen Sekunden der Ischämie treten (zunächst noch keine bleibenden) neurologischen Funktionsstörungen auf.

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Authors and Affiliations

  1. Department of Neurology, Streekziekenhuis, NL-7606 PP, Almelo, Niederlande

    Dr. med. Herman-J. Gelmers

  2. Neurologische Klinik, Universitätskliniken Mainz, Langenbeckstraße 1, D-6500, Mainz 1, Deutschland

    Dr. med. Günter Krämer

  3. Neurologische Klinik, Klinikum der Universität Heidelberg, Im Neuenheimer Feld 400, D-6900, Heidelberg 1, Deutschland

    Prof. Dr. med. Werner Hacke

  4. Neurologische Klinik, Med. Einrichtungen der Universität Düsseldorf, Moorenstraße 5, D-4000, Düsseldorf 1, Deutschland

    Prof. Dr. med. Michael Hennerici

Authors
  1. Dr. med. Herman-J. Gelmers
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  2. Dr. med. Günter Krämer
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  3. Prof. Dr. med. Werner Hacke
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  4. Prof. Dr. med. Michael Hennerici
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© 1989 Springer-Verlag Berlin Heidelberg

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Gelmers, HJ., Krämer, G., Hacke, W., Hennerici, M. (1989). Pathophysiologie der Hirnischämie. In: Zerebrale Ischämien. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10993-9_2

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  • DOI: https://doi.org/10.1007/978-3-662-10993-9_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-10994-6

  • Online ISBN: 978-3-662-10993-9

  • eBook Packages: Springer Book Archive

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