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Thrombotische Mikroangiopathie

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Hämostaseologie

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Zusammenfassung

Die thrombotische Mikroangiopathie (TMA) umschreibt ein akutes Krankheitsbild mit hoher Letalität, bei dem es aus ungeklärter Ursache zu Thrombosierung der Mikrozirkulation und Multiorganversagen kommt. Die TMA ist durch schwere Anämie und Thrombozytopenie, uncharakteristische fluktuierende neurologische Symptome, Niereninsuffizienz und Fieber charakterisiert. Das klinische Spektrum der TMA reicht von der thrombotisch-thrombozytopenischen Purpura (TTP, Morbus Moschcowitz) mit vorwiegend neurologischer Symptomatik bis zum hämolytisch-urämischen Syndrom (HUS), bei dem klinisch die Niereninsuffizienz im Vordergrund steht.

Es soll in diesem Beitrag nicht auf das “ klassische” HUS eingegangen werden, das bei Kleinkindern im Rahmen von Infektionen mit verozytotoxinbildender Escherichia coli Serotyp 0157:H7 oder shigatoxinproduzierender Shigella dysenteriae (Typ I) auftritt und sich durch gastrointestinale Prodromalsymptomatik, Fehlen neurologischer Symptome und guter Prognose von der TMA unterscheidet.

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Authors
  1. P. A. Kyrle
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Editors and Affiliations

  1. Kerckhoff-Klinik, Abteilung Hämostaseologie und Transfusionsmedizin, Max-Planck-Institut für physiologische und klinische Forschung, Sprudelhof 11, D-61231, Bad Nauheim, Deutschland

    Gert Müller-Berghaus  & Bernd Pötzsch  & 

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© 1999 Springer-Verlag Berlin Heidelberg

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Kyrle, P.A. (1999). Thrombotische Mikroangiopathie. In: Müller-Berghaus, G., Pötzsch, B. (eds) Hämostaseologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07673-6_63

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  • DOI: https://doi.org/10.1007/978-3-662-07673-6_63

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-07674-3

  • Online ISBN: 978-3-662-07673-6

  • eBook Packages: Springer Book Archive

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